Rapid Robust Pediatric MRI

快速稳健的儿科 MRI

• 批准号: 8696566
• 负责人: Shreyas S Vasanawala
• 金额: $ 36.68万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8696566
• 关键词: Abdomen; Acceleration; Address; Adult; Algorithms; Anatomic structures; Anesthesia procedures; Appendicitis; Body Image; Breathing; Calibration; Child; Child health care; Childhood; Clinic; Clinical; Clinical Research; Data; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Elements; Financial compensation; Freezing; Frequencies; Healthcare; Image; Incidence; Ionizing radiation; Lead; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Methods; Modality; Morphologic artifacts; Motion; Motivation; Patients; Population; Protocols documentation; Radiation; Resolution; Respiration; Risk; Role; Scanning; Sedation procedure; Sensitivity and Specificity; Signal Transduction; Slice; Solutions; Speed; Structure; System; Techniques; Technology; Three-Dimensional Imaging; Time; Validation; Weight; Work; X-Ray Computed Tomography; base; cancer risk; clinical practice; community setting; cost effective; data space; design; design and construction; experience; heart motion; image reconstruction; imaging modality; improved; innovation; novel; novel strategies; parallel computer; public health relevance; reconstruction; research and development; respiratory; skills; soft tissue; spatiotemporal; success; validation studies

DESCRIPTION (provided by applicant): Motivation: This is a competing renewal of our successful project Rapid Robust Pediatric MRI, R01 EB009690. MRI offers superb soft tissue contrast and high resolution for children, without the ionizing radiation and cancer risk of CT. However, its use has been limited as children often cannot voluntarily suspend respiration or tolerate long exams. MRI often requires anesthesia with attendant risk; hence, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. The previous project addressed these concerns by creating a dedicated pediatric imaging system. Highly parallel, high SNR 3T receive arrays were designed and constructed specifically for pediatric body imaging. The high SNR was used to accelerate scans reconstructed with a combination of parallel imaging, new motion correction algorithms, and compressed sensing (CS). Parallel computing reconstruction algorithms produced 3D volumes in 1 minute. The resulting system is being used extensively in clinical practice, significantly reducing anesthesia, and has markedly increased our abdominal MRI utilization. Key technologies are now being commercialized with GE Healthcare, including the pediatric receive array, CS, and coil compression. Despite significant progress, with markedly reduced scan times, anesthesia has not been eliminated. Patient motion remains the main limitation. Therefore the major emphasis here is addressing motion through robust imaging, motion correction, and dynamic MRI. This will (1) extend the benefits of MRI to younger, less cooperative patients, (2) allow the correction and depiction of respiratory motion, and (3) provide the temporal resolution that captures the faster contrast dynamics in children for free-breathing 3D dynamic studies. Approach: The project has three interrelated development aims, validated by clinical studies. Aim 1 is to enable robust acquisition and reconstruction in the presence of motion in 3D studies. This uses robust parallel imaging calibration and reconstruction, outlier insensitive optimization and a new approach for measuring localized non-rigid motion throughout the body using array coil elements. A second aim is to develop ultrafast multi band 2D approaches for faster imaging of uncooperative patients. This freezes motion in each set of slices, simplifying motion correction over the volume. The impact of these developments in the clinic will then be assessed in the setting of appendicitis, a representative common and challenging pediatric abdominal imaging application. Then we will exploit temporal correlations and dynamics in time-resolved 3D contrast studies and further speed 2D scans, and again assess the impact in children with suspected appendicitis. Significance: This work will lead to fast, robust, broadly-applicable pediatric body MRI protocols with less anesthesia, making MRI safer, cheaper, and more available to children, transforming it into a workhorse modality and decreasing CT radiation burden. The techniques will facilitate wide application in the community setting and permit new MRI applications, for both pediatric and adult disease.

描述(由申请人提供)：动机：这是我们成功的项目快速稳健的儿科磁共振成像，R01 EB009690的竞争续订。MRI为儿童提供了极佳的软组织对比度和高分辨率，没有CT的电离辐射和癌症风险。然而，由于儿童通常不能自愿暂停呼吸或忍受漫长的考试，它的使用受到了限制。核磁共振通常需要麻醉，并伴随着风险；因此，儿童通常完全缺乏横断面成像的好处，或者暴露在电离辐射中。先前的项目通过创建专门的儿科成像系统解决了这些问题。高度并行、高信噪比的3T接收阵列是专门为儿童身体成像而设计和建造的。高信噪比被用来加速并行成像、新的运动校正算法和压缩传感(CS)的组合重建的扫描。并行计算重建算法在1分钟内产生了3D体积。由此产生的系统在临床实践中得到了广泛的应用，大大减少了麻醉， 并显著提高了我们腹部MRI的利用率。GE Healthcare目前正在将关键技术商业化，包括儿科接收阵列、CS和线圈压缩。尽管取得了重大进展，扫描时间明显减少，但麻醉并未被消除。患者的运动仍然是主要的限制。因此，这里的主要重点是通过稳健的成像、运动校正和动态MRI来处理运动。这将(1)将MRI的好处扩展到更年轻、更不合作的患者，(2)允许矫正 和呼吸运动的描述，以及(3)提供时间分辨率，为自由呼吸3D动态研究捕捉儿童更快的对比度动力学。方法：该项目有三个相互关联的发展目标，并得到临床研究的验证。目标1是在3D研究中实现在存在运动的情况下的稳健获取和重建。这采用了稳健的并行成像校准和重建、离群点不敏感优化以及使用阵列线圈元件测量全身局部非刚性运动的新方法。第二个目标是开发超快多波段2D方法，以更快地对不合作的患者进行成像。这冻结了每组切片中的运动，简化了体积上的运动校正。这些发展在临床上的影响将在阑尾炎的背景下进行评估，阑尾炎是一种具有代表性的常见且具有挑战性的儿科腹部成像应用。然后，我们将在时间分辨的3D对比研究中利用时间相关性和动力学，进一步加快2D扫描，并再次评估对疑似阑尾炎儿童的影响。意义：这项工作将导致快速、可靠、广泛适用的儿科体部MRI方案，减少麻醉，使MRI更安全、更便宜，更容易为儿童提供，将其转变为一种主要的方式，并减少CT辐射负担。这些技术将促进在社区环境中的广泛应用，并允许新的磁共振应用于儿科和成人疾病。