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2014 Mutagenesis Gordon Research Conference

2014年诱变戈登研究会议

基本信息

批准号：
8707092
负责人：
Robert S Lahue
金额：
$ 0.9万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-18 至 2015-04-17
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8707092
关键词：
Academia Affect Aging Area Chemicals Chromosome abnormality Collaborations Country DNA DNA Damage DNA Maintenance DNA Repair DNA Sequence DNA biosynthesis DNA-Directed DNA Polymerase Development Discipline Disease Environmental Exposure Europe Evolution Exposure to Failure Fostering Genetic Genome Genomics Germ-Line Mutation Government Health Human Immune response Immunology Inherited International Knowledge Maintenance Malignant Neoplasms Mediating Molecular Mutagenesis Mutate Mutation Nerve Degeneration Nucleotides Organism Pathologic Mutagenesis Postdoctoral Fellow Process RNA Radiation Rare Diseases Research Research Institute Research Personnel Risk Schedule Scientist Site Source Spain Stress Students System Therapeutic Time Work abstracting age related career frontier genome analysis human disease interest meetings novel novel strategies novel therapeutic intervention posters public health relevance repaired research and development stem success symposium

项目摘要

DESCRIPTION (provided by applicant): The 2014 Gordon Research Conference on Mutagenesis, titled "Changes to the Genetic Landscape, from Single Nucleotides to Entire Genomes", will focus on the causes and consequences of changes to the genetic landscape. The genomes of all organisms are constantly faced with environmental stress, particularly from exogenous sources. A primary challenge of this environmental stress to humans is the risk of mutagenesis and disease, including aging and age-related diseases such as cancer and neurodegeneration. Moreover, germ line mutations confer inherited diseases, including a wide range of rare diseases. There are positive aspects of mutagenesis as well, including its important contributions to immunology and evolution. Thus mutagenic processes, and their appropriate control, underlie many aspects of human health. The Mutagenesis conference is the premiere international venue for presenting new research on the underlying mechanisms and the health consequences of genetic changes. Recent findings by our speakers have revealed important new understanding of how mutagenesis stems from the success-or failure-of key cellular factors in facilitating DNA transactions. The conference will highlight new work encompassing a broad range of approaches, from mechanistic studies of mutagenesis, to the recent revolution in whole-genome analysis, to new therapeutic approaches. All these topics are covered by the 30 confirmed speakers from seven countries and representing academia, government and research institutes. An additional 8 speakers will be selected from submitted abstracts for talks interspersed in the schedule with the latest developments and to highlight new investigators. The schedule includes an opening keynote session, followed by daily morning and evening sessions entitled RNA-mediated mutagenesis; Genomic and chromosomal alterations; Challenges at the replication fork; Editing and repair; Decision points, repair or mutate; DNA polymerases and translesion synthesis; DNA structural challenges; and Targeted mutagenesis. The schedule also provides ample time for vibrant group discussions plus one-on-one and small group interactions. Daily poster sessions enable the presentation of additional work and facilitate direct interaction among students, postdoctoral fellows, new investigators, and more senior figures. Key objectives are to explore current knowledge at the frontier of mutagenesis research, with emphasis on molecular mechanisms and novel approaches to studying these mechanisms; to define therapeutic strategies to enhance the maintenance of genomic integrity and to take advantage of mutagenesis in the treatment of disease; to stimulate novel collaborations, especially exploiting work across experimental systems and disciplines; and to enhance and promote the careers of young scientists and encourage their continuation in the field. The new venue near Barcelona, Spain serves perfectly to further the Mutagenesis GRC tradition of alternating sites between Europe and the U.S. The site will provide full access and support to the conference, and is itself a significant attraction for potential attendees.

描述（由申请人提供）：