Co-Morbid Opioid Addiction and Chronic Pain

描述（由申请人提供）：阿片类药物成瘾和慢性疼痛 摘要 该 K23 - 指导患者导向研究职业发展奖的主要目标是为临床健康心理学家 Amy Wachholtz 博士提供先进的研究培训、受保护的研究时间和指导经验，使她成为一名独立研究人员，开发和评估阿片类药物成瘾和共病疼痛的创新治疗方法，这些治疗是综合性的（药物疗法）和心理社会治疗）和新颖（CBT 和自我调节技术）。候选人提出了一项研究和培训计划，以实现这一职业目标，包括：1）发展有关阿片类药物成瘾和疼痛之间心理和生理相互作用的知识，2）增加对成瘾心理和药物治疗方法的了解，3）培养心理社会治疗开发技能，4）增强对先进统计技术的理解，5）建立拨款写作和拨款管理方面的专业知识。 Wachholtz 博士将受到她的主要导师 Gerardo Gonzalez（医学博士）和两位共同导师 Douglas Ziedonis（医学博士、公共卫生硕士）和 Martin Cheatle（博士）的指导。 Wachholtz 博士将在共病疼痛和阿片类药物成瘾领域进行两项不同的研究。第一项研究（疼痛反应性研究）是一项有 120 名参与者参与的实验室研究； 90 名阿片类药物成瘾和慢性疼痛，以确定接受美沙酮阿片类药物成瘾维持治疗的患者对诱发疼痛的独特生理、心理和行为反应（30 名参与者）；接受丁丙诺啡阿片类药物维持治疗（30 名参与者），有阿片类药物成瘾史但长期戒除阿片类药物（6 个月）（30 名参与者），以及 30 名未使用阿片类药物的参与者。根据第一项研究的结果，第二项研究（干预研究）将开发并试点测试 30 名受试者，对共病阿片类药物成瘾和疼痛进行综合 CBT 自我调节心理社会治疗，以减少物质使用、减轻疼痛并减少对疼痛和痛苦的生理反应。结果将为未来的 R01 应用提供信息，以测试共病疼痛和阿片类药物成瘾的综合治疗方法。成功完成 K23 奖项将使 Wachholtz 博士成为一名独立研究员，拥有开展临床研究试验的专业知识，以改善阿片类药物成瘾和疼痛共病的治疗。

DESCRIPTION (provided by applicant): Co-Morbid Opioid Addiction and Chronic Pain ABSTRACT The primary goal of this K23 - Mentored Patient-Oriented Research Career Development Award is to provide Dr. Amy Wachholtz, a clinical health psychologist, with the advanced research training, protected time for research, and mentored experiences necessary for her to become an independent researcher in developing and evaluating innovative treatments for opioid addiction and co-morbid pain that are integrative (pharmacotherapy and psychosocial treatment) and novel (CBT and Self-Regulation Techniques). The candidate proposes a program of research and training to meet this career goal including: 1) developing knowledge about the psychological and physiological interactions between opioid addiction and pain , 2) increasing her knowledge about psychological and pharmacological treatment approaches to addiction, 3) building skills in psycho-social treatment development, 4) enhancing her understanding of advanced statistical techniques, and 5) building expertise in grant writing and grant administration. Dr. Wachholtz will be guided by her primary mentor, Gerardo Gonzalez, MD, and two co-mentors, Douglas Ziedonis, MD, MPH, and Martin Cheatle, PhD. Dr. Wachholtz will conduct two distinct studies in the area of co-morbid pain and opioid addiction. The first study (Pain Reactivity Study) is a laboratory study of 120 participants; 90 with opioid addiction and chronic pain to identify the unique physiological, psychological, and behavioral responses to induced pain among those on methadone opioid maintenance treatment for opioid addiction (30 participants); on buprenorphine opioid maintenance treatment (30 participants), with an opioid addiction history but prolonged abstinence (6+ months) from opioids (30 participants), and 30 opioid naive participants. Based on findings from the first study, the second study (Intervention Study) will develop and pilot test 30 subjects in an integrated CBT + Self-Regulation psycho-social treatment for co-morbid opioid addiction and pain to decrease substance use, reduce pain, and decrease physiological reactivity to pain and distress. Results will inform a future R01 application to test an integrated treatment for co-morbid pain and opioid addiction. Successful completion of this K23 award will advance Dr. Wachholtz into a career as an independent researcher with the expertise to conduct clinical research trials to improve treatment for co-morbid opioid addiction and pain.