Innovations in Pediatric Pain Research

小儿疼痛研究的创新

• 批准号: 8634406
• 负责人: Tonya M Palermo
• 金额: $ 17.71万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8634406
• 关键词: Abdominal Pain; Achievement; Adolescent; Adult; Affect; Aftercare; Anesthesiology; Anxiety; Area; Award; Behavior Therapy; Caregivers; Child; Childhood; Clinical Research; Clinical Trials; Clinical Trials Design; Cognitive Therapy; Collaborations; Conduct Clinical Trials; Coping Skills; Data; Development; Distress; Economic Burden; Educational process of instructing; Emotional; Emotional Stress; Environment; Evaluation; Face; Faculty; Family; Fellowship; Fostering; Functional disorder; Funding; Goals; Grant; Health; Health Services; Health Services Accessibility; Individual; Internet; Intervention; Intervention Studies; Knowledge; Leadership; Measurable; Measurement; Medical center; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Musculoskeletal Pain; NCI Scholars Program; National Institute of Child Health and Human Development; Online Systems; Outcome; Pain; Pain Measurement; Pain Research; Pain management; Parenting behavior; Parents; Patient Education; Perioperative; Physical Function; Physical activity; Play; Postdoctoral Fellow; Problem Solving; Psychology; Psychophysics; Publications; Quality of life; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Activity; Research Personnel; Research Support; Research Training; Risk Factors; Role; Science; Services; Site; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Social Functioning; Social Impacts; Solutions; Stress; Symptoms; Testing; Time; Training; Training Programs; United States National Institutes of Health; Universities; Washington; Work; Writing; Youth; actigraphy; career; chronic pain; coping; cost; cost effective; diaries; disability; economic cost; economic impact; effective intervention; effective therapy; efficacy testing; evidence base; experience; flexibility; follow-up; improved; improved functioning; innovation; innovative technologies; medical specialties; modifiable risk; next generation; parental role; patient oriented; patient oriented research; post-doctoral training; programs; psychologic; public health relevance; skills; skills training; social; standard of care; therapy design; therapy development; tool; treatment effect; treatment response

PROJECT SUMMARY This is a competitive renewal of K24HD060068. An estimated 20% to 40% of otherwise healthy children and adolescents suffer from chronic pain such as abdominal and musculoskeletal pain. Many of these children also experience significant sleep disturbances. Chronic pain and associated symptoms (such as sleep problems) results in a measurable decline in children's quality of life and produces stress and economic burden on parents and families. Increasingly, cognitive-behavioral therapies (CBT) are emerging as effective interventions for pediatric chronic pain. Because children and families face challenges accessing specialty services such as CBT for chronic pain, innovative technologies may be a solution for broadening access to care. The candidate's research activities during the prior period of K24 support focused on three areas: sleep-wake disturbances, behavioral interventions, and assessment of physical activity and function. Significant progress and achievements were made during the prior period of support in publications, new grants awarded, mentorship of fellows and junior faculty, career advancement, and academic leadership. The primary objectives of this renewal application for a Midcareer Investigator Award in Patient-Oriented Research are for the candidate to fully develop and evaluate innovative, cost-effective psychological treatments to decrease pain and sleep disturbances, and improve functioning in children and adolescents with chronic pain; to expand research knowledge of psychophysical pain assessment; and to teach new clinicians the skills necessary for developing innovative research in pediatric pain and supporting them in their transition to research independence. Over the next period of K24 support, the candidate will complete studies funded with current research support including a NIH/NICHD R01 grant to evaluate the efficacy of an internet-delivered behavioral intervention for pediatric chronic pain and disability (Project 1); and a NIH/NICHD R21 grant to develop and test the efficacy of a parental problem solving intervention designed to reduce distress in parent caregivers of youth with chronic pain (Project 2). New research proposed during the award is focused on evaluating the feasibility and preliminary efficacy of CBT for insomnia in youth with chronic pain and sleep disturbances (Project 3). Career objectives in mentoring beginning clinician investigators are to provide training in conducting assessment and intervention research using innovative technologies, to provide direct experience and training in writing grants and obtaining independent research funding, and to foster a career-long commitment to patient-oriented research. Formal didactic programs are available through several university programs including T32 postdoctoral training, a NIH KL2 program, and a Clinical research mentored scholars program. The University of Washington provides an ideal environment with a strong record of interdisciplinary patient-oriented pain research and collaborative science.

项目摘要 这是K24HD060068的竞争更新。估计有20％至40％的健康儿童和 青少年患有慢性疼痛，例如腹部和肌肉骨骼疼痛。这些孩子也有许多 经历严重的睡眠障碍。慢性疼痛和相关症状（例如睡眠问题） 导致儿童生活质量的可衡量下降，并产生压力和经济负担 父母和家庭。越来越多的认知行为疗法（CBT）作为有效的干预措施出现 用于小儿慢性疼痛。因为儿童和家庭面临着获得专业服务的挑战，例如 CBT用于慢性疼痛，创新技术可能是扩大护理机会的解决方案。这 候选人的研究活动在K24的前期支持，重点是三个领域：睡眠效果 干扰，行为干预以及对体育活动和功能的评估。取得重大进展 并在上一期的出版物中取得了成就，授予了新的赠款， 研究员和初级教师，职业发展和学术领导力的指导。主要 此续签申请的目标申请中级护理研究员奖的患者研究奖是针对患者的研究 候选人充分发展和评估创新的，具有成本效益的心理治疗以减少 疼痛和睡眠障碍，并改善患有慢性疼痛的儿童和青少年的功能；扩展 心理物理疼痛评估的研究知识；并教新临床医生 在小儿疼痛方面发展创新的研究，并支持它们过渡到研究 独立。在下一阶段的K24支持中，候选人将完成资助的研究 研究支持，包括NIH/NICHD R01赠款，以评估互联网行为的功效 小儿慢性疼痛和残疾的干预（项目1）；以及NIH/NICHD R21赠款，以开发和 测试父母问题解决干预措施的疗效，旨在减少父母护理人员的困扰 慢性疼痛的青年（项目2）。奖励期间提出的新研究重点是评估 CBT对慢性疼痛和睡眠障碍青年失眠的可行性和初步疗效 （项目3）。指导初学者临床医生研究人员的职业目标将提供培训 使用创新技术进行评估和干预研究，以提供直接的经验 以及培训写作赠款和获得独立研究资金，并培养职业生涯 致力于以患者为导向的研究。正式的教学课程可通过几所大学获得 包括T32博士后培训，NIH KL2计划和临床研究指导学者在内的计划 程序。华盛顿大学提供了一个理想的环境，并具有跨学科的良好记录 面向患者的疼痛研究和协作科学。