The role of beta-catenin in cyst initiation in Autosomal Dominant Polycystic Kidn
β-连环蛋白在常染色体显性多囊肾囊肿发生中的作用
基本信息
- 批准号:8683329
- 负责人:
- 金额:$ 38.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-28 至 2018-04-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAffectAutosomal Dominant Polycystic KidneyBiochemicalBiological ProcessCell LineCellsClonal ExpansionComplexCyclic AMPCystCystic kidneyDialysis procedureDiseaseE-CadherinEnd stage renal failureEnzymesEpithelialEpithelial CellsEpitheliumEventFailureFamily memberGene TargetingGoalsGraft RejectionGrantHealth Care CostsHereditary DiseaseHigh PrevalenceHumanIndividualKidneyKidney DiseasesKidney TransplantationLaboratoriesMagnetic Resonance ImagingMediatingModelingModificationMolecularMutationOrgan Culture TechniquesPathogenesisPathway interactionsPolycystic Kidney DiseasesPost-Translational Protein ProcessingProcessProprotein Convertase 1Public HealthQuality of lifeReceptor Protein-Tyrosine KinasesRenal dialysisRenal functionResearchRoleSignal PathwaySignal TransductionStem cellsStructureTestingTherapeuticTherapeutic InterventionTransplantationTreatment CostTubular formationUltrasonographyUnited StatesWorkbasebeta catenincostdrug discoveryfrontierhuman diseaseimpaired productivityinhibitor/antagonistkidney epithelial cellmeetingspreventprogramspublic health relevancetherapeutic targettranscription factortumor
项目摘要
DESCRIPTION (provided by applicant): Autosomal Dominant Polycystic kidney disease (ADPKD) is characterized by numerous cysts within the kidneys of afflicted individuals. The cysts formed in ADPKD can greatly enlarge the kidneys while replacing the normal kidney structures, resulting in reduced kidney function and progression to end-stage renal disease that can only be treated by lifelong dialysis or kidney transplants. As a disease that affects 1 in 800~1000 individuals, ADPKD is among the most common genetic disorders. In the United States, there are 600,000 individuals, and worldwide 12.5 million, with PKD [1]. Thus, ADPKD represents a major public health issue, and accounts for hundreds of millions (and perhaps over a billion) of dollars in health care costs, particularly for dialysis treatments and the cost of drgs that prevent transplant rejections, as well as the cost involved of decreased productivity and impaired quality of life of individuals with ADPKD. For all these reasons, it is of great importanc to discover treatments that directly affect the molecular causes of ADPKD, and that will prevent the progression to end- stage renal disease and dialysis or transplantation. Over the past 5 years the Kreidberg laboratory has investigated the role of receptor tyrosine kinase and Wnt signaling in the pathogenesis of ADPKD. Dr. Kreidberg's laboratory has found that Wnt signaling and beta-catenin expression is highly elevated in cyst lining cells in ADPKD. In this grant they propose to extend their studies to understand how b-catenin integrates signals from many pathways to cause the initiation of cyst formation in individuals with ADPKD. By understanding the processes involved in the initiation of cysts, we may identify therapeutic targets that inhibit the initiation or early progression of cysts, before they are clinically detectable.
描述(由申请人提供):常染色体显性多囊肾病(ADPKD)的特征是患病个体的肾脏内存在大量囊肿。ADPKD中形成的囊肿可以大大扩大肾脏,同时取代正常的肾脏结构,导致肾功能降低并进展为终末期肾病,只能通过终身透析或肾移植治疗。ADPKD是最常见的遗传性疾病之一,发病率为1/800~1000。在美国,有60万人,全世界有1250万人患有PKD [1]。因此,ADPKD代表了一个主要的公共卫生问题,并占数亿美元(可能超过十亿美元)的医疗保健费用,特别是透析治疗和预防移植排斥的药物的费用,以及生产力下降和ADPKD患者生活质量受损所涉及的费用。由于所有这些原因,发现直接影响ADPKD分子病因的治疗方法,并防止进展为终末期肾病和透析或移植是非常重要的。在过去的5年中,Kreidberg实验室研究了受体酪氨酸激酶和Wnt信号在ADPKD发病机制中的作用。Kreidberg博士的实验室发现,Wnt信号和β-连环蛋白表达在ADPKD的囊肿衬里细胞中高度升高。在这项研究中,他们建议扩展他们的研究,以了解b-连环蛋白如何整合来自许多途径的信号,从而导致ADPKD患者囊肿形成的开始。通过了解囊肿发生的过程,我们可以在临床检测到囊肿之前确定抑制囊肿发生或早期进展的治疗靶点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jordan A Kreidberg其他文献
KIDNEY AND LUNG ABNORMALITIES IN α-3 INTEGRIN DEFICIENT MICE. † 338
α-3 整合素缺陷小鼠的肾脏和肺部异常。†338
- DOI:
10.1203/00006450-199604001-00358 - 发表时间:
1996-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Stuart L Goldstein;Michael J Donovan;Jordan A Kreidberg - 通讯作者:
Jordan A Kreidberg
Jordan A Kreidberg的其他文献
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{{ truncateString('Jordan A Kreidberg', 18)}}的其他基金
Transcriptional Reprogramming in Podocyte Injury
足细胞损伤中的转录重编程
- 批准号:
9149798 - 财政年份:2016
- 资助金额:
$ 38.06万 - 项目类别:
The role of beta-catenin in cyst initiation in Autosomal Dominant Polycystic Kidn
β-连环蛋白在常染色体显性多囊肾囊肿发生中的作用
- 批准号:
9064636 - 财政年份:2014
- 资助金额:
$ 38.06万 - 项目类别:
Misregulation of receptor tyrosine kinase signaling in PKD
PKD 中受体酪氨酸激酶信号传导的失调
- 批准号:
8338906 - 财政年份:2011
- 资助金额:
$ 38.06万 - 项目类别:
Misregulation of receptor tyrosine kinase signaling in PKD
PKD 中受体酪氨酸激酶信号传导的失调
- 批准号:
8726973 - 财政年份:2011
- 资助金额:
$ 38.06万 - 项目类别:
Misregulation of receptor tyrosine kinase signaling in PKD
PKD 中受体酪氨酸激酶信号传导的失调
- 批准号:
8541009 - 财政年份:2011
- 资助金额:
$ 38.06万 - 项目类别:
Misregulation of receptor tyrosine kinase signaling in PKD
PKD 中受体酪氨酸激酶信号传导的失调
- 批准号:
8238482 - 财政年份:2011
- 资助金额:
$ 38.06万 - 项目类别:
BMP and FGF Signaling in kidney progenitor cells
肾祖细胞中的 BMP 和 FGF 信号转导
- 批准号:
8494042 - 财政年份:2010
- 资助金额:
$ 38.06万 - 项目类别:
BMP and FGF Signaling in kidney progenitor cells
肾祖细胞中的 BMP 和 FGF 信号转导
- 批准号:
8318882 - 财政年份:2010
- 资助金额:
$ 38.06万 - 项目类别:
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