Rapid Robust Pediatric MRI

快速稳健的儿科 MRI

• 批准号: 8696566
• 负责人: Shreyas S Vasanawala
• 金额: $ 36.68万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8696566
• 关键词: Abdomen; Acceleration; Address; Adult; Algorithms; Anatomic structures; Anesthesia procedures; Appendicitis; Body Image; Breathing; Calibration; Child; Child health care; Childhood; Clinic; Clinical; Clinical Research; Data; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Elements; Financial compensation; Freezing; Frequencies; Healthcare; Image; Incidence; Ionizing radiation; Lead; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Methods; Modality; Morphologic artifacts; Motion; Motivation; Patients; Population; Protocols documentation; Radiation; Resolution; Respiration; Risk; Role; Scanning; Sedation procedure; Sensitivity and Specificity; Signal Transduction; Slice; Solutions; Speed; Structure; System; Techniques; Technology; Three-Dimensional Imaging; Time; Validation; Weight; Work; X-Ray Computed Tomography; base; cancer risk; clinical practice; community setting; cost effective; data space; design; design and construction; experience; heart motion; image reconstruction; imaging modality; improved; innovation; novel; novel strategies; parallel computer; public health relevance; reconstruction; research and development; respiratory; skills; soft tissue; spatiotemporal; success; validation studies

DESCRIPTION (provided by applicant): Motivation: This is a competing renewal of our successful project Rapid Robust Pediatric MRI, R01 EB009690. MRI offers superb soft tissue contrast and high resolution for children, without the ionizing radiation and cancer risk of CT. However, its use has been limited as children often cannot voluntarily suspend respiration or tolerate long exams. MRI often requires anesthesia with attendant risk; hence, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. The previous project addressed these concerns by creating a dedicated pediatric imaging system. Highly parallel, high SNR 3T receive arrays were designed and constructed specifically for pediatric body imaging. The high SNR was used to accelerate scans reconstructed with a combination of parallel imaging, new motion correction algorithms, and compressed sensing (CS). Parallel computing reconstruction algorithms produced 3D volumes in 1 minute. The resulting system is being used extensively in clinical practice, significantly reducing anesthesia, and has markedly increased our abdominal MRI utilization. Key technologies are now being commercialized with GE Healthcare, including the pediatric receive array, CS, and coil compression. Despite significant progress, with markedly reduced scan times, anesthesia has not been eliminated. Patient motion remains the main limitation. Therefore the major emphasis here is addressing motion through robust imaging, motion correction, and dynamic MRI. This will (1) extend the benefits of MRI to younger, less cooperative patients, (2) allow the correction and depiction of respiratory motion, and (3) provide the temporal resolution that captures the faster contrast dynamics in children for free-breathing 3D dynamic studies. Approach: The project has three interrelated development aims, validated by clinical studies. Aim 1 is to enable robust acquisition and reconstruction in the presence of motion in 3D studies. This uses robust parallel imaging calibration and reconstruction, outlier insensitive optimization and a new approach for measuring localized non-rigid motion throughout the body using array coil elements. A second aim is to develop ultrafast multi band 2D approaches for faster imaging of uncooperative patients. This freezes motion in each set of slices, simplifying motion correction over the volume. The impact of these developments in the clinic will then be assessed in the setting of appendicitis, a representative common and challenging pediatric abdominal imaging application. Then we will exploit temporal correlations and dynamics in time-resolved 3D contrast studies and further speed 2D scans, and again assess the impact in children with suspected appendicitis. Significance: This work will lead to fast, robust, broadly-applicable pediatric body MRI protocols with less anesthesia, making MRI safer, cheaper, and more available to children, transforming it into a workhorse modality and decreasing CT radiation burden. The techniques will facilitate wide application in the community setting and permit new MRI applications, for both pediatric and adult disease.

描述（由申请人提供）：动机：这是我们成功的项目Rapid Robust Pediatric MRI（R01 EB009690）的竞争性更新。MRI为儿童提供了极好的软组织对比度和高分辨率，没有CT的电离辐射和癌症风险。然而，它的使用受到限制，因为儿童往往不能自愿暂停呼吸或忍受长时间的检查。MRI通常需要麻醉，伴随着风险;因此，儿童通常完全缺乏横断面成像的好处或暴露于电离辐射。先前的项目通过创建专用的儿科成像系统来解决这些问题。高度平行、高SNR的3T接收阵列是专门为儿科身体成像而设计和构造的。高SNR用于加速并行成像、新运动校正算法和压缩感知（CS）组合重建的扫描。并行计算重建算法在1分钟内产生3D体积。由此产生的系统正在临床实践中广泛使用，显着减少麻醉， 并显著提高了我们腹部核磁共振的利用率关键技术目前正在与GE Healthcare进行商业化，包括儿科接收阵列、CS和线圈压缩。尽管取得了重大进展，扫描时间明显减少，但麻醉尚未消除。患者运动仍然是主要限制。因此，这里的主要重点是通过强大的成像，运动校正和动态MRI来解决运动问题。这将（1）将MRI的受益扩展到年轻、不太合作的患者，（2）允许纠正 和呼吸运动的描绘，以及（3）提供时间分辨率，其捕获儿童中的更快对比动态，用于自由呼吸3D动态研究。方法：该项目有三个相互关联的发展目标，并通过临床研究进行了验证。目标1是在3D研究中存在运动的情况下实现稳健的采集和重建。这使用了强大的并行成像校准和重建，离群值不敏感的优化和一种新的方法，用于测量局部非刚性运动在整个身体使用阵列线圈元件。第二个目标是开发超快多波段2D方法，用于不合作患者的更快成像。这冻结了每组切片中的运动，简化了体积上的运动校正。这些发展对临床的影响将在阑尾炎的背景下进行评估，阑尾炎是一种具有代表性的常见和具有挑战性的儿科腹部成像应用。然后，我们将在时间分辨的3D对比研究和进一步的2D扫描速度中利用时间相关性和动力学，并再次评估对疑似阑尾炎儿童的影响。重要性：这项工作将导致快速，强大，广泛适用的儿科身体MRI协议，减少麻醉，使MRI更安全，更便宜，更适合儿童，将其转变为主力模式并减少CT辐射负担。该技术将促进在社区环境中的广泛应用，并允许新的MRI应用于儿科和成人疾病。