Administrative Coordinating Core - URBAN ARCH Consortium

行政协调核心 - URBAN ARCH Consortium

• 批准号: 8531067
• 负责人: JEFFREY H. SAMET
• 金额: $ 32.04万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531067
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Affect; Alcohol consumption; Alcohols; Attention; Awareness; Biometry; Boston; Buprenorphine; Clinical; Cohort Studies; Collaborations; Communication; Communities; Complex; Data; Development; Disease; Ensure; Epidemic; Epidemiology; Goals; HIV; HIV Infections; Healthcare; Heavy Drinking; Individual; Internal Medicine; International; Intervention Studies; Knowledge; Leadership; Medicine; National Institute on Alcohol Abuse and Alcoholism; Opiate Addiction; Outcome; Pattern; Population; Positioning Attribute; Principal Investigator; Productivity; Psychiatry; Public Health; Research; Research Infrastructure; Research Personnel; Resources; Russia; Sampling; Scientist; Site; Transcend; Uganda; United States; Woman; Work; Zinc; addiction; advanced disease; alcohol consequences; alcohol research; bone health; cohort; data management; data sharing; drinking; effective therapy; high risk drinking; improved; inflammatory marker; innovation; insight; knowledge base; men; multidisciplinary; repository; success; transmission process; treatment strategy

DESCRIPTION (provided by applicant): In the fourth decade of the HIV epidemic, many questions remain about how alcohol use affects HIV clinical manifestations and how treatments beyond ART might mitigate alcohol-related harms. Such questions about the complex relationship between HIV and alcohol need to be addressed in order to accelerate the development of more effective treatments. The Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium will carry out cohort and intervention studies under the leadership of the Administrative Coordinating Core (Admin Core) to address gaps in our understanding about HIV and alcohol. The central goal of the URBAN ARCH Consortium is to examine the consequences of alcohol on HIV disease and to mitigate its harmful effects. To realize this goal, the URBAN ARCH Consortium will incorporate the expertise of researchers in epidemiology, internal medicine, addiction medicine, HIV/AIDS, psychiatry and biostatistics, under the leadership of a Consortium PI who is a leader in the field of HIV and clinical addiction medicine. The Consortium studies will build on three existing HIV- infected cohorts from Boston, Uganda, and Russia with distinctive strengths and well-characterized alcohol consumption patterns. The two international cohorts allow study of clinical issues that would not be possible in the United States, yet have important implications for US HIV-infected populations. The objective of the Admin Core is to ensure that the scientific and programmatic goals of the URBAN ARCH Consortium are achieved with high quality and timeliness. Accordingly, the Admin Core will accomplish the following Specific Aims: Promote a collaborative, integrated approach to research goals; Facilitate constructive communication and creative collaboration between all Consortium components; Coordinate and prioritize access to resources including the URBAN ARCH data and sample repository; Assess components' progress and quality to maximize the scientific impact of the Consortium; Encourage the sharing of data to investigators within and outside the Consortium. The accomplishment of the Admin Core's aims will maximize the overall productivity of the URBAN ARCH Consortium and realize the potential of the outstanding multi-institutional, inter-disciplinary, and international collaborations. In working with all of the Consortium components, the Admin Core will ensure adherence to preplanned aims and support new evolving lines of scientific inquiry consistent with the Consortium's goal.

描述（由申请人提供）：在艾滋病毒流行的第四个十年，许多问题仍然是关于酒精使用如何影响艾滋病毒的临床表现，以及如何超越ART治疗可能减轻酒精相关的伤害。艾滋病毒与酒精之间的复杂关系需要解决，以加快开发更有效的治疗方法。乌干达俄罗斯波士顿酒精网络艾滋病毒/艾滋病酒精研究合作（URBAN联盟）联盟将在行政协调核心（管理核心）的领导下开展队列和干预研究，以解决我们对艾滋病毒和酒精的理解方面的差距。城市酒精联盟的中心目标是研究酒精对艾滋病毒疾病的影响，并减轻其有害影响。为了实现这一目标，URBAN成瘾医学联盟将在艾滋病毒和临床成瘾医学领域的领导者PI联盟的领导下，整合流行病学、内科学、成瘾医学、艾滋病毒/艾滋病、精神病学和生物统计学研究人员的专业知识。该联盟的研究将建立在来自波士顿、乌干达和俄罗斯的三个现有艾滋病毒感染群体的基础上，这些群体具有独特的优势和良好的饮酒模式。这两个国际队列允许研究在美国不可能的临床问题，但对美国艾滋病毒感染人群具有重要意义。管理核心的目标是确保高质量和及时地实现城市规划联盟的科学和方案目标。因此，管理核心将实现以下具体目标：促进研究目标的合作，综合方法;促进联盟所有组成部分之间的建设性沟通和创造性合作;协调和优先考虑对资源的访问，包括URBAN数据和样本库;评估组成部分的进度和质量，以最大限度地发挥联盟的科学影响;鼓励与联盟内外的研究者共享数据。Admin Core目标的实现将最大限度地提高URBAN联盟的整体生产力，并实现优秀的多机构，跨学科和国际合作的潜力。在与联合会所有组成部分的合作中，管理核心将确保遵守预先计划的目标，并支持与联合会目标一致的新的不断发展的科学探索路线。