Neonatal Esophagus and Airway Interaction in Health and Disease

新生儿食道和气道在健康和疾病中的相互作用

• 批准号: 8742109
• 负责人: Sudarshan R Jadcherla
• 金额: $ 38.39万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8742109
• 关键词: Accounting; Acids; Address; Admission activity; Age-Months; Biological Markers; Bolus Infusion; Caring; Characteristics; Chronic; Clinical; Complex; Data; Deglutition; Deglutition Disorders; Diagnostic; Dietetics; Disease; Economic Burden; Economics; Effectiveness; Electrocardiogram; Esophageal; Esophagus; Fluoroscopy; Functional disorder; Future; Gagging; Gastroesophageal reflux disease; Goals; Growth; Health; Healthcare; Hospitalization; Impairment; Infant; Inferior esophageal sphincter structure; Innovative Therapy; Instruction; Intake; Knowledge; Larynx; Length of Stay; Manometry; Medical; Modification; Morbidity - disease rate; Motor; Multicenter Trials; Neonatal; Normalcy; Operative Surgical Procedures; Oral; Outcome; Parents; Penetration; Peristalsis; Pharyngeal structure; Physiology; Plethysmography; Population; Premature Infant; Program Research Project Grants; Pulse Oximetry; Quality of life; Randomized Controlled Trials; Reflex action; Reflux; Resolution; Safety; Sensory; Subgroup; Term Birth; Testing; Therapeutic; Therapeutic Intervention; Time; Upper Esophageal Sphincter; Viscosity; base; care burden; economic outcome; electric impedance; feeding; improved; indexing; innovation; migration; novel; novel diagnostics; respiratory; restoration; standard of care; success

In the infant population, the complex issues of dysphagia and swallowing remain to be a conundrum when it comes to the care management of this population. The lack of a pathophysiology guided diagnostic and safe feeding management strategies continue to be critical barriers to progress in this field. This proposal will focus on the dynamic changes in the integrative physiology of the neonatal pharynx, upper esophageal sphincter (UES), lower esophageal sphincter (LES) and esophagus during swallowing and GERD. The overall goal of this project is to examine new management approaches of dysphagia in the infant population. This project will address two aims. Aim 1: Effectiveness of two feeding strategies on clinical-, safety- and economic- outcomes in dysphagic infants with anterograde aspiration. The goal of this Aim is to develop novel feeding strategies, to improve clinical outcomes and to clarify aerodigestive protective mechanisms in oral-fed infants (under 6 months of age) with abnormalities proven by diagnostic video fluroscopy swallow study (VFSS). Aim 2: Mechanisms and Impact of feeding strategies on pharyngeal and esophageal sensitivity of aerodigestive reflexes in dysphagia with or without GERD. The goal of this Aim is to differentiate GERD and its consequences by examining the sensory-motor characteristics of the swallow, various reflexes and aero-digestive coordination using manometric studies.

在婴儿群体中，吞咽困难和吞咽等复杂问题仍然是一个难题，当它 涉及到这一人群的护理管理。缺乏病理生理学指导的诊断和安全 喂养管理战略仍然是这一领域取得进展的关键障碍。这项提议将 关注新生儿咽、上食道综合生理的动态变化 吞咽和GERD时的括约肌(UES)、下食道括约肌(LES)和食道。这个 这个项目的总体目标是检查婴儿人口吞咽困难的新管理方法。 该项目将解决两个目标。 目的1：两种喂养策略对吞咽困难患者的临床、安全和经济结果的有效性 顺行吸入的婴儿。 这一目标的目的是开发新的喂养策略，改善临床结果并澄清 经证实有异常的口服喂养婴儿(6个月以下)的空气消化保护机制 通过诊断视频荧光镜吞咽研究(VFSS)。 目的2：不同喂养策略对婴幼儿咽部和食道敏感性的影响及机制 伴或不伴GERD的吞咽困难患者的空气消化反射。 这一目标的目的是通过检查感觉运动来区分GERD及其后果 通过测压研究吞咽、各种反射和空气-消化协调的特点。