Mechanisms of Dendritic Spine Stability
树突棘稳定性的机制
基本信息
- 批准号:8585884
- 负责人:
- 金额:$ 37.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-12-04 至 2015-11-30
- 项目状态:已结题
- 来源:
- 关键词:ActinsAffectAutistic DisorderBindingBiochemicalBiological AssayBrainCalmodulinCell membraneCell-Free SystemCognition DisordersDendritesDendritic SpinesDiseaseEnzymesF-ActinFluorescence Recovery After PhotobleachingGlutamate ReceptorGoalsHealthHippocampus (Brain)ImageIndividualLifeLinkLocationLong-Term DepressionMaintenanceMediatingMembraneMicrofilamentsMolecularMood DisordersMorphologyNerveNeurodegenerative DisordersNeurologicNeuronsPathway interactionsPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsPhospholipidsPhosphoric Monoester HydrolasesPhosphorylationPhosphotransferasesPhysiologicalPlayPropertyProtein Kinase CProteinsRNA InterferenceRegulationRodentRoleSeriesShapesSignal TransductionSiteStrokeStructureSynapsesSynaptic plasticitySynaptophysinTestingTimeVertebral columnWorkcell fixingcofilincombatdensityfluorescence imagingmutantmyristoylated alanine-rich C kinase substrateneuropsychiatrynovelpolymerizationpostsynapticpresynapticresearch studyresponsesignal processingtherapy design
项目摘要
DESCRIPTION (provided by applicant): The long-term goal of this project is to identify molecular mechanisms that regulate the stability and plasticity of dendritic spines, small postsynaptic structures that play key roles in signal processing in neuronal circuits. Disruptions of spine numbers and shape occur in many neurological and neuropsychiatric diseases, including mood disorders, autism, and neurodegenerative disease. The size and shape of spines correlates with the physiological strength of the synapse, thus understanding the key molecular pathways that regulate spine shape and stability are crucial for designing therapies to combat such cognitive diseases. This project will focus on a central molecular pathway controlling spine shape and stability that involves the protein MARCKS. Using quantitative fluorescence imaging in dissociated cultures of rodent neurons, the project will characterize the function of MARCKS in dendritic spines using cellular and molecular approaches. Project objectives are to identify the interaction of MARCKS with downstream effectors and their influence on actin filaments and synaptic protein assemblies.
描述(由申请人提供):该项目的长期目标是确定调节树突棘稳定性和可塑性的分子机制,树突棘是在神经元回路中信号处理中起关键作用的小突触后结构。脊柱数量和形状的破坏发生在许多神经和神经精神疾病中,包括情绪障碍、自闭症和神经退行性疾病。棘突的大小和形状与突触的生理强度相关,因此了解调节棘突形状和稳定性的关键分子通路对于设计治疗方法以对抗此类认知疾病至关重要。该项目将集中在一个中央分子通路控制脊柱的形状和稳定性,涉及蛋白质MARCKS。利用定量荧光成像在啮齿动物神经元的解离培养,该项目将表征MARCKS的功能,在树突棘使用细胞和分子的方法。项目目标是确定MARCKS与下游效应物的相互作用及其对肌动蛋白丝和突触蛋白组装的影响。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tropomodulins are negative regulators of neurite outgrowth.
- DOI:10.1016/j.ejcb.2010.10.014
- 发表时间:2011-04
- 期刊:
- 影响因子:6.6
- 作者:Fath T;Fischer RS;Dehmelt L;Halpain S;Fowler VM
- 通讯作者:Fowler VM
Capping protein is essential for cell migration in vivo and for filopodial morphology and dynamics.
- DOI:10.1091/mbc.e13-12-0749
- 发表时间:2014-07-15
- 期刊:
- 影响因子:3.3
- 作者:Sinnar SA;Antoku S;Saffin JM;Cooper JA;Halpain S
- 通讯作者:Halpain S
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Shelley L Halpain其他文献
Shelley L Halpain的其他文献
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{{ truncateString('Shelley L Halpain', 18)}}的其他基金
High Content Screens of Neuronal Development for Autism Research
用于自闭症研究的神经元发育的高内涵屏幕
- 批准号:
7935500 - 财政年份:2009
- 资助金额:
$ 37.37万 - 项目类别:
ANALYSIS OF THE MICROTUBULE-ASSOCIATED PROTEOME DURING NEURONAL MORPHOGENESIS
神经元形态发生过程中微管相关蛋白质组的分析
- 批准号:
7723688 - 财政年份:2008
- 资助金额:
$ 37.37万 - 项目类别:
"Cell Biology of the Neuron" Gordon Conference
“神经元细胞生物学”戈登会议
- 批准号:
6760927 - 财政年份:2002
- 资助金额:
$ 37.37万 - 项目类别:
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