2014 Mutagenesis Gordon Research Conference

描述(由申请人提供)： 2014年戈登突变研究会议的题目是《遗传格局的变化，从单核苷酸到整个基因组》，将聚焦于遗传格局变化的原因和后果。所有生物的基因组都不断地面临着环境压力，特别是来自外部来源的压力。这种环境压力对人类的主要挑战是突变和疾病的风险，包括衰老和与年龄相关的疾病，如癌症和神经退化。此外，生殖系突变会导致遗传性疾病，包括一系列罕见疾病。诱变也有积极的方面，包括它对免疫学和进化的重要贡献。因此，诱变过程及其适当的控制是人类健康的许多方面的基础。突变会议是介绍关于基因变化的潜在机制和健康后果的新研究的主要国际场所。我们的演讲者最近的发现揭示了对突变如何源于促进DNA交易的关键细胞因素的成功或失败的重要新理解。这次会议将突出新的工作，包括广泛的方法，从突变的机制研究，到最近的全基因组分析革命，再到新的治疗方法。所有这些主题都由来自七个国家的30名代表学术界、政府和研究机构的确认演讲者涵盖。将从提交的摘要中挑选另外8名发言者，以便在日程安排中穿插最新的事态发展并突出新的调查人员。日程表包括开幕主旨会议，随后是每日上午和晚上的会议，题为RNA介导的突变；基因组和染色体改变；复制分叉的挑战；编辑和修复；决策点、修复或突变；DNA聚合酶和跨损伤合成；DNA结构挑战；以及定向突变。日程安排还为充满活力的小组讨论以及一对一和小组互动提供了充足的时间。每天的海报会议可以展示额外的工作，并促进学生、博士后研究员、新研究人员和更高级人物之间的直接互动。主要目标是探索诱变研究前沿的现有知识，重点是分子机制和研究这些机制的新方法；确定治疗战略，以加强保持基因组完整性并利用诱变在疾病治疗中的优势；鼓励新的合作，特别是开发跨实验系统和学科的工作；以及促进和促进青年科学家的职业生涯，并鼓励他们在该领域继续下去。位于西班牙巴塞罗那附近的新会场完美地促进了Mutagenesis GRC在欧洲和美国之间轮换会场的传统。该会场将为会议提供全面的访问和支持，本身就是一个重要的吸引潜在与会者的地方。

DESCRIPTION (provided by applicant): The 2014 Gordon Research Conference on Mutagenesis, titled "Changes to the Genetic Landscape, from Single Nucleotides to Entire Genomes", will focus on the causes and consequences of changes to the genetic landscape. The genomes of all organisms are constantly faced with environmental stress, particularly from exogenous sources. A primary challenge of this environmental stress to humans is the risk of mutagenesis and disease, including aging and age-related diseases such as cancer and neurodegeneration. Moreover, germ line mutations confer inherited diseases, including a wide range of rare diseases. There are positive aspects of mutagenesis as well, including its important contributions to immunology and evolution. Thus mutagenic processes, and their appropriate control, underlie many aspects of human health. The Mutagenesis conference is the premiere international venue for presenting new research on the underlying mechanisms and the health consequences of genetic changes. Recent findings by our speakers have revealed important new understanding of how mutagenesis stems from the success-or failure-of key cellular factors in facilitating DNA transactions. The conference will highlight new work encompassing a broad range of approaches, from mechanistic studies of mutagenesis, to the recent revolution in whole-genome analysis, to new therapeutic approaches. All these topics are covered by the 30 confirmed speakers from seven countries and representing academia, government and research institutes. An additional 8 speakers will be selected from submitted abstracts for talks interspersed in the schedule with the latest developments and to highlight new investigators. The schedule includes an opening keynote session, followed by daily morning and evening sessions entitled RNA-mediated mutagenesis; Genomic and chromosomal alterations; Challenges at the replication fork; Editing and repair; Decision points, repair or mutate; DNA polymerases and translesion synthesis; DNA structural challenges; and Targeted mutagenesis. The schedule also provides ample time for vibrant group discussions plus one-on-one and small group interactions. Daily poster sessions enable the presentation of additional work and facilitate direct interaction among students, postdoctoral fellows, new investigators, and more senior figures. Key objectives are to explore current knowledge at the frontier of mutagenesis research, with emphasis on molecular mechanisms and novel approaches to studying these mechanisms; to define therapeutic strategies to enhance the maintenance of genomic integrity and to take advantage of mutagenesis in the treatment of disease; to stimulate novel collaborations, especially exploiting work across experimental systems and disciplines; and to enhance and promote the careers of young scientists and encourage their continuation in the field. The new venue near Barcelona, Spain serves perfectly to further the Mutagenesis GRC tradition of alternating sites between Europe and the U.S. The site will provide full access and support to the conference, and is itself a significant attraction for potential attendees.