Microneedle-based Transdermal Sensing of Electrolytes: Towards A Metabolic Panel-

基于微针的电解质透皮传感：迈向代谢组 -

• 批准号: 8779957
• 负责人: JOSEPH WANG
• 金额: $ 30万
• 依托单位: BIOLINQ INCORPORATED
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8779957
• 关键词: 3-Dimensional; 3D Print; Address; Adoption; Archives; Bicarbonate Ion; Bicarbonate Ions; Bicarbonates; Binding; Biological Markers; Biosensor; Blood; Chemicals; Chemistry; Chloride Ion; Chronic; Chronic Disease; Clinical; Data; Deposition; Detection; Development; Devices; Diabetes Mellitus; Eating; Electrochemistry; Electrodes; Electrolyte Balance; Electrolytes; Electrons; Elements; Evaluation; Exhibits; Feedback; Film; Fluid Balance; General Population; Health Personnel; Health care facility; Healthcare; Hepatic; Hospitals; Human; Hypertension; Immobilization; Individual; Ionophores; Ions; Kidney; Kidney Diseases; Laboratories; Life Style; Liquid substance; Measurement; Measures; Medical; Membrane; Metabolic; Methods; Metric; Microelectrodes; Monitor; Nursing Staff; Outcome; Outcomes Research; Pain; Pain-Free; Patients; Performance; Pharmaceutical Preparations; Physical activity; Physiological; Polymers; Potassium Chloride; Price; Primary Health Care; Printing; Process; Renal function; Research; Research Infrastructure; Research Project Grants; Sampling; Serum; Skin; Sleep; Sodium; Staging; Surface; System; Techniques; Time; Training; Transducers; Venipunctures; Visit; Wireless Technology; base; cost; design; effective therapy; follow-up; improved; innovation; member; minimally invasive; novel; potassium ion; public health relevance; response; screening; sensor; sodium ion; trend

DESCRIPTION (provided by applicant): The metabolic panel has emerged as the standard line of inquiry for initial screening as well as follow-up assessment in the healthcare domain. Administered via blood draw in the clinical setting, the metabolic panel consists of assessing 14 unique blood-borne analytes indicative of renal and hepatic function, electrolyte and fluid balance, diabetes mellitus, kidney disease, and hypertension. Despite the clinical utility of the metabolic panel, the process of drawing blood is inconvenient, painful, and can only provide a snapshot of the patient's metabolic function at a particular moment in time, thereby limiting its utility for monitoring chronic conditions. However, in order to be effective, treatment of chronic conditions entails a concerted and proactive effort to manage healthcare throughout the daily routine, which would be substantially enhanced if circulating metabolite and electrolyte levels were able to be quantified on a continuous (rather than intermittent) basis. This project aims to address the above limitations of a conventional metabolic panel via the development of a "Metabolic-Panel-on-A-Chip". The proposed device leverages our team's latest innovations in electrochemistry, 3D-printing, conducting polymers, and surface functionalization to tender the real-time profile of blood-based electrolytes in a minimally-invasive, pain-free fashion, thereby leading to substantially improved clinical outcomes among the general population as well as those afflicted with chronic disease. Expected outcomes from this research project include: (1) the development of minimally-invasive microneedle arrays containing electrochemical transducers that exhibit chemical selectivity towards sodium, potassium, chloride, and bicarbonate ions and (2) the ability to fabricate the said microneedle arrays employing high-throughput, low- cost 3D-printing methods. This agglomerates innovative techniques for the functionalization of the microneedle contingents and relies on the development of ion-selective membranes in connection with novel methods of electrochemical transduction. The salient features of this transdermal biosensor platform include high sensitivity, stability, selectivity, simplicity, versatility, and robustness at a price that is amenable to widespread healthcare adoption. The proposed microneedle array biosensor will thus fill a long-standing void by enabling the healthcare provider to record, archive, and assess the metabolic response of the patient to the administration of various medical treatments, medications, and therapies, resulting in improved management of chronic disease.

描述（由申请人提供）：代谢小组已成为医疗保健领域初步筛查和随访评估的标准查询线。在临床环境中通过抽血进行管理，代谢组包括评估14种独特的血液传播分析物，这些分析物指示肾和肝功能、电解质和液体平衡、糖尿病、肾脏疾病和高血压。尽管代谢小组具有临床实用性，但是抽血的过程是不方便的、痛苦的，并且只能及时提供患者在特定时刻的代谢功能的快照，从而限制了其用于监测慢性病症的实用性。然而，为了有效，慢性疾病的治疗需要协调一致和积极主动的努力来管理整个日常生活中的医疗保健，如果能够连续（而不是间歇）量化循环代谢物和电解质水平，这将大大提高。本项目旨在通过开发“芯片上代谢检测板”来解决传统代谢检测板的上述局限性。该设备利用我们团队在电化学，3D打印，导电聚合物和表面功能化方面的最新创新，以微创，无痛的方式提供血液电解质的实时分布，从而大大改善普通人群以及慢性疾病患者的临床结果。该研究项目的预期成果包括：（1）开发含有电化学换能器的微创微针阵列，所述电化学换能器对钠、钾、氯和碳酸氢根离子表现出化学选择性，以及（2）采用高通量、低成本3D打印方法制造所述微针阵列的能力。这凝聚了用于微针特遣队功能化的创新技术，并依赖于与电化学转导的新方法相关的离子选择性膜的开发。这种透皮生物传感器平台的显著特征包括高灵敏度、稳定性、选择性、简单性、多功能性和鲁棒性，其价格适合于广泛的医疗保健采用。因此，所提出的微针阵列生物传感器将通过使医疗保健提供者能够记录、存档和评估患者对各种医学治疗、药物和疗法的施用的代谢反应来填补长期存在的空白，从而改善慢性疾病的管理。