The Epidemiology of Human Chondrogenic Progenitor Cells

人类软骨祖细胞的流行病学

基本信息

  • 批准号:
    8735064
  • 负责人:
  • 金额:
    $ 63.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-09-16 至 2017-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This program seeks to advance the field of Cartilage Tissue Engineering by defining strategies and principles for selecting and optimizing available sources of chondrogenic connective tissue progenitors (CTP- Cs). It will also provide the tissue engineering community with a rigorous and standardized quantitative methodology for objective evaluation and comparison of cell sourcing and processing options. Successful repair or regeneration of cartilage tissue requires a source of CTP-Cs, i.e. native cells that are capable of chondrogenic differentiation. Cartilage repair strategies must rely on one of several cell sourcing strategies. CTPs with chondrogenic potential reside in cartilage, as well as bone marrow, periosteum, muscle, fat and other tissues. Several of these tissue sources have already been or are being exploited to provide cells for cartilage repair and regeneration procedures. Although articular cartilage tissue shows little intrinsic capacity to repair, some cells in both normal and diseased cartilage tissue can be induced to proliferate and differentiate to express a chondrocytic phenotype in vitro. Such cartilage-derived CTP-Cs have become central to several treatment strategies based on transplantation of freshly isolated cartilage tissue or culture-expanded cells into a cartilage defect. To date, cell sourcing decisions and cell processing or fabrication strategies have generally not been based on quantitative assays of the concentration, prevalence or biological potential of the available cell sources. This program addresses three opportunities to improve clinical practices: 1) Define the concentration, prevalence and biological potential of chondrogenic connective tissue progenitors (CTP-Cs) in and around the adult human knee (articular cartilage, fat pad, synovium, periosteum, subchondral bone and marrow). 2) Define the relationship between cartilage tissue health and the concentration, prevalence and biological potential of CTP- Cs in human cartilage. 3) Test the hypothesis that differences in in vitro performance between CTP-C sources predict differences in in vivo performance.
描述(由申请人提供):该项目旨在通过定义选择和优化软骨结缔组织祖细胞(CTP- Cs)可用来源的策略和原则来推进软骨组织工程领域。它还将为组织工程界提供严格和标准化的定量方法,以客观评估和比较细胞来源和处理方案。软骨组织的成功修复或再生需要CTP-Cs的来源,即能够

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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George F Muschler其他文献

George F Muschler的其他文献

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{{ truncateString('George F Muschler', 18)}}的其他基金

Understanding and Using Variation in Source Materials for MSC Fabrication
了解和使用 MSC 制造的原材料变化
  • 批准号:
    10165695
  • 财政年份:
    2019
  • 资助金额:
    $ 63.21万
  • 项目类别:
Understanding and Using Variation in Source Materials for MSC Fabrication
了解和使用 MSC 制造的原材料变化
  • 批准号:
    10391356
  • 财政年份:
    2019
  • 资助金额:
    $ 63.21万
  • 项目类别:
Understanding and Using Variation in Source Materials for MSC Fabrication
了解和使用 MSC 制造的原材料变化
  • 批准号:
    10614506
  • 财政年份:
    2019
  • 资助金额:
    $ 63.21万
  • 项目类别:
Early Identification and Characterization of Connective Tissue Progenitors
结缔组织祖细胞的早期识别和表征
  • 批准号:
    8806193
  • 财政年份:
    2014
  • 资助金额:
    $ 63.21万
  • 项目类别:
The Epidemiology of Human Chondrogenic Progenitor Cells
人类软骨祖细胞的流行病学
  • 批准号:
    8577915
  • 财政年份:
    2013
  • 资助金额:
    $ 63.21万
  • 项目类别:
The Epidemiology of Human Chondrogenic Progenitor Cells
人类软骨祖细胞的流行病学
  • 批准号:
    9119486
  • 财政年份:
    2013
  • 资助金额:
    $ 63.21万
  • 项目类别:
The Epidemiology of Human Chondrogenic Progenitor Cells
人类软骨祖细胞的流行病学
  • 批准号:
    8925674
  • 财政年份:
    2013
  • 资助金额:
    $ 63.21万
  • 项目类别:
Extended Learning Curriculum for the Cleveland Clinic Orthopaedic & Rheumatology
克利夫兰诊所骨科扩展学习课程
  • 批准号:
    7751512
  • 财政年份:
    2009
  • 资助金额:
    $ 63.21万
  • 项目类别:
Cleveland Clinic Orthopaedic and Rheumatology Care -- Quality Innovation Summit 2
克利夫兰诊所骨科和风湿科护理——质量创新峰会2
  • 批准号:
    7674443
  • 财政年份:
    2009
  • 资助金额:
    $ 63.21万
  • 项目类别:
Optimizing Assays of Human Stem Cells in Bone Marrow
优化人类骨髓干细胞的检测
  • 批准号:
    7094092
  • 财政年份:
    2004
  • 资助金额:
    $ 63.21万
  • 项目类别:

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