Co-Morbid Opioid Addiction and Chronic Pain

描述（申请人提供）：共同病态阿片类药物成瘾和慢性疼痛摘要这个K23指导的以患者为导向的研究职业发展奖的主要目标是为临床健康心理学家Amy Wachholtz博士提供先进的研究培训，保护研究时间，并指导了她成为独立研究人员所需的经验，以开发和评估阿片类药物成瘾和共同综合性（药物治疗和心理治疗）和新型（CBT和自我调节技术）的病态疼痛。候选人提出了一个研究和培训计划，以满足这一职业目标，包括：1）发展关于阿片类药物成瘾和疼痛之间的心理和生理相互作用的知识，2）增加她对成瘾的心理和药理治疗方法的知识，3）建立心理社会治疗发展的技能，4）增强她对先进统计技术的理解，以及5）培养撰写和管理赠款的专门知识。Wachholtz博士将由她的主要导师Gerardo Gonzalez博士和两位共同导师道格拉斯Ziedonis博士和Martin Cheatle博士指导。Wachholtz博士将在共病疼痛和阿片类药物成瘾领域进行两项不同的研究。第一项研究疼痛反应性研究（Pain Reactivity Study）是一项针对120名参与者的实验室研究，其中90名患有阿片类药物成瘾和慢性疼痛，以确定接受美沙酮阿片类药物维持治疗的阿片类药物成瘾者对诱发疼痛的独特生理，心理和行为反应。（30名与会者）;丁丙诺啡阿片类药物维持治疗（30名参与者），有阿片类药物成瘾史，但长期戒断阿片类药物（30名参与者），以及30名阿片类药物初治参与者。基于第一项研究的结果，第二项研究（干预研究）将开发和试点测试30名受试者，进行综合CBT +自我调节心理社会治疗，以减少物质使用，减轻疼痛，并减少对疼痛和痛苦的生理反应。结果将为未来的R 01应用提供信息，以测试合并症疼痛和阿片类药物成瘾的综合治疗。成功完成K23奖项将使Wachholtz博士成为一名独立研究人员，拥有开展临床研究试验的专业知识，以改善对阿片类药物成瘾和疼痛的治疗。

DESCRIPTION (provided by applicant): Co-Morbid Opioid Addiction and Chronic Pain ABSTRACT The primary goal of this K23 - Mentored Patient-Oriented Research Career Development Award is to provide Dr. Amy Wachholtz, a clinical health psychologist, with the advanced research training, protected time for research, and mentored experiences necessary for her to become an independent researcher in developing and evaluating innovative treatments for opioid addiction and co-morbid pain that are integrative (pharmacotherapy and psychosocial treatment) and novel (CBT and Self-Regulation Techniques). The candidate proposes a program of research and training to meet this career goal including: 1) developing knowledge about the psychological and physiological interactions between opioid addiction and pain , 2) increasing her knowledge about psychological and pharmacological treatment approaches to addiction, 3) building skills in psycho-social treatment development, 4) enhancing her understanding of advanced statistical techniques, and 5) building expertise in grant writing and grant administration. Dr. Wachholtz will be guided by her primary mentor, Gerardo Gonzalez, MD, and two co-mentors, Douglas Ziedonis, MD, MPH, and Martin Cheatle, PhD. Dr. Wachholtz will conduct two distinct studies in the area of co-morbid pain and opioid addiction. The first study (Pain Reactivity Study) is a laboratory study of 120 participants; 90 with opioid addiction and chronic pain to identify the unique physiological, psychological, and behavioral responses to induced pain among those on methadone opioid maintenance treatment for opioid addiction (30 participants); on buprenorphine opioid maintenance treatment (30 participants), with an opioid addiction history but prolonged abstinence (6+ months) from opioids (30 participants), and 30 opioid naive participants. Based on findings from the first study, the second study (Intervention Study) will develop and pilot test 30 subjects in an integrated CBT + Self-Regulation psycho-social treatment for co-morbid opioid addiction and pain to decrease substance use, reduce pain, and decrease physiological reactivity to pain and distress. Results will inform a future R01 application to test an integrated treatment for co-morbid pain and opioid addiction. Successful completion of this K23 award will advance Dr. Wachholtz into a career as an independent researcher with the expertise to conduct clinical research trials to improve treatment for co-morbid opioid addiction and pain.