Co-Morbid Opioid Addiction and Chronic Pain

共病阿片类药物成瘾和慢性疼痛

• 批准号: 9391945
• 负责人: AMY B WACHHOLTZ
• 金额: $ 8.6万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9391945
• 关键词: Co; Morbid; Opioid; Addiction; Chronic

Co-Morbid Opioid Addiction and Chronic Pain ABSTRACT The primary goal of this K23 – Mentored Patient-Oriented Research Career Development Award is to provide Dr. Amy Wachholtz, a clinical health psychologist, with the advanced research training, protected time for research, and mentored experiences necessary for her to become an independent researcher in developing and evaluating innovative treatments for opioid addiction and co-morbid pain that are integrative (pharmacotherapy and psychosocial treatment) and novel (CBT and Self-Regulation Techniques). The candidate proposes a program of research and training to meet this career goal including: 1) developing knowledge about the psychological and physiological interactions between opioid addiction and pain , 2) increasing her knowledge about psychological and pharmacological treatment approaches to addiction, 3) building skills in psycho-social treatment development, 4) enhancing her understanding of advanced statistical techniques, and 5) building expertise in grant writing and grant administration. Dr. Wachholtz will be guided by her primary mentor, Gerardo Gonzalez, MD, and two co-mentors, Douglas Ziedonis, MD, MPH, and Martin Cheatle, PhD. Dr. Wachholtz will conduct two distinct studies in the area of co-morbid pain and opioid addiction. The first study (Pain Reactivity Study) is a laboratory study of 120 participants; 90 with opioid addiction and chronic pain to identify the unique physiological, psychological, and behavioral responses to induced pain among those on methadone opioid maintenance treatment for opioid addiction (30 participants); on buprenorphine opioid maintenance treatment (30 participants), with an opioid addiction history but prolonged abstinence (6+ months) from opioids (30 participants), and 30 opioid naïve participants. Based on findings from the first study, the second study (Intervention Study) will develop and pilot test 30 subjects in an integrated CBT + Self-Regulation psycho-social treatment for co-morbid opioid addiction and pain to decrease substance use, reduce pain, and decrease physiological reactivity to pain and distress. Results will inform a future R01 application to test an integrated treatment for co-morbid pain and opioid addiction. Successful completion of this K23 award will advance Dr. Wachholtz into a career as an independent researcher with the expertise to conduct clinical research trials to improve treatment for co-morbid opioid addiction and pain.

共病阿片类药物成瘾和慢性疼痛 抽象的 K23——以患者为导向的研究职业发展奖的主要目标是提供 Amy Wachholtz 博士是一位临床健康心理学家，接受过高级研究培训，为您节省了时间 研究，并为她提供了成为一名独立研究员所必需的指导经验 评估阿片类药物成瘾和共病疼痛的综合创新疗法 （药物疗法和心理社会治疗）和新颖的（CBT 和自我调节技术）。这 候选人提出一个研究和培训计划来实现这一职业目标，包括：1）开发 关于阿片类药物成瘾和疼痛之间心理和生理相互作用的知识，2) 增加她对成瘾心理和药物治疗方法的了解，3) 培养心理社会治疗发展技能，4) 增强她对高级统计的理解 技术，5) 建立拨款写作和拨款管理方面的专业知识。 Wachholtz 博士将接受以下指导： 她的主要导师 Gerardo Gonzalez（医学博士）和两位共同导师 Douglas Ziedonis（医学博士、公共卫生硕士）和 Martin 查特尔，博士。 Wachholtz 博士将在共病疼痛和阿片类药物领域进行两项不同的研究 瘾。第一项研究（疼痛反应性研究）是一项有 120 名参与者参与的实验室研究； 90 含阿片类药物 成瘾和慢性疼痛，以确定独特的生理、心理和行为反应 因阿片类药物成瘾而接受美沙酮阿片类药物维持治疗的患者中诱发疼痛（30 名参与者）； 接受丁丙诺啡阿片类药物维持治疗（30 名参与者），有阿片类药物成瘾史，但 长期戒除阿片类药物（6 个月以上）（30 名参与者）和 30 名未使用阿片类药物的参与者。基于 根据第一项研究的结果，第二项研究（干预研究）将开发并试点测试 30 名受试者 综合 CBT + 自我调节心理社会治疗可减少阿片类药物成瘾共病和疼痛 物质使用，减轻疼痛，并减少对疼痛和痛苦的生理反应。结果将告知 未来的 R01 应用将测试针对共病疼痛和阿片类药物成瘾的综合治疗。成功的 完成 K23 奖项将使 Wachholtz 博士成为一名独立研究员， 进行临床研究试验的专业知识，以改善对共病阿片类药物成瘾和疼痛的治疗。

项目成果

The benefit of heart rate variability biofeedback and relaxation training in reducing trait anxiety.

• DOI: 10.17315/kjhp.2015.20.2.002
• 发表时间: 2015-01-01
• 期刊: Han'guk Simni Hakhoe chi. Kon'gang = The Korean journal of health psychology
• 作者: Lee, Jieun;Kim, Jung K;Wachholtz, Amy
• 通讯作者: Wachholtz, Amy

Meaning in life in chronic pain patients over time: associations with pain experience and psychological well-being.

• DOI: 10.1007/s10865-014-9614-1
• 发表时间: 2015-04
• 期刊: JOURNAL OF BEHAVIORAL MEDICINE
• 影响因子: 3.1
• 作者: Dezutter, Jessie;Luyckx, Koen;Wachholtz, Amy
• 通讯作者: Wachholtz, Amy

A reanalysis of a randomized trial on meditation for migraine headaches: Distraction is not enough but meditation takes time.

对冥想治疗偏头痛的随机试验的重新分析：分散注意力是不够的，但冥想需要时间。

• DOI: 10.1016/j.ctim.2019.08.011
• 发表时间: 2019
• 期刊: Complementary therapies in medicine
• 影响因子: 3.6
• 作者: Wachholtz,Amy;Vohra,Rini;Metzger,Aaron
• 通讯作者: Metzger,Aaron

Co-morbid pain and opioid addiction: long term effect of opioid maintenance on acute pain.

共病疼痛和阿片类药物成瘾：阿片类药物维持对急性疼痛的长期影响。

• DOI: 10.1016/j.drugalcdep.2014.10.010
• 发表时间: 2014
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Wachholtz,Amy;Gonzalez,Gerardo
• 通讯作者: Gonzalez,Gerardo

Intersection of chronic pain treatment and opioid analgesic misuse: causes, treatments, and policy strategies.

慢性疼痛治疗和阿片类镇痛药滥用的交叉点：原因、治疗和政策策略。

• DOI: 10.2147/sar.s12944
• 发表时间: 2011
• 期刊: Substance abuse and rehabilitation
• 影响因子: 1.8
• 作者: Wachholtz,Amy;Gonzalez,Gerardo;Boyer,Edward;Naqvi,ZafarN;Rosenbaum,Christopher;Ziedonis,Douglas
• 通讯作者: Ziedonis,Douglas