Development of resonance energy transfer technologies to detect GPCR heterodimer complexes in living cells

开发共振能量转移技术来检测活细胞中的 GPCR 异二聚体复合物

• 批准号: nhmrc : 513780
• 负责人: A/Pr Kevin Pfleger
• 金额: $ 13.71万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-resonance-energy-living-cells/76608
• 关键词: Development; resonance; energy; transfer; technologies

G-protein coupled receptors are proteins at the surface of most cells in the body. They bind to drugs, transmitting signals into cells that change what cells are doing. Recent research indicates that different types of these proteins can interact with each other and when one of these protein combinations binds a drug, it acts differently to when the proteins act separately. The aim of our project is to find out which protein combinations exist and to find drugs that bind to them specifically.

G蛋白偶联受体是体内大多数细胞表面的蛋白质。它们与药物结合，将信号传输到细胞中，改变细胞的行为。最近的研究表明，不同类型的这些蛋白质可以相互作用，当其中一种蛋白质组合与药物结合时，它的作用与蛋白质单独作用时不同。我们项目的目的是找出存在哪些蛋白质组合，并找到与它们特定结合的药物。