Neural Mechanisms of Affective Salience in Aging

衰老过程中情感显着性的神经机制

• 批准号: 8898286
• 负责人: Lisa Feldman Barrett
• 金额: $ 9.81万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8898286
• 关键词: Adult; Affect; Affective; Age; Aging; Alzheimer' s disease risk; Amygdaloid structure; Anatomy; Arousal; Attention; Behavior; Behavioral; Brain; Brain region; Cognitive; Complex; Cues; Decision Making; Dementia; Environment; Event; Familiarity; Goals; Grant; Health; Hippocampus (Brain); Human; Image; Individual; Individual Differences; Insula of Reil; Link; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Memory; Memory impairment; Mental Health; Outcome; Persons; Process; Research; Resolution; Risk; Sampling; Scanning; Sensory; Social Functioning; Social Network; Social isolation; Stimulus; Structure; Surface; Symptoms; Thick; Time; Work; age related; aging brain; aging population; base; experience; insight; long term memory; longitudinal design; neuromechanism; normal aging; novel; physical conditioning; psychologic; relating to nervous system; response; sensory cortex; social

DESCRIPTION (provided by applicant): Successful aging appears to relate in part to a variety of behaviors that require processing of motivated, goal- directed, and personally relevant (i.e., salient) information. For the most part, current research on salience has focused on the cognitive factors that allow attention to relevant information in the external environment. In our research, we focus on age-related changes in "affective salience" and their implications for social functioning. In our original grant, we examined age-related changes in the processing of novel and affectively potent stimuli, with a focus on the human amygdala [(R01 AG030311), Neural Mechanisms of Social Decision Making in Aging, August 1, 2006 - July 31, 2011)]. We found that amygdala responses to novelty, valence, and arousal are less robust and the functional connectivity between the amygdala and other affective brain structures is reduced in older individuals than in younger people. These findings indicate that information in the world is less affectively salient to older individuals. This is despite the fact that there appear to be few anatomical changes in the network that we have identified underlying affective salience (other than normal age-related reductions in amygdala volume). In the competing renewal, we will expand on these findings anatomically, functionally, and behaviorally. Using high resolution scanning, we will examine with more sophistication and precision, and in a larger sample, the extent to which both the structural integrity and intrinsic connectivity of brain regions within th affective salience network are maintained (or change) with age (Aim 1). In the context of spared anatomy and intrinsic connectivity within the affective salience network, task- related affective assemblies within this network are less robust with age, and we will examine the extent to which age-related reductions in sensory information from the body (in the form of reduced interceptive sensitivity) are responsible for task-related reductions in affective salience (Aim 2). Perhaps objects and events in the world are less salient because the bodily perturbations they produce are not detected and represented as efficiently in the aging brain. Furthermore, we will examine the extent to which these reductions in affective salience and interception underlie or contribute to normal age-related changes in memory for novel, neutral material (Aim 3) and in social engagement (Aim 4). Finally, using a longitudinal design, we will confirm that any age-related stability or decrements in affective salience can be disentangled from the substantial individual differences that exist, and also examine the extent to which strong affective reactivity is a protective factor, resulting in better memory for novel material and/or maintained social engagement as people age (Aim 5).

描述(由申请人提供)：成功的衰老似乎部分与各种行为有关，这些行为需要处理动机、目标导向和个人相关(即，显著的)信息。在很大程度上，当前关于显著的研究集中在允许注意外部环境中的相关信息的认知因素上。在我们的研究中，我们关注与年龄相关的“情感显著”的变化及其对社会功能的影响。在我们最初的资助中，我们研究了新的和有效的刺激处理过程中与年龄相关的变化，重点是人类杏仁核[(R01 AG030311)，老龄化中的社会决策的神经机制，2006年8月1日-2011年7月31日]。我们发现，与年轻人相比，老年人的杏仁核对新颖性、效价和唤醒的反应不那么强烈，杏仁核和其他情感大脑结构之间的功能连接减少。这些发现表明，世界上的信息对年长的人来说不那么明显。这是尽管事实是，似乎很少有 我们已经确定潜在的情感突显的网络的解剖学变化(除了正常的年龄相关的杏仁核体积的减少)。在竞争更新中，我们将从解剖、功能和行为上扩展这些发现。使用高分辨率扫描，我们将以更复杂和更精确的方式，在更大的样本中，检查情感显著网络内大脑区域的结构完整性和内在连接性随年龄的保持(或改变)的程度(目标1)。在保留的解剖学和情感显著网络内的内在连接性的背景下，这个网络中与任务相关的情感集合随着年龄的增长而变得不那么健壮，我们将研究来自身体的感觉信息与年龄相关的减少(以降低拦截敏感度的形式)在多大程度上导致与任务相关的情感显著减少(目标2)。也许世界上的物体和事件不那么突出，因为它们产生的身体扰动没有被检测到，并在老化的大脑中有效地表现出来。此外，我们将研究这些情感突显和截获的减少在多大程度上是新的中性材料的记忆(目标3)和社会参与(目标4)的正常年龄相关记忆变化的基础或贡献。最后，使用纵向设计，我们将证实任何与年龄相关的情感显著的稳定或降低可以从存在的实质性个体差异中分离出来，并检查强烈的情感反应性是一个保护因素的程度，导致对新材料的更好记忆和/或随着人们年龄的增长保持社交参与(目标5)。