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Hippocampal inhibitory control of contextual fear learning

海马对情境恐惧学习的抑制控制

基本信息

批准号：
9003081
负责人：
Attila Losonczy
金额：
$ 39.59万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-03-01 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9003081
关键词：
Accelerometer Air Amygdaloid structure Animals Anxiety Basic Science Brain Cell Nucleus Clinical Complement Conditioned Reflex Conditioned Stimulus Data Dendrites Detection Disease Electrophysiology (science)Ensure Environment Event Evolution Fright Functional Imaging Head Health Hippocampus (Brain)Human Human Pathology Image Indium Interneurons Investigation Knowledge Lead Learning Mediating Memory Memory impairment Mental disorders Methods Modality Mus Neurophysiology - biologic function Neurotransmitter Receptor Output Panic Panic Disorder Pathology Performance Pharmacogenetics Play Population Population Dynamics Post-Traumatic Stress Disorders Preparation Presynaptic Terminals Pyramidal Cells Rehabilitation therapy Resolution Rodent Role Sensory Source Stimulus Structure Synapses Testing Variant anxiety treatment base cell type conditioned fear experience fear memory in vivo insight multisensory neural circuit neuroregulation new technology optogenetics prevent relating to nervous system research study response sensory input two-photon

项目摘要

DESCRIPTION (provided by applicant): Maladaptive fear responses due to brain circuit pathology have been widely implicated in several psychiatric disorders such as post-traumatic stress disorder (PTSD), anxiety, and panic disorders. Clinical solutions to these disorders thus require a greater understanding of the basic structure and function of neural circuits implementing these memory functions. Here we propose to apply new technologies - cellular-resolution functional neural imaging and cell type-specific manipulations of genetically identified hippocampal circuits in behaving mice - for studying contextual fear learning and storage. Our result will inform our basic understanding of how we learn and remember, and suggest specific targets for treatment and rehabilitation of maladaptive fear responses in disorders of fear, anxiety, and memory.

描述(由申请人提供)：由大脑回路病理引起的适应不良恐惧反应被广泛地与几种精神障碍有关，如创伤后应激障碍(PTSD)、焦虑和恐慌症。因此，这些疾病的临床解决方案需要更多地了解实现这些记忆功能的神经回路的基本结构和功能。在这里，我们建议应用新技术-细胞分辨率功能神经成像和特定细胞类型的基因识别操作表现良好的小鼠的海马区--用于研究背景恐惧的学习和储存。我们的结果将使我们对学习和记忆的方式有基本的了解，并为治疗和康复恐惧、焦虑和记忆障碍中的适应不良恐惧反应提出具体的目标。