Loma Linda University Center for Health Disparities Res*

描述（由申请人提供）：一个世纪以来，洛马琳达大学（LLU）在加州内陆帝国（IE）的医疗保健和教育方面发挥了重要作用。这些年来，LLU一直支持唯一的医疗和公共卫生学校，为超过300万人的高度多样化的社区提供服务。本申请提出了在该地区建立第一个健康差异研究中心的计划。这个为期五年的项目提出了一项创新计划，将关于健康差距的转化生物医学和基于社区的跨学科研究与基于社区的参与性研究、社区外联和教育伙伴关系以及代表性不足的科学家的培训和发展相结合。这一应用的长期目标是通过建立LLUCHDR加速消除健康差距。行政核心将提供领导力，凝聚力和远见，建立必要的基础设施，以发展和加强LLU的能力，专注于健康差距研究。 它将提供所需的理解规则，以整合来自医学院，研究生院和公共卫生学院的研究人员，他们拥有通过研究，培训和推广消除健康差距的共同目标。研究核心（RC）将支持基础转化研究，最终目标是制定干预措施，以调节由膳食脂肪引发的“细胞氧化应激增强状态”（ASCOS），这是一种严重影响少数群体的风险因素。对乳腺癌、前列腺癌、胰腺癌、糖尿病和中风的研究将集中在阐明这些疾病的发展是如何通过ASCOS相关信号通路介导的。驻地协调员还将支持研究项目，以了解与这些疾病相关的文化能力和获得保健的机会。研究培训和教育核心将把目前的健康差距培训方案与CHDR的倡议相结合，以扩大对高中生和本科生健康差距研究的渠道。社区外展和社区伙伴关系核心（COCPC）将扩大与内陆帝国主要社区和政府实体的现有方案。LLUCHDR将作为整个地区的主要资源，帮助研究人员与社区利益相关者合作，减少或消除IE和国家的健康差距。

DESCRIPTION (provided by applicant): For a century, Loma Linda University (LLU) has played a major role in health care access and education in the Inland Empire (IE), California. For all these years LLU has supported the only medical and public health schools servicing a highly diverse community of more than three million people. The present application proposes a plan to establish the first Center for Health Disparities Research (CHDR) in the region. The five-year project proposes an innovative plan to integrate translational biomedical and community-based interdisciplinary research on health disparities with community based participatory research, partnerships for community outreach and education, and training and development of underrepresented scientists. The long-term goal of this application is to hasten the elimination of health disparities by the establishment of the LLUCHDR. The Administrative Core will provide leadership, cohesiveness and vision for the establishment of the required infrastructure to develop and strengthen LLU's capacity to focus on health disparity research. It will provide the required rules of understanding to integrate researchers from the School of Medicine, Graduate School, and the School of Public Health who share the common goal to eliminate health disparities through research, training, and outreach. The Research Core (RC) will support basic translational research with the final goal to develop interventions to modulate the "augmented state of cellular oxidative stress" (ASCOS) triggered by dietary fat, a risk factor that is seriously affecting minority populations. Studies on breast, prostate, and pancreatic cancer, diabetes, and stroke will be focused on elucidating how the development of these diseases is mediated through ASCOS-associated signaling pathways. The RC will also support research projects to understand elements of cultural competence and health care access associated with these conditions. The Research Training and Educational Core (RTEC) will integrate current health disparity training programs with the CHDR's initiative to widen the pipeline to high school & undergraduate students in health disparities research. The Community Outreach and Community Partnerships Core (COCPC) will expand existing programs with key community and government entities in the Inland Empire. The LLUCHDR will serve as a major resource for the whole region that will help researchers work with community stakeholders to reduce or eliminate health disparities in the IE and the country.