Hippocampal inhibitory control of contextual fear learning

描述（由申请人提供）：由于脑回路病理引起的适应不良恐惧反应已广泛涉及几种精神疾病，如创伤后应激障碍（PTSD），焦虑和恐慌障碍。因此，对这些疾病的临床解决方案需要对实现这些记忆功能的神经回路的基本结构和功能有更深入的了解。在这里，我们建议应用新技术-细胞分辨率功能神经成像和基因鉴定的细胞类型特异性操作

DESCRIPTION (provided by applicant): Maladaptive fear responses due to brain circuit pathology have been widely implicated in several psychiatric disorders such as post-traumatic stress disorder (PTSD), anxiety, and panic disorders. Clinical solutions to these disorders thus require a greater understanding of the basic structure and function of neural circuits implementing these memory functions. Here we propose to apply new technologies - cellular-resolution functional neural imaging and cell type-specific manipulations of genetically identified hippocampal circuits in behaving mice - for studying contextual fear learning and storage. Our result will inform our basic understanding of how we learn and remember, and suggest specific targets for treatment and rehabilitation of maladaptive fear responses in disorders of fear, anxiety, and memory.