Body-oriented Therapy for Womens Substance Use Disorder Treatment

描述（由申请人提供）：本研究的长期目标是改善妇女的物质使用障碍（SUD）治疗。近期项目的目标是测试一种创新的身心干预措施的有效性，即以身体为导向的治疗中的正念意识（MABT），以减少SUD治疗中妇女的药物使用复发。MABT是一种新颖的身心方法，将动手（手动）方法与内感受训练和正念的身心心理教育方法相结合，以发展基于躯体的自我护理技能并促进情绪调节。一项使用重复测量的三组随机临床试验，该项目将招募225名妇女并随机分配到三组之一，MABT +常规治疗（TAU）（n=75），仅TAU（n=75）和妇女健康教育（WHE）+ TAU（控制时间和注意力）（n=75）。将在基线、干预后以及6个月和12个月随访时比较研究条件。主要目的是检验以下假设：在12个月随访时，与TAU和WHE+ TAU相比，MABT将减少物质使用和相关健康结局。第二个目的是研究假设的MABT的潜在机制。第三个目的是探索内感受性生物标志物作为治疗结果的预测因子。将招募两个不同社区治疗机构的女性门诊患者参与研究，这些机构为不同种族的患者提供服务。这项研究建立在MABT在女性物质使用障碍治疗中的可行性和可接受性的有希望的初步证据的基础上，并解决了更多旨在改善女性SUD治疗结果的临床研究的需求。

DESCRIPTION (provided by applicant): The long-term objective of this study is to improve women's substance use disorder (SUD) treatment. The immediate project goal is to test the efficacy of an innovative mind-body intervention, Mindful Awareness in Body-Oriented Therapy (MABT) to reduce substance use relapse among women in SUD treatment. A novel mind-body approach, MABT combines a hands-on (manual) approach with mind-body psycho-education approaches of interoceptive training and mindfulness to develop somatically-based self-care skills and to facilitate emotion regulation. A three-group, randomized clinical trial using repeate measures, this project will enroll and randomize 225 women to one of three groups, MABT + Treatment-as-usual (TAU) (n=75), TAU only (n=75), and Women's Health Education (WHE) + TAU (to control for time and attention) (n=75). Study conditions will be compared at baseline, post-intervention, and at 6 and 12 month follow-up. The primary aim is to test the hypothesis that MABT will result in reduced substance use and related health outcomes compared to TAU and to WHE+ TAU at 12 month follow-up. The second aim is to examine hypothesized underlying mechanisms of MABT. The third aim is to explore an interoceptive biomarker as a predictor of treatment outcome. Female outpatients in two diverse community treatment facilities, serving racially diverse patients, will be recruited for study participation. This stud builds on promising preliminary evidence of MABT feasibility and acceptability in substance use disorder treatment for women, and addresses the need for more clinical research aimed at improving SUD treatment outcomes for women.