43rd Annual Meeting of the American Aging Association

描述（由申请人提供）：我们正在申请资金，以支持2014年美国老龄化协会（年龄）第43届年会将在威斯汀酒店举行，圣安东尼奥，得克萨斯州5月30日至6月2日。近年来，该会议已发展成为人类学研究的主要会议之一。会议的主题是“减缓衰老：信号传导、抗应激、干细胞和小分子--新旧模型的见解”。“罗谢尔·布芬斯坦博士与老龄问题方案委员会（布朗-博格、纳尔逊、尼古拉-祖吉奇、奥多、蒂森鲍姆、汤普森博士）、会议主席和老龄问题执行委员会共同组织科学方案。其目的是汇集来自多个学科的科学家，创建一个论坛，介绍和批判性讨论老龄化研究的最新发现，并激发参与者之间的前瞻性思维和合作。请拨资金用于下列人员的旅费：1）应邀演讲者和2）有成就的年轻科学家（研究生、博士后研究员和年轻教员），他们可以 受益于接触该领域的领导者，展示他们的研究成果，并有机会为这个自由交流的论坛做出贡献。本次会议的具体目标是： 召集基础和临床科学家的广泛论坛，介绍有关减缓衰老机制的最新研究; B）确保覆盖各种公认的（例如，酵母、蠕虫、苍蝇，以及人和非人灵长类动物）和非传统的（例如，海龟、蜜蜂和鼹鼠）实验动物模型和最先进的技术; c）鼓励对老龄化的新旧概念范式进行公开讨论; d）强调综合和转化研究的机会;以及e）评估实验和生活方式 这些干预措施可能减缓人类衰老，并为潜在的治疗方法开发新的途径。受邀的演讲者包括老龄化领域的著名科学家以及因其科学和激发辩论的能力而被选中的其他学科。这次会议的一个关键目标是通过包括在老龄化研究内外的新星和科学家，他们不是“老龄化会议电路”的定期发言人：即，促进更广泛的参与，并提出新的想法，新颖的实验技术和有见地的方法，这个临床重要的，多学科的，综合性的领域。会议还将重点关注有助于维持稳态及其在缓慢衰老物种（如人类）中的调节的保护机制的趋同。主题包括-衰老中的昼夜节律失调：后果和原因;被遗忘的代谢，衰老中的小分子;抗应激和信号传导;肠道微生物组及其在免疫，炎症和衰老中的作用;保护蛋白和蛋白稳态;衰老过程中蛋白稳态功能障碍;永远年轻：组织再生和干细胞;延缓衰老：生活方式的改变和干预。将通过与会者调查评估本次会议在实现既定目标，特别是扩大发言者和议题范围方面的成效，并以此指导今后的会议。

DESCRIPTION (provided by applicant): We are requesting funds to support the 2014 American Aging Association (AGE) 43rd Annual Meeting to be held at the Westin Hotel, San Antonio, Texas on May 30th -June 2nd. In recent years, this meeting has grown to become one of the premier meetings for biogerontological research. The meeting theme is "Slowing Aging: Signaling, Stress Resistance, Stem Cells, and Small Molecules -- Insights from Old and New Models." Dr. Rochelle Buffenstein together with the AGE Program Committee (Drs. Brown-Borg, Nelson, Nikolich-Zugich, Oddo, Tissenbaum, Thompson), Session Chairs and the AGE Executive Board organize the scientific program. The objective is to bring together scientists from multiple disciplines to create a forum for presentation and critical discussion of the latest discoveries in aging research and to stimulate forward thinking and collaboration among participants. Funds are requested for travel expenses of 1) the invited speakers and 2) meritorious junior scientists (graduate students, post-doctoral fellows and junior faculty) who can benefit from exposure to the leaders of the field, present their research findings and have the opportunity to contribute to this forum of free exchange. The specific goals of this meeting are a) to assemble a broad-based forum of basic and clinical scientists to present the latest research on mechanisms involved in slowing aging; b) to ensure coverage of a variety of well-established (e.g., yeasts, worms, flies, and both human and non-human primates) and non- traditional (e.g., turtles, bees and mole-rats) experimental animal models and state-of-the-art technologies; c) to encourage open discussion of new and old conceptual paradigms in aging; d) to emphasize integrative and translational research opportunities; and e) to evaluate experimental and lifestyle interventions that may slow human aging and develop novel avenues for potential therapeutics. The invited speakers include renowned scientists in aging as well as other disciplines selected for their science and ability to stimulate debate. A key goal of this meeting is met by inclusion o rising stars and scientists both in and outside aging research who are not regular speakers on the "aging conference circuit: namely, to promote broader participation and present fresh ideas, novel experimental technologies and insightful approaches to this clinically important, multidisciplinary, and integrative field. The meeting will also focus on the convergence of protective mechanisms that contribute to the maintenance of homeostasis and its modulation in slow aging species, such as humans. Topics include- Circadian Dysregulation in Aging: Consequences, and Causes; Forgotten Metabolites, Small Molecules in Aging; Stress Resistance and Signaling; The Gut Microbiome and its Role in Immunity, Inflammation and Aging; Protective Proteins and Proteostasis; Proteostatic Dysfunction During Aging; Forever Young: Tissue Regeneration and Stem Cells; and Retarding Aging: Lifestyle Changes and Interventions. The effectiveness of this meeting in achieving its stated goals, particularly broadening the range of speakers and topics, will be evaluated by participant survey and used to guide future meetings.