Assessing multifactorial etiology of IC/BPS using a novel PFM-Hip-Trunk muscle network analysis
使用新型 PFM-Hip-Trunk 肌肉网络分析评估 IC/BPS 的多因素病因
基本信息
- 批准号:10677557
- 负责人:
- 金额:$ 19.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-05 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AgeBody mass indexCategoriesClinicalCluster AnalysisElectrodesElectromyographyEtiologyFemaleFunctional disorderHealth Care CostsHip region structureImpairmentInterstitial CystitisInterventionLegLower ExtremityMeasuresMuscleMuscle TonusMuscle functionMusculoskeletalMyofascial Pain SyndromesMyofascial Trigger PointNeuromuscular conditionsOutcomeOutcome MeasurePainPathologicPathologyPathway AnalysisPatient Outcomes AssessmentsPatientsPatternPelvic ExaminationPelvic Floor MusclePelvic PainPelvic floor structurePhenotypePhysical therapyPostureQuality of lifeReportingResearchSex BehaviorSignal TransductionStretchingSubgroupSurfaceTechniquesTechnologyTestingTimeWomanWorkchronic pelvic paincomparison controldensitydigitalindividualized medicinemotor impairmentnovelparitypersonalized interventionrecruitsoft tissuestandard caresymptomatic improvement
项目摘要
Abstract
Interstitial cystitis/ bladder pain syndrome (IC/BPS) is one of the most debilitating chronic pelvic pain
(CPP) conditions that negatively impacts the quality of life and sexual activities in 2.7% to 6.5% of
women in the US. Pelvic floor muscle (PFM) overactivity, characterized by an increase in the
tonic muscle activity, is a condition related to myofascial pain that presents in the majority of CPP
conditions, including up to 85% of women with IC/BPS. However, pelvic floor pain is intrinsically a
multifactorial dysfunction that is attributed to postural issues, myofascial trigger points, and abnormal
muscle tone. Myofascial therapy, including specific pelvic floor muscle soft tissue mobilization and
muscle stretching, is standard treatment for patients with IC/BPS and concomitant PFM
tenderness. Unfortunately, even among IC/BPS patients with PFM tenderness on exam, only
59% of patients report symptom improvement after myofascial therapy. Pelvic floor myofascial
therapy, however, does not address movement impairments of the trunk and hips, which are also
associated with pelvic pain. A pelvic floor muscle phenotyping framework would allow IC/BPS
patients to be categorized to facilitate individualized treatment. Unfortunately, no technology is
currently available for quantitatively and objectively assessing PFM etiologic factors associated with
IC/BPS, which, otherwise, would advance the understanding of the underlying mechanisms and
allow for phenotyping patients for appropriate intervention.
Our team has successfully 1) developed a novel intra-vaginal high-density surface
electromyography (HD-sEMG) technique to reliably and quantitatively assess PFM overactivity in
women with IC/BPS and 2) developed a novel muscle network analysis technique to reveal, for
the first time, the inter-muscular connectivity pattern alterations among patients with
neuromuscular conditions, and 3) demonstrated the feasibility to cluster patients with IC/BPS
into phenotypic subgroups, depending on the underlying mechanism. This study aims to
comprehensively assess the PFM overactivity, hip/trunk muscle activity alteration, PFM-to-Hip/
Trunk inter-muscular connectivity, and distinct PFM phenotypic subtypes in IC/BPS. This research
represents the first effort to comprehensively assess the PFM overactivity, hip/trunk muscle activity
alteration, PFM-to-Hip/Trunk inter-muscular connectivity, and distinct PFM phenotypic subtypes in
IC/BPS. The integration of these multifactorial assessments will advance our understanding
of the multifactorial pathology of IC/BPS. The quantification of relative importance of these
pathological contributors will allow for IC/BPS patient phenotyping. Identification of PFM
phenotypic subtypes may facilitate personalized physical therapy treatments.
摘要
间质性膀胱炎/膀胱疼痛综合征(IC/BPS)是最令人衰弱的慢性盆腔疼痛之一
(CPP)对生活质量和性活动产生负面影响的情况占2.7%至6.5%,
美国的女人。骨盆底肌肉(PFM)过度活动,其特征是增加
紧张性肌肉活动,是一种与肌筋膜疼痛相关的疾病,出现在大多数CPP中
条件,包括高达85%的IC/BPS妇女。然而,骨盆底疼痛本质上是一种
归因于姿势问题、肌筋膜触发点和异常的多因素功能障碍
肌肉张力肌筋膜治疗,包括特定的盆底肌肉软组织动员和
肌肉拉伸是IC/BPS伴PFM患者的标准治疗
温柔不幸的是,即使在检查时有PFM压痛的IC/BPS患者中,
59%的患者报告肌筋膜治疗后症状改善。盆底肌筋膜
然而,治疗不能解决躯干和臀部的运动障碍,这也是
与骨盆疼痛相关。骨盆底肌肉表型框架将允许IC/BPS
对患者进行分类,以便于进行个性化治疗。不幸的是,没有技术
目前可用于定量和客观地评估PFM的病因因素与
IC/BPS,否则,将促进对潜在机制的理解,
允许对患者进行表型分析以进行适当的干预。
我们的团队已经成功开发出一种新型的阴道内高密度表面
肌电图(HD-sEMG)技术,以可靠和定量地评估PFM过度活动,
患有IC/BPS的女性和2)开发了一种新的肌肉网络分析技术,
第一次,肌间连接模式改变的患者,
神经肌肉疾病,和3)证明了IC/BPS患者集群的可行性
根据潜在的机制分为表型亚组。本研究旨在
综合评估PFM过度活动、髋/躯干肌肉活动改变、PFM-髋/
躯干肌间连接和IC/BPS中不同的PFM表型亚型。本研究
代表了第一次全面评估PFM过度活动,髋关节/躯干肌肉活动
改变,PFM-髋关节/躯干肌间连接,以及不同的PFM表型亚型,
IC/BPS。这些多因素评估的整合将促进我们的理解
IC/BPS的多因素病理学。这些相对重要性的量化
病理学贡献者将允许IC/BPS患者表型。PFM的识别
表型亚型可能有助于个性化物理治疗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Yingchun Zhang其他文献
Yingchun Zhang的其他文献
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{{ truncateString('Yingchun Zhang', 18)}}的其他基金
ASSESSING MULTIFACTORIAL ETIOLOGY OF OVERACTIVE BLADDER USING A NOVEL PFM-HIP-TRUNK MUSCLE NETWORK ANALYSIS
使用新型 PFM-髋关节-躯干肌肉网络分析评估膀胱过度活动症的多因素病因
- 批准号:
10741259 - 财政年份:2023
- 资助金额:
$ 19.41万 - 项目类别:
High-Density Surface Electromyography Guided Precision Botulinum Neurotoxin Injections to Manage Chronic Pelvic Floor Pain
高密度表面肌电图引导精准肉毒杆菌神经毒素注射治疗慢性盆底疼痛
- 批准号:
10681340 - 财政年份:2022
- 资助金额:
$ 19.41万 - 项目类别:
High-Density Surface Electromyography Guided Precision Botulinum Neurotoxin Injections to Manage Chronic Pelvic Floor Pain
高密度表面肌电图引导精准肉毒杆菌神经毒素注射治疗慢性盆底疼痛
- 批准号:
10512273 - 财政年份:2022
- 资助金额:
$ 19.41万 - 项目类别:
Assessing multifactorial etiology of IC/BPS using a novel PFM-Hip-Trunk muscle network analysis
使用新型 PFM-Hip-Trunk 肌肉网络分析评估 IC/BPS 的多因素病因
- 批准号:
10433025 - 财政年份:2022
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$ 19.41万 - 项目类别:
High-density Surface EMG Assessment of Motor Unit Alterations of the External Anal Sphincter Associated with Aging
高密度表面肌电图评估与衰老相关的肛门外括约肌运动单位改变
- 批准号:
9566428 - 财政年份:2017
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$ 19.41万 - 项目类别:
High density Surface EMG Assessment of the Pelvic Muscle Hypertonicity Associated with Interstitial Cystitis/Bladder Pain Syndrome
高密度表面肌电图评估与间质性膀胱炎/膀胱疼痛综合征相关的盆腔肌肉张力过高
- 批准号:
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Electromechanical Modeling Approach in Assessing Female SUI
评估女性 SUI 的机电建模方法
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8692750 - 财政年份:2013
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Electromechanical Modeling Approach in Assessing Female SUI
评估女性 SUI 的机电建模方法
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8631161 - 财政年份:2013
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Electromechanical Modeling Approach in Assessing Female SUI
评估女性 SUI 的机电建模方法
- 批准号:
8845194 - 财政年份:2013
- 资助金额:
$ 19.41万 - 项目类别:
Electromechanical Modeling Approach in Assessing Female SUI
评估女性 SUI 的机电建模方法
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7989378 - 财政年份:2010
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