Clinical Services Core D

项目摘要核心D-临床核心 临床服务核心(CSC)是一项核心资源，旨在支持 开发、实施和分析所有源于或支持的人类主题研究项目 CFAR一案。CSC的具体目标包括： 维护和扩展一个全面的、可访问的患者护理和研究数据库。 维护并扩展链接到患者护理数据库的标本存储库。 为研究人员提供访问预先选择的感兴趣的患者并确定为合格患者的途径(通过 挖掘患者护理和研究数据库)参与HIV临床试验或其他 研究性研究。 维护、扩展并提供对新建立的800多名艾滋病毒阴性者的数据库的访问 克利夫兰地区有兴趣参与艾滋病毒研究的志愿者。 协调与参与的其他机构交换临床和实验室数据 旨在对艾滋病毒观测数据进行研究的合作项目。CFAR案例是一个 两个这样的合作的创始成员，CFAR综合临床系统网络 (CNICs)和北美艾滋病队列研究和设计合作(NA- 协议)。 协助研究人员规划和设计使用PCRD和标本的研究 通过帮助调查人员制定充分利用数据的研究问题来存储信息库 以及可通过核心获取的样本。 为CFAR案件调查人员提供生物统计和流行病学支持和建议，并提供 流行病学和生物统计学方面的培训和师资发展。

Project Summary Core D – Clinical Core The Clinical Services Core (CSC) is a central resource designed to support each step in the development, conduct, and analysis of all human subject research projects originated from or supported by the Case CFAR. Specific aims of the CSC include:  Maintain and expand a comprehensive and accessible Patient Care and Research Database (PCRD).  Maintain and expand a specimen repository linked to the patient care database.  Provide researchers with access to patients pre-selected for interest and identified as eligible (through mining of the Patient Care and Research Database) to participate in HIV clinical trials or other research studies.  Maintain, expand, and provide access to a newly established database of over 800 HIV-negative volunteers in the Cleveland area who are interested in participating in HIV research.  Coordinate the exchange of clinical and laboratory data with other institutions participating in collaborative projects designed to conduct research on HIV observational data. The Case CFAR is a founding member of two such collaborations, the CFAR Network of Integrated Clinical Systems (CNICS) and the North American AIDS Cohort Collaboration on Research and Design (NA- ACCORD).  Assist CFAR researchers in planning and designing studies that use the PCRD and the specimen repository by helping investigators formulate research questions that take full advantage of the data and specimens available through the Core.  Provide biostatistical and epidemiologic support and advice to Case CFAR investigators, and provide training and faculty development in epidemiology and biostatistics.