Intestinal FABP, dietary fat and Type 2 diabetes in Mexican Americans

肠脂肪酸结合蛋白2（FABP 2）具有功能性单核苷酸多态性，Ala 54 Thr 这导致两种蛋白变体：FABP 2 Ala 54和FABP 2 Thr 54。FABP 2 Thr 54变体表现出双重功能。 与FABP 2 Ala 54正常相比，脂肪酸结合增加增加， 携带者可能表现出更高的胰岛素抵抗和空腹血糖水平的风险。效果 Ala 54 Thr SNP在墨西哥裔美国人中尚未得到很好的表征，最近的数据表明， 2型糖尿病（T2 DM）的发病率。此外，大约60%的墨西哥裔美国人 在我们的糖尿病教育计划中，糖尿病参与者是FABP 2 Thr 54携带者， 有机会评估这种高发病率是否可能导致疾病的严重程度。本研究旨在 了解FABP 2 Thr 54在墨西哥裔美国T2 DM患者中的作用。此外，我们将评估 旨在抵消FABP 2 54 Thr潜在负面影响的生活方式干预的效果 参与者的变化。苏氨酸携带者（AT/TT基因型）的个体可能存在不同的相互作用 与膳食脂肪，并可能提供一个独特的机会，发展成功的个性化文化 有效的生活方式干预措施，以减少疾病对墨西哥裔美国人和其他 受影响的群体。我们的中心假设是墨西哥裔美国人表现出一种苏氨酸携带者悖论 受FABP 2 Ala 54 Thr多态性调节。申请的三个目标是：目标1是 FABP 2 Ala 54 Thr多态性对MA患者空腹血糖和血脂水平的影响 有和没有T2 DM。目的2是确定FABP 2 Ala 54 Thr多态性对饱和的 脂肪酸诱导的脂毒性。目的3：确定膳食脂肪与FABP 2基因Ala 54 Thr多态性的关系 墨西哥裔美国糖尿病患者空腹血糖和血脂水平的相互作用。完成 这些目标将增加我们对这种SNP对墨西哥T2 DM健康差异影响的了解 并可能作为未来个性化预防糖尿病发展的基础 针对这一民族的教育计划。

Intestinal fatty acid binding protein 2 (FABP2) exhibits a functional single nucleotide polymorphism, Ala54Thr that result in two protein variants: FABP2 Ala54 and FABP2 Thr54. The FABP2 Thr54 variant exhibits a twofold increase in fatty acid binding compared to the FABP2 Ala54 normal increase fat absorption in the intestine, and carriers may show higher risk for insulin resistance and fasting blood glucose levels. The effect of the Ala54Thr SNP has not been well characterized in Mexican Americans and recent data suggest it is associated with type 2 diabetes (T2DM) in this ethnic group. Further, about 60% of Mexican American diabetic participants in our diabetes education program are FABP2 Thr54 carriers which provide an opportunity to assess if this high incidence may contribute to the severity of the disease. This study seeks to understand the effect of the FABP2 Thr54 in Mexican Americans with T2DM. Further, we will evaluate the effect of a lifestyle intervention designed to counteract the potential negative effect ofthe FABP2 54Thr variant in participants. Individuals shown to be threonine carriers (AT/TT genotypes) may interact differently with dietary fat and may provide an unique opportunity to develop successful personalized cultural competent lifestyle interventions to reduce the impact of the disease on Mexican Americans and other affected groups. Our central hypothesis is that Mexican Americans exhibit a threonine-carrier paradox modulated by the FABP2 Ala54Thr polymorphism. The three aims of the application are: Aim 1 is to determine the effect ofthe FABP2 Ala54Thr polymorphism on fasting blood glucose and lipid levels in MA with and without T2DM. Aim 2 is to determine the effect of the FABP2 Ala54Thr polymorphism on saturated fatty acid-induced lipotoxicity. Aim 3 is to determine the dietary fat and FABP2 Ala54Thr polymorphism interactions on fasting blood glucose and lipids levels in diabetic Mexican-Americans. The completion of these aims will increase our knowledge of the effects of this SNP in T2DM health disparities in Mexican Americans and may serve as foundation for the development of future personalized prevention diabetes education program targeting this ethnic group.