Electromechanical Modeling Approach in Assessing Female SUI

评估女性 SUI 的机电建模方法

• 批准号: 8692750
• 负责人: Yingchun Zhang
• 金额: $ 23.06万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692750
• 关键词: Aging; Applications Grants; Biomechanics; Biomedical Engineering; Biomedical Research; Clinical; Clinical Research; Elderly; Electrical Engineering; Engineering; Female; Five-Year Plans; Fostering; Functional disorder; Future; Goals; Interdisciplinary Study; Lead; Mechanics; Menopause; Modality; Modeling; Muscle Fatigue; Patients; Pelvis; Prevalence; Research; Research Proposals; Scientist; Stress Urinary Incontinence; Techniques; Testing; Therapeutic; Training; Urethra; Urinary Incontinence; Woman; age effect; base; career; expectation; experience; innovation; interest; minimally invasive; multidisciplinary; novel

As a resubmission, the proposed five-year plan will train me and foster my launch into an independent interdisciplinary research career. My multidisciplinary background in Biomedical Engineering, Electrical Engineering and Mechanical Engineering fields and my outstanding experience in advanced biomechanical modeling and electrophysiological modeling research have fostered my interest and given me unique advantages in conducting interdisciplinary biomedical research in Urinary Incontinence (UI). The immediate goal is to prepare for a career as an independent scientist and to develop a novel subject-specific electromechanical pelvic model based urethrovaginal support and urethral function assessment (UUFA) technique to minimally invasively and quantitatively assess these two etiologic factors and to investigate the specific changes associated with aging effects that cause the increase in prevalence of SUI in women. The central hypothesis behind this research is that urethrovaginal support and urethral function in women and aging effects on female SUI can be minimally invasively and quantitatively assessed and characterized using a subject-specific pelvic modeling approach. Primary Hypothesis #1 is that urethral function in women can be minimally invasively and quantitatively assessed using a subject-specific electrophysiological pelvic modeling approach. Primary Hypothesis #2 is that urethrovaginal support function in women can be non-invasively and quantitatively assessed using a subject-specific biomechanical pelvic modeling approach. Primary Hypothesis #3 is that aging will cause poor urethrovaginal support and/or urethral dysfunction which will lead to SUI. Primary Hypothesis #4 is that a female continence profile can be created to predict the status of continence in women in women clinically and to suggest optimal therapeutic modalities for specific patients. We propose four Specific Aims (SA) to test these Hypotheses: SA #1: To develop a subject- specific electrophysiological pelvic model based periurethral muscle fatigue assessment (UMFA) technique to minimally invasively and quantitatively assess urethral function in women. Primary Hypothesis #1 will be tested. SA #2: To develop a subject-specific biomechanical pelvic model based urethrovaginal support function assessment (USFA) technique to non-invasively and quantitatively assess urethrovaginal support function in women. Primary Hypothesis #2 will be tested. SA #3: To investigate aging effects on urethral function and urethrovaginal support in young/elderly female subjects with/without SUI using the UUFA technique which consists of the UMFA and USFA techniques. Primary Hypothesis #3 will be tested. SA #4: To develop a female SUI profile as a clinical standard of female SUI by utilizing the UUFA technique to quantitatively characterize SUI etiologic factors in urethrovaginal support and urethral function in women. Primary Hypothesis #4 will be tested. At the completion of this project, it is our expectation that we will have established and validated the UUFA technique and the feasibility of its application in clinical studies, and have achieved a better understanding of the contributions of specific changes associated with aging and menopause to these etiologic factors in women.

作为重新提交，拟议的五年计划将训练我，并促进我成为一个独立的 跨学科研究生涯我的多学科背景是生物医学工程，电气 工程和机械工程领域，以及我在先进生物力学方面的杰出经验 建模和电生理建模研究培养了我的兴趣，并给了我独特的 在泌尿系统疾病（UI）进行跨学科生物医学研究的优势。立即 目标是为独立科学家的职业生涯做好准备，并开发一个新的特定主题 基于骨盆机电模型的尿道阴道支撑和尿道功能评估（UUFA） 技术微创和定量评估这两个病因因素，并调查 与衰老效应相关的特定变化导致女性SUI患病率增加。的 这项研究的中心假设是，女性的尿道阴道支持和尿道功能 和衰老对女性SUI的影响可以微创和定量评估， 使用受试者特异性骨盆建模方法表征。第一个假设：尿道 女性的功能可以使用特定于受试者的 电生理骨盆建模方法。主要假设#2是尿道阴道支持功能， 女性可以使用特定对象的生物力学骨盆进行非侵入性和定量评估， 建模方法主要假设#3是老化将导致尿道阴道支持和/或尿道 会导致SUI的功能障碍主要假设#4是，可以创建一个女性生殖器配置文件， 预测临床上女性中女性的子宫内膜异位症的状况，并提出最佳的治疗方式， 具体患者。我们提出了四个具体目标（SA）来测试这些假设：SA #1：开发一个主题- 基于特定电生理骨盆模型尿道周围肌肉疲劳评估（UMFA）技术， 微创和定量评估女性尿道功能。将检验主要假设1。 SA #2：开发基于尿道阴道支撑功能的受试者特定生物力学骨盆模型 评估（USFA）技术，以非侵入性和定量评估尿道阴道支持功能， 妇女将检验主要假设#2。SA #3：研究年龄对尿道功能的影响， 使用UUFA技术，在有/无SUI的年轻/老年女性受试者中进行尿道阴道支持， 由UMFA和USFA技术组成。将检验主要假设#3。SA #4：开发一个 利用UUFA技术定量分析女性SUI的临床标准， 在女性尿道阴道支持和尿道功能方面描述SUI的病因。主要假设 #4将进行测试。在这个项目完成后，我们的期望是，我们将建立和 验证了UUFA技术及其在临床研究中应用的可行性，并取得了良好的效果。 更好地了解与衰老和更年期有关的特定变化对这些疾病的影响， 女性的病因。