NCRR - High end instrumentation (HEI)

NCRR - 高端仪器仪表 (HEI)

• 批准号: 6804175
• 负责人: J Richard Landis
• 金额: $ 61.27万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804175
• 关键词: biomedical equipment purchase; computer data analysis; computers; information systems; statistics /biometry

DESCRIPTION (provided by applicant): The Center for Clinical Epidemiology and Biostatistics (CCEB), together with the Abramson Cancer Center and Office of Human Research (OHR), at the University of Pennsylvania School of Medicine (UPENN SOM) is requesting a specialized research computing infrastructure in support of numerous, meritorious NIH-funded projects. This proposal requests a SUN SunFire 12K High-End Data Center Server, in support of large-scale database and statistical computing. The equipment will replace a seriously inadequate Oracle (r)database and statistical computing infrastructure, providing new computing performance, capacity and reliability. This proposal requests Oracle Clinical (r), specialized software that will permit a new capability for centralized management of clinical protocols, scientific data, regulatory compliance, and quality assurance. We propose these specific aims to ensure continued support of NIH projects: 1) replace an obsolete database environment, 2) replace an inadequate statistical computing environment, and 3) provide expanded computing performance, capacity, and new capability, so that current/future NIH projects can be centrally supported. In support, CCEB, the Abramson Cancer Center, and OHR present selected NIH projects potentially sustained by this equipment. CCEB projects (30 N1H projects with total costs, all years of $190M) range from statistical methodology R01s, to clinical research R01 and P01 projects, to cooperative agreements (U01,U10,U18) for Data Coordinating Centers (DCCs), and Centers for Education and Research Therapeutics (CERTs). The Abramson Cancer Center, an NCI- designated comprehensive Cancer Center, has 449 NIH funded projects ($130M total costs, all years.) This includes 19 P01s, 3 P50s, 15 cooperative U-type awards, and a vast array of clinical trials. OHR is responsible for the regulatory compliance of all clinical research (346 NIH projects with total costs, all years of $327M) conducted within the SOM. The Clinical Research Computing Unit (CRCU), a SOM Core Research Facility, provides the computing infrastructure required by large-scale clinical research and statistical methodology grants. These NIH projects require advanced database technologies, such as WWW-deployed remote data entry and management. These projects involve extensive statistical analysis, further increasing computing infrastructure needs. The CRCU provides and maintains equipment configured for the Oracle (r) Database Management System, SAS (r), S-PLUS (r), and STATA(r); however, expanding NIH research has exceeded the performance, capacity, dependability, and capability limits of the servers installed in 1997. Each newly funded NIH project further stresses the computing infrastructure, without adding new capabilities for centrally managing trials. This specialized computing equipment request meets the NCRR goals of providing shared resources across multiple grants that are cost-prohibitive and difficult to justify for individual projects.

描述（由申请人提供）：宾夕法尼亚大学医学院（UPENN SOM）的临床流行病学与生物统计学中心（CCEB）以及艾布拉姆森癌症中心和人类研究办公室（OHR）（OHR）正在要求一项专门研究基础设施的专业研究，以支持众多，有许多的NIH-NIH-NIH基金项目。该提案请求Sun Sunfire 12K高端数据中心服务器，以支持大规模数据库和统计计算。该设备将取代严重不足的Oracle（R）数据库和统计计算基础架构，从而提供新的计算性能，容量和可靠性。该建议要求Oracle临床（R），专门的软件，该软件将允许对临床方案，科学数据，法规合规性和质量保证的集中管理的新能力。我们提出了这些具体目标，以确保对NIH项目的持续支持：1）替换过时的数据库环境，2）替换不充分的统计计算环境，3）提供扩展的计算性能，容量和新功能，以便可以中心支持当前/未来的NIH项目。为了支持，CCEB，Abramson Cancer Center和OHR现在可能由该设备维持的NIH项目。 CCEB项目（30个N1H项目总成本，所有年度为1.9亿美元）范围从统计方法R01s到临床研究R01和P01项目，再到合作协议（U01，U10，U18），用于数据协调中心（DCCS），以及教育和研究中心（DCCS），以及教育和研究中心（CERTS）。艾布拉姆森癌症中心（Abramson Cancer Center）是一个指定的综合癌症中心，拥有449个NIH资助的项目（全年总成本，总成本为1.3亿美元）。这包括19个P01，3个P50，15个合作社U型奖项和大量临床试验。 OHR负责所有临床研究（346个NIH项目，总成本，全年3.27亿美元）的监管合规性。 SOM核心研究机构临床研究计算单元（CRCU）提供了大规模临床研究和统计方法学赠款所需的计算基础设施。这些NIH项目需要高级数据库技术，例如www开发的远程数据输入和管理。这些项目涉及广泛的统计分析，进一步增加了计算基础架构需求。 CRCU提供并维护为Oracle（R）数据库管理系统，SAS（R），S-Plus（R）和Stata（R）配置的设备；但是，扩大的NIH研究超出了1997年安装的服务器的性能，容量，可靠性和能力限制。每个新资助的NIH项目都进一步强调了计算基础设施，而无需添加新的功能以用于中央管理试验。这个专业的计算设备请求符合NCRR的目标，即在成本过高且难以证明个人项目合理的多种赠款中提供共享资源。