Loma Linda University Center for Health Disparities Research

描述（由申请人提供）：洛马林达大学健康差异研究中心（LLU CHDR）是由NCMHD的EXPORT奖建立的，旨在为LLU和南加州内陆帝国（IE）地区的健康差异研究开发新的基础设施。这个竞争性更新应用程序的总体目标是支持一个已经在IE中解决健康差异的成功企业。这一申请的四个目标是：目标1：加强法学大学的研究和行政基础设施，以便在健康差异方面开展有竞争力和可持续的研究、培训、教育和推广。这一目标将确保拥有有效的管理基础设施来支持该中心。目标2是建立一个成功的健康差异研究企业，导致转化发现，以减少乳腺癌，前列腺癌和2型糖尿病差异的负担。研究墨西哥裔美国人2型糖尿病中基因-环境相互作用的创新方法，研究患有前列腺癌的非洲裔美国男性的免疫血清蛋白质组学分析，以及非洲裔美国女性的三阴性乳腺癌化疗耐药性，将引导该中心解决这些致命疾病，这些疾病不成比例地影响着服务不足的社区。目标3是维持来自代表性不足和医疗服务不足人群的健康差异研究人员的全面和强大的渠道。该中心已经确定了数百名来自健康差异人群的学生，他们一直在参与这个成功的项目。目标4是与已建立的社区卫生组织和法律合作伙伴关系网络合作，解决健康差距问题，并促进将乳腺癌、前列腺癌和2型糖尿病方面的进展转化为服务不足的社区。实现这一目标将导致一支训练有素并获得法学大学认证的“推广人员”队伍参与预防教育计划，以减轻加州这一服务不足地区健康差异疾病的负担。这些目标的实现将使LLU CHDR/CHDMM成为卓越研究，培训和成功合作伙伴关系的既定资源。

DESCRIPTION (provided by applicant): The Loma Linda University Center for Health Disparities Research (LLU CHDR) was established by an EXPORT award from the NCMHD to develop new infrastructure for research in health disparities at LLU and the Inland Empire (IE) region of Southern California. The overall goal of this competitive renewal application is to support a successful enterprise that is already addressing health disparities in the IE. The four objectives of this application are: Objective 1: To enhance the research and administrative infrastructure of LLU to conduct competitive and sustainable research, training, education and outreach in health disparities. This objective will ensure having an efficient administrative infrastructure to support the center. Objective 2 is to build a successful enterprise in health disparities research leading to translational discoveries to reduce the burden of breast cancer, prostate cancer, and type 2 diabetes disparities. Innovative approaches to study gene-environmental interactions in type 2 diabetes in Mexican Americans, immunoseroproteomics profiling in African American men with prostate cancer, and triple negative breast cancer chemoreslstance in African American women, will lead the center to address these killer diseases that are disproportionately impacting underserved communities. Objective 3 is to sustain a comprehensive and robust pipeline of health disparities researchers from underrepresented and medically underserved populations. The center has identified a pool of hundreds of students from health disparities populations that have been participating in this successful program. Objective 4 is to engage with an established network of CBOs and LLU partnerships in addressing the problems of health disparities and to facilitate the translation of advances in breast cancer, prostate cancer and Type 2 diabetes to underserved communities. Fulfilling this objective will result in an army of trained and LLU certified "Promotores" engaged in prevention education program to reduce the burden of health disparities diseases in this underserved region of California. Accomplishment of these objectives will make the LLU CHDR/CHDMM an established resource for excellence in research, training and successful partnership. .