43rd Annual Meeting of the American Aging Association

描述(由申请者提供)：我们正在申请资金，以支持将于5月30日至6月2日在德克萨斯州圣安东尼奥威斯汀酒店举行的2014年美国老龄协会(AGE)第43届年会。近年来，这个会议已经发展成为生物老年学研究的主要会议之一。这次会议的主题是“延缓衰老：信号、抗应激、干细胞和小分子--来自新旧模型的见解”。Rochelle Buffenstein博士与AGE计划委员会(Brown-Borg、Nelson、Nikolich-Zugich、Oddo、Tissenbaum、Thompson博士)、会议主席和AGE执行委员会共同组织了这项科学计划。其目的是将来自多个学科的科学家聚集在一起，创建一个论坛，介绍和批判性地讨论老龄化研究的最新发现，并鼓励参与者之间的前瞻性思维和合作。1)被邀请的演讲者和2)有功绩的初级科学家(研究生、博士后研究员和初级教员)的旅费。 受益于与该领域的领导者接触，展示他们的研究成果，并有机会为这个自由交流论坛做出贡献。这次会议的具体目标是a) 召集基础和临床科学家的广泛论坛，介绍关于延缓衰老的机制的最新研究；b)确保涵盖各种成熟的(例如酵母、蠕虫、苍蝇、人类和非人类灵长类动物)和非传统的(例如海龟、蜜蜂和鼹鼠)实验动物模型和最新技术；c)鼓励就衰老的新旧概念范式进行公开讨论；d)强调综合和翻译研究机会；以及e)评估实验和生活方式 可能延缓人类衰老并为潜在疗法开发新途径的干预措施。受邀的演讲者包括老龄化领域的知名科学家以及其他因其科学和激发辩论能力而被选中的学科。本次会议的一个关键目标是将老龄化研究内外的后起之秀和科学家纳入其中，他们不是“老龄化会议巡回演讲者”的定期演讲者：即促进更广泛的参与，并在这个具有临床重要性的、多学科和综合的领域提出新的想法、新颖的实验技术和有洞察力的方法。会议还将集中讨论有助于维持动态平衡的保护机制的趋同及其在诸如人类等缓慢衰老物种中的调节。主题包括：衰老中的昼夜节律失调：后果和原因；被遗忘的代谢物，衰老中的小分子；应激抵抗和信号；肠道微生物组及其在免疫、炎症和衰老中的作用；保护蛋白质和蛋白质稳定；衰老过程中的前列腺功能障碍；永远年轻：组织再生和干细胞；以及延缓衰老：生活方式的改变和干预。本次会议在实现既定目标方面的成效，特别是扩大发言者和议题的范围，将通过参与者调查进行评估，并用来指导今后的会议。

DESCRIPTION (provided by applicant): We are requesting funds to support the 2014 American Aging Association (AGE) 43rd Annual Meeting to be held at the Westin Hotel, San Antonio, Texas on May 30th -June 2nd. In recent years, this meeting has grown to become one of the premier meetings for biogerontological research. The meeting theme is "Slowing Aging: Signaling, Stress Resistance, Stem Cells, and Small Molecules -- Insights from Old and New Models." Dr. Rochelle Buffenstein together with the AGE Program Committee (Drs. Brown-Borg, Nelson, Nikolich-Zugich, Oddo, Tissenbaum, Thompson), Session Chairs and the AGE Executive Board organize the scientific program. The objective is to bring together scientists from multiple disciplines to create a forum for presentation and critical discussion of the latest discoveries in aging research and to stimulate forward thinking and collaboration among participants. Funds are requested for travel expenses of 1) the invited speakers and 2) meritorious junior scientists (graduate students, post-doctoral fellows and junior faculty) who can benefit from exposure to the leaders of the field, present their research findings and have the opportunity to contribute to this forum of free exchange. The specific goals of this meeting are a) to assemble a broad-based forum of basic and clinical scientists to present the latest research on mechanisms involved in slowing aging; b) to ensure coverage of a variety of well-established (e.g., yeasts, worms, flies, and both human and non-human primates) and non- traditional (e.g., turtles, bees and mole-rats) experimental animal models and state-of-the-art technologies; c) to encourage open discussion of new and old conceptual paradigms in aging; d) to emphasize integrative and translational research opportunities; and e) to evaluate experimental and lifestyle interventions that may slow human aging and develop novel avenues for potential therapeutics. The invited speakers include renowned scientists in aging as well as other disciplines selected for their science and ability to stimulate debate. A key goal of this meeting is met by inclusion o rising stars and scientists both in and outside aging research who are not regular speakers on the "aging conference circuit: namely, to promote broader participation and present fresh ideas, novel experimental technologies and insightful approaches to this clinically important, multidisciplinary, and integrative field. The meeting will also focus on the convergence of protective mechanisms that contribute to the maintenance of homeostasis and its modulation in slow aging species, such as humans. Topics include- Circadian Dysregulation in Aging: Consequences, and Causes; Forgotten Metabolites, Small Molecules in Aging; Stress Resistance and Signaling; The Gut Microbiome and its Role in Immunity, Inflammation and Aging; Protective Proteins and Proteostasis; Proteostatic Dysfunction During Aging; Forever Young: Tissue Regeneration and Stem Cells; and Retarding Aging: Lifestyle Changes and Interventions. The effectiveness of this meeting in achieving its stated goals, particularly broadening the range of speakers and topics, will be evaluated by participant survey and used to guide future meetings.