Interactions between RAGE and the type 1 angiotensin receptor determine the pro-atherosclerotic actions of angiotensin II

RAGE 和 1 型血管紧张素受体之间的相互作用决定了血管紧张素 II 的促动脉粥样硬化作用

• 批准号: nhmrc : 1081013
• 负责人: A/Pr Kevin Pfleger
• 金额: $ 34.8万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interactions-rage-type-angiotensin-ii/518782
• 关键词: Interactions; between; RAGE; type; angiotensin

Heart attacks and strokes are a major cause of death and disability in Australians. Activation of the renin angiotensin system plays a key role in the development and progression of atherosclerosis, the process that leads to narrowing and obstruction of arteries. In preliminary data we have found a way to block these pathways without affecting the control of blood pressure. We believe that interventions based on these data will be important for the prevention and treatment of heart disease.

心脏病发作和中风是澳大利亚人死亡和残疾的主要原因。肾素血管紧张素系统的激活在动脉粥样硬化的发展和进展中起关键作用，动脉粥样硬化是导致动脉狭窄和阻塞的过程。在初步的数据中，我们已经找到了一种方法来阻断这些通路，而不影响血压的控制。我们相信，基于这些数据的干预措施对于预防和治疗心脏病将非常重要。