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Hippocampal inhibitory control of contextual fear learning

海马对情境恐惧学习的抑制控制

基本信息

批准号：
8806604
负责人：
Attila Losonczy
金额：
$ 39.59万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-03-01 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8806604
关键词：
Air Amygdaloid structure Animals Anxiety Basic Science Brain Cell Nucleus Clinical Complement Conditioned Reflex Conditioned Stimulus Data Dendrites Detection Disease Ensure Environment Event Evolution Fright Functional Imaging Head Health Hippocampus (Brain)Human Human Pathology Image Indium Interneurons Investigation Knowledge Lead Learning Mediating Memory Memory impairment Mental disorders Methods Modality Monitor Mus Neurophysiology - biologic function Neurotransmitter Receptor Output Panic Panic Disorder Pathology Performance Pharmacogenetics Play Population Population Dynamics Post-Traumatic Stress Disorders Preparation Presynaptic Terminals Pyramidal Cells Rehabilitation therapy Resolution Rodent Role Sensory Solutions Source Stimulus Structure Synapses Testing Variant anxiety treatment base cell type conditioned fear experience fear memory in vivo insight multisensory neural circuit neuroregulation new technology optogenetics prevent relating to nervous system research study response sensory input two-photon

项目摘要

DESCRIPTION (provided by applicant): Maladaptive fear responses due to brain circuit pathology have been widely implicated in several psychiatric disorders such as post-traumatic stress disorder (PTSD), anxiety, and panic disorders. Clinical solutions to these disorders thus require a greater understanding of the basic structure and function of neural circuits implementing these memory functions. Here we propose to apply new technologies - cellular-resolution functional neural imaging and cell type-specific manipulations of genetically identified hippocampal circuits in behaving mice - for studying contextual fear learning and storage. Our result will inform our basic understanding of how we learn and remember, and suggest specific targets for treatment and rehabilitation of maladaptive fear responses in disorders of fear, anxiety, and memory.

描述（由申请人提供）：由于脑回路病理导致的适应不良恐惧反应已广泛涉及多种精神疾病，例如创伤后应激障碍（PTSD）、焦虑和恐慌症。因此，这些疾病的临床解决方案需要更好地理解实现这些记忆功能的神经回路的基本结构和功能。在这里，我们建议应用新技术-细胞分辨率功能神经成像和细胞类型特异性操作的遗传鉴定，行为小鼠的海马回路-用于研究情境恐惧学习和存储。我们的研究结果将告知我们如何学习和记忆的基本理解，并为恐惧，焦虑和记忆障碍中的适应不良恐惧反应的治疗和康复提出具体目标。