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Path to Improved Risk Stratification

改进风险分层的途径

基本信息

批准号：
8719852
负责人：
JEFFREY J GOLDBERGER
金额：
$ 1万
依托单位：
PATH TO IMPROVED RISK STRATIFICATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8719852
关键词：
Address Area Attention Cessation of life Chicago Clinical Clinical Trials Collaborations Communication Coronary Arteriosclerosis Development Economics Educational workshop Epidemiology Ethics Event Fostering Goals Government Agencies Health Services Research Heart Arrest Hospitals Individual Industry Institutes Investments Knowledge Mission National Heart, Lung, and Blood Institute Outcomes Research Participant Patient-Focused Outcomes Patients Physicians Prevention Prevention strategy Public Health Reporting Research Research Institute Research Personnel Resuscitation Risk Societies Stratification Techniques Teleconferences Testing Time United States United States Centers for Medicare and Medicaid Services United States Food and Drug Administration Update Ventricular Fibrillation Ventricular Tachycardia Washington Work design experience health care quality health economics heuristics improved innovation knowledge base meetings member public health relevance sound success sudden cardiac death symposium tool

项目摘要

Sudden cardiac death is a major public health problem with approximately 180,000 to 400,000 deaths annually. Because of the low efficacy and success rates of out-of- hospital resuscitation, a high priority has been set to try and identify individuals at risk for sudden cardiac death prior to the event. If this can be done, there are treatments that can be instituted to mitigate this risk. However, despite decades of research, and significant investments of time, effort, and research dollars, there is not yet an ideal or even acceptable approach to risk stratification for sudden cardiac death. One approach that could be initiated to engender more rapid progress in this area is to promote better coordination among the various stakeholders - investigators, government agencies, and industry. Although all are vested in the need for risk stratification, each group has different sets of priorities and therefore approaches the problem from different perspectives. The Path to Improved Risk Stratification, NFP is a not-for-profit think tank founded by Dr. Jeffrey Goldberger whose mission is to serve as a focal point to help organize a rational, coordinated plan for developing, evaluating, and implementing risk stratification strategies for prevention of sudden cardiac death. The Path to Improved Risk Stratification, NFP has organized annual single day meetings in Chicago for the last eight years with: 1) physician leaders in the area of risk stratification, clinical trials in prevention of sudden cardiac death, epidemiology, and health economics; 2) representatives from the relevant government agencies; 3) representatives from industry. The meeting agendas are designed to identify important gaps in our knowledge and to strategize how those gaps can best be filled. These meetings have resulted in new efforts in risk stratification and have helped guide some clinical trials that have been in development. The agenda for each meeting is to evaluate progress from the prior meeting, review new information relevant to risk stratification, discuss issues related to ongoing clinical trials, obtain updates on planning of new trials, review scientific/statistical/economics issues related to risk stratification, and explore new areas that are gaps in our knowledge base. Given the vastness of the information that needs to be understood to advance the field of risk stratification, this effort provides an important sounding board for those involved and encourages collaboration and the development of innovative approaches.

心源性猝死是一个重大的公共卫生问题，大约有 180,000 人死于心源性猝死。 400,000 deaths annually.由于外治的疗效和成功率较低医院复苏，已设置高度优先事项来尝试识别处于危险中的个人事件发生前的心源性猝死。如果可以做到这一点，就有治疗方法可以采取这样的措施来减轻这种风险。然而，尽管经过数十年的研究，投入了大量的时间、精力和研究资金，目前还没有一个理想的或甚至可以接受的心源性猝死风险分层方法。一种方法为了在这一领域取得更快的进展，可以采取的行动是促进更好的各利益相关方之间的协调——调查人员、政府机构和行业。尽管所有人都需要进行风险分层，但每个组都有不同的优先级，因此从不同的角度处理问题观点。改善风险分层的途径，NFP 是一个非营利性智囊团由 Jeffrey Goldberger 博士创立，其使命是充当帮助中心组织合理、协调的计划来制定、评估和实施预防心源性猝死的风险分层策略。改善风险分层之路，NFP 组织了年度单日活动过去八年在芝加哥与以下人士举行会议：1) 风险领域的医生领导者分层、预防心源性猝死的临床试验、流行病学和 health economics; 2）有关政府机构的代表； 3）来自业界的代表。会议议程旨在确定重要事项我们的知识差距，并制定如何最好地填补这些差距的战略。这些会议在风险分层方面做出了新的努力，并帮助指导了一些已经在开发中的临床试验。每次会议的议程是评估上次会议的进展，审查与风险相关的新信息分层，讨论与正在进行的临床试验相关的问题，获取规划的更新新试验，审查与风险分层相关的科学/统计/经济学问题，并探索我们知识库中空白的新领域。鉴于幅员辽阔需要理解以推进风险分层领域的信息，这努力为参与者提供了一个重要的共鸣板，并鼓励合作和创新方法的开发。