Development and Validation of Radiation-Free Pediatric Renal Function Quantification
无辐射儿童肾功能定量的开发和验证
基本信息
- 批准号:9501621
- 负责人:
- 金额:$ 68.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-04-05 至 2022-01-31
- 项目状态:已结题
- 来源:
- 关键词:4D ImagingAddressAdoptedAdultAffectAgeAgingAnatomyAntibioticsAreaBiological MarkersBloodBlood flowBreathingCardiac OutputChildChildhoodChronic Kidney FailureClinicalClinical ManagementClinical ResearchConeContrast MediaDataDevelopmentDiagnosisDiseaseDrug KineticsEnd stage renal failureEvaluationEvolutionFailureFinancial compensationFunctional Magnetic Resonance ImagingFurosemideGadoliniumGlomerular Filtration RateGoldGrowthHydronephrosisHypertensionImageImage AnalysisInjectionsIonizing radiationKidneyKidney DiseasesKineticsMachine LearningMagnetic Resonance ImagingMainstreamingMalignant Childhood NeoplasmManualsMeasurementMeasuresMethodsMotionMotivationNeurocognitive DeficitObstructionPatientsPerformancePerfusionPharmaceutical PreparationsPhasePlasmaProtocols documentationRadiationRegimenRenal Blood FlowRenal Plasma FlowRenal functionReproducibilityResolutionSignal TransductionTechniquesTestingTimeToxic effectUrinary tractUrineValidationVenousWorkantimicrobial drugbasecardiovascular risk factorchemotherapeutic agentchemotherapycommunity settingcomputerized data processingcontrast enhanceddata acquisitionexperienceimage processingimaging Segmentationimaging modalityimprovedkidney cortexkidney imagingloss of functionnephrotoxicitynoveloncologypressurereconstructionrecruitspatiotemporalstemurinaryurinary tract obstructionurologic
项目摘要
Project Abstract
Motivation: Chronic kidney disease (CKD) affects more than 500 million people. Children commonly develop
CKD from urinary obstructive diseases and nephrotoxic therapies, and then suffer severe growth failure, hyper-
tension, cardiovascular risks, and neurocognitive deficits, and eventually end-stage kidney disease. Accurate
renal function quantification will improve clinical management of hydronephrosis (1 in 100 babies) and dos-
ing/selection of chemotherapeutic regimens in oncology patients.
Glomerular filtration rate (GFR), the biomarker of renal function, is derived from blood or urine tests. These
tests only provide global GFR and are limited in accuracy, especially in children, and even more so in children
with cancer. MRI offers superb anatomic delineation without ionizing radiation, and is thus ideal for pediatric
kidney imaging. However, MRI has not been widely adopted for pediatric renal function evaluation due to lack
of reliability and cumbersome workflow. These hurdles stem from the fact that the critical components required
for global and regional GFR calculation, including high spatiotemporal resolution, plasma flow and arterial input
function, are difficult to obtain, and that accurate image segmentation of kidneys (cortex and medulla) is labor
intensive. Additionally, although the same contrast agent injection can be used for obstruction evaluation, certain
areas of the kidney suffer from significant signal loss using standard MRI acquisition techniques due to high
contrast agent concentrations. This project addresses these major challenges for automated comprehensive
renal function evaluation in children.
Approach: The project has three development aims, which are validated by clinical studies. Aim 1 will enable
novel free-breathing time-resolved 3D dynamic contrast enhanced MRI that simultaneously provides accurate
GFR calculation and renal plasma flow. This is achieved by incorporating self-navigated motion compensation,
fast acquisition with parallel imaging and compressed sensing, and phase-contrast flow imaging. The second
aim is to develop multiple new image analysis methods to extract GFR and renal plasma flow (RPF) that lever-
age novel flow data of Aim 1, as well as automated new machine-learning image processing techniques for
the segmentation of kidneys and ultimately global and regional GFR calculation. In Aim 3, we will develop and
integrate ultrashort-echo-time techniques to address the MRI signal loss due to T2* effects from high contrast
concentration for patients with obstruction, and further incorporate motion compensation and accelerated imag-
ing methods to enable time-resolved high-resolution dynamic MRI for contrast washout kinetics analysis in the
same MR exam. Aim 4 will determine the performance of these methods in a clinical setting.
Significance: This work will lead to robust, automated comprehensive pediatric renal MRI for safer and more
accurate renal function evaluation in children. The techniques will facilitate widespread application in the com-
munity setting and permit robust evaluation of renal function, for both children and adults.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(3)
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Shreyas S Vasanawala其他文献
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{{ truncateString('Shreyas S Vasanawala', 18)}}的其他基金
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