Clinical Services Core

临床服务核心

• 批准号: 8641303
• 负责人: BENIGNO RODRIGUEZ
• 金额: $ 18.49万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8641303
• 关键词: Acquired Immunodeficiency Syndrome; American; Area; Biometry; Clinical; Clinical Management; Clinical Services; Clinical Trials; Collaborations; Data; Data Set; Databases; Development; Epidemiology; HIV; HIV vaccine; Human Subject Research; Institution; Laboratories; Link; Mining; Patient Care; Patients; Play; Process; Quality Control; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Role; Sampling; Services; Specimen; Study Subject; Support System; System; Teacher Professional Development; cohort; data structure; design; interest; member; microbicide; repository; research study; tool; vaccine development; volunteer

The Clinical Services Core (CSC) is a central resource designed to support each step in the development, conduct, and analysis of all human subject research projects originated from or supported by the Case CFAR. Specific aims of the CSC include: ¿ Maintain and expand a comprehensive and accessible Patient Care and Research Database (PCRD). ¿ Maintain and expand a specimen repository linked to the patient care database. ¿ Provide researchers with access to patients pre-selected for interest and identified as eligible (through mining of the Patient Care and Research Database) to participate in HIV clinical trials or other research studies. ¿ Maintain, expand, and provide access to a newly established database of over 800 HIV-negative volunteers in the Cleveland area who are interested in participating in HIV research. ¿ Coordinate the exchange of clinical and laboratory data with other institutions participating in collaborative projects designed to conduct research on HIV observational data. The Case CFAR is a founding member of two such collaborations, the CFAR Network of Integrated Clinical Systems (CNICS) and the North American AIDS Cohort Collaboration on Research and Design (NAACCORD). ¿ Assist CFAR researchers in planning and designing studies that use the PCRD and the specimen repository by helping investigators formulate research questions that take full advantage of the data and specimens available through the Core. ¿ Provide biostatistical and epidemiologic support and advice to Case CFAR investigators, and provide training and faculty development in epidemiology and biostatistics.

临床服务核心 (CSC) 是一个中央资源，旨在支持源自案例 CFAR 或由案例 CFAR 支持的所有人类受试者研究项目的开发、实施和分析的每一步。 CSC 的具体目标包括： ¿ 维护和扩展全面且可访问的患者护理和研究数据库 (PCRD)。 ¿ 维护和扩展与患者护理数据库链接的样本存储库。 ¿ 为研究人员提供访问预先选择感兴趣的患者并确定有资格（通过挖掘患者护理和研究数据库）参与艾滋病毒临床试验或其他研究的患者。 ¿ 维护、扩展并提供对新建立的数据库的访问，该数据库包含克利夫兰地区 800 多名有兴趣参与艾滋病毒研究的艾滋病毒阴性志愿者。 ¿ 与参与旨在开展艾滋病毒观察数据研究的合作项目的其他机构协调临床和实验室数据的交换。 Case CFAR 是两个此类合作组织的创始成员，即 CFAR 综合临床系统网络 (CNICS) 和北美艾滋病队列研究与设计合作组织 (NAACCORD)。 ¿ 通过帮助研究人员制定充分利用核心提供的数据和样本的研究问题，协助 CFAR 研究人员规划和设计使用 PCRD 和样本存储库的研究。 ¿ 为案例CFAR 调查人员提供生物统计学和流行病学支持和建议，并提供流行病学和生物统计学方面的培训和教师发展。