Intellectual and Developmental Disabilities Research Centers 2013

 描述(由申请人提供)：本修订申请继续支持肯尼迪·克里格研究所和约翰·霍普金斯大学的智力和发育障碍研究中心(IDDRC)，是对RFA-HD-14-012的回应。IDDRC将继续支持一个大型、多样化和多学科的研究计划，重点是转化性研究，作为世界上一流的教育、临床和生物医学研究机构之一内专注于发展性残疾的研究的纽带。IDDRC将包括六个核心。行政核心(A)将为中心提供领导、管理和组织支持；协调教育方案组成部分(讲座和研讨会)；代表中心与研究所和大学行政部门互动；并作为NICHD的同事、其他IDDRCs和更广泛社区的接口。临床翻译核心(B)将在与参与者招募、IRB相关的活动中为中心调查人员提供支持 整个翻译过程中的活动、生物统计和移动发现。遗传学核心(C)将提供集中式组织培养，并在细胞遗传学、专门的分子遗传学、微阵列和测序研究以及生物信息学方面提供协助。翻译神经科学核心(D)将提供组织学和临床前成像设施，以及一组针对与发育障碍相关的代谢物和分子的高度专业化的分析。神经成像核心(E)将为研究人员提供从功能、体积、扩散张量和光谱磁共振成像以及使用TMS方法的研究中获得的数据的获取和定量分析方面的协助。最后，行为科学核心(F)将为参与者提供培训，以便与研究方案合作，选择神经心理学/认知评估的方法，设计功能磁共振成像的激活范例，以及评估运动功能的专门方法。明年将向69个项目提供核心支持，相当于每年超过3400万美元的联邦资金，外加一个由该中心直接资助的研究部分。

 DESCRIPTION (provided by applicant): This revised application for continued support of the Intellectual and Developmental Disabilities Research Center (IDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-HD-14-012. The IDDRC will continue supporting a large, diverse, and multidisciplinary program of research focused on developmental disorders with an emphasis on translational research, serving as the nexus for research focused on developmental disabilities within one of the premiere educational, clinical, and biomedical research institutions in the world. The IDDRC will include six Cores. An Administrative Core (A) will provide leadership, management, and organizational support for the Center; coordinate educational program components (lectures and seminars); represent the Center in interactions with Institute and University administration; and serve as the interface wit colleagues at NICHD, other IDDRCs, and the broader community. A Clinical Translational Core (B) will support Center investigators in activities related to participant recruitment, IRB-related activities, biostatistics, and moving findings along the entire translational pathway. A Genetics Core (C) will provide centralized tissue culture and assistance with cytogenetics, specialized molecular genetics, microarray and sequencing studies, and bioinformatics. A Translational Neuroscience Core (D) will provide histology and preclinical imaging facilities, as well as a group of highly specialized assays that target metabolites and molecules of relevance to developmental disorders. A Neuroimaging Core (E) will provide Investigators with assistance in acquisition and quantitative analysis of data derived from functional, volumetric, diffusion tensor and spectroscopic MR imaging, as well as for studies employing TMS methods. Finally, a Behavior Science Core (F) will offer training of participants for cooperation with research protocols, selection of methods for neuropsychological/cognitive assessment, design of activation paradigms for fMRI, and specialized methods for assessment of motor functioning. Core support this coming year will be provided to 69 projects representing annual federal funding of over $34 million, plus a Research Component funded directly by the Center.