Co-Morbid Opioid Addiction and Chronic Pain

描述(申请者提供)：阿片成瘾与慢性疼痛共病阿片成瘾与慢性疼痛摘要这项由K23指导的以患者为导向的研究职业发展奖的主要目的是为临床健康心理学家艾米·沃赫霍尔茨博士提供所需的高级研究培训、受保护的研究时间和指导经验，使她成为一名独立研究人员，开发和评估阿片成瘾和慢性疼痛的创新治疗方法，这些方法是综合的(药物疗法和心理社会治疗)和新颖的(CBT和自我调节技术)。候选人提出了一项实现这一职业目标的研究和培训计划，包括：1)发展关于阿片成瘾和疼痛之间的心理和生理相互作用的知识，2)增加她对成瘾的心理和药物治疗方法的知识，3)建立心理-社会治疗发展的技能，4)加强她对先进统计技术的理解，以及5)建立赠款编写和赠款管理方面的专业知识。Wachholtz博士将由她的主要导师Gerardo Gonzalez医学博士和两位共同导师Douglas Ziedonis医学博士和Martin Cheatle博士指导。瓦赫霍尔茨博士将在共病疼痛和阿片成瘾领域进行两项截然不同的研究。第一项研究(疼痛反应研究)是一项实验室研究，涉及120名参与者；90名阿片成瘾和慢性疼痛患者，以确定接受美沙酮阿片成瘾维持治疗的阿片成瘾患者(30名)、有阿片成瘾史但长期戒断阿片(6个月)的丁丙诺啡阿片维持治疗患者(30名)和30名阿片类幼稚患者对诱导疼痛的独特生理、心理和行为反应。根据第一项研究的结果，第二项研究(干预研究)将对30名受试者进行CBT自我调节心理社会综合治疗，以减少药物使用，减少疼痛，并降低对疼痛和痛苦的生理反应。结果将为未来的R01应用程序提供信息，以测试共病疼痛和阿片成瘾的综合治疗。成功完成这项K23奖项将推动Wachholtz博士进入独立研究人员的职业生涯，他拥有进行临床研究试验的专业知识，以改进对共病阿片成瘾和疼痛的治疗。

DESCRIPTION (provided by applicant): Co-Morbid Opioid Addiction and Chronic Pain ABSTRACT The primary goal of this K23 - Mentored Patient-Oriented Research Career Development Award is to provide Dr. Amy Wachholtz, a clinical health psychologist, with the advanced research training, protected time for research, and mentored experiences necessary for her to become an independent researcher in developing and evaluating innovative treatments for opioid addiction and co-morbid pain that are integrative (pharmacotherapy and psychosocial treatment) and novel (CBT and Self-Regulation Techniques). The candidate proposes a program of research and training to meet this career goal including: 1) developing knowledge about the psychological and physiological interactions between opioid addiction and pain , 2) increasing her knowledge about psychological and pharmacological treatment approaches to addiction, 3) building skills in psycho-social treatment development, 4) enhancing her understanding of advanced statistical techniques, and 5) building expertise in grant writing and grant administration. Dr. Wachholtz will be guided by her primary mentor, Gerardo Gonzalez, MD, and two co-mentors, Douglas Ziedonis, MD, MPH, and Martin Cheatle, PhD. Dr. Wachholtz will conduct two distinct studies in the area of co-morbid pain and opioid addiction. The first study (Pain Reactivity Study) is a laboratory study of 120 participants; 90 with opioid addiction and chronic pain to identify the unique physiological, psychological, and behavioral responses to induced pain among those on methadone opioid maintenance treatment for opioid addiction (30 participants); on buprenorphine opioid maintenance treatment (30 participants), with an opioid addiction history but prolonged abstinence (6+ months) from opioids (30 participants), and 30 opioid naive participants. Based on findings from the first study, the second study (Intervention Study) will develop and pilot test 30 subjects in an integrated CBT + Self-Regulation psycho-social treatment for co-morbid opioid addiction and pain to decrease substance use, reduce pain, and decrease physiological reactivity to pain and distress. Results will inform a future R01 application to test an integrated treatment for co-morbid pain and opioid addiction. Successful completion of this K23 award will advance Dr. Wachholtz into a career as an independent researcher with the expertise to conduct clinical research trials to improve treatment for co-morbid opioid addiction and pain.