Electromechanical Modeling Approach in Assessing Female SUI

评估女性 SUI 的机电建模方法

• 批准号: 8845194
• 负责人: Yingchun Zhang
• 金额: $ 21.83万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8845194
• 关键词: Aging; Applications Grants; Biomechanics; Biomedical Engineering; Biomedical Research; Clinical; Clinical Research; Elderly; Electrical Engineering; Engineering; Female; Five-Year Plans; Fostering; Functional disorder; Future; Goals; Interdisciplinary Study; Lead; Mechanics; Menopause; Modality; Modeling; Muscle Fatigue; Patients; Pelvis; Prevalence; Research; Research Proposals; Scientist; Stress Urinary Incontinence; Techniques; Testing; Therapeutic; Training; Urethra; Urinary Incontinence; Woman; age effect; base; biomechanical model; career; expectation; experience; innovation; interest; minimally invasive; multidisciplinary; novel

As a resubmission, the proposed five-year plan will train me and foster my launch into an independent interdisciplinary research career. My multidisciplinary background in Biomedical Engineering, Electrical Engineering and Mechanical Engineering fields and my outstanding experience in advanced biomechanical modeling and electrophysiological modeling research have fostered my interest and given me unique advantages in conducting interdisciplinary biomedical research in Urinary Incontinence (UI). The immediate goal is to prepare for a career as an independent scientist and to develop a novel subject-specific electromechanical pelvic model based urethrovaginal support and urethral function assessment (UUFA) technique to minimally invasively and quantitatively assess these two etiologic factors and to investigate the specific changes associated with aging effects that cause the increase in prevalence of SUI in women. The central hypothesis behind this research is that urethrovaginal support and urethral function in women and aging effects on female SUI can be minimally invasively and quantitatively assessed and characterized using a subject-specific pelvic modeling approach. Primary Hypothesis #1 is that urethral function in women can be minimally invasively and quantitatively assessed using a subject-specific electrophysiological pelvic modeling approach. Primary Hypothesis #2 is that urethrovaginal support function in women can be non-invasively and quantitatively assessed using a subject-specific biomechanical pelvic modeling approach. Primary Hypothesis #3 is that aging will cause poor urethrovaginal support and/or urethral dysfunction which will lead to SUI. Primary Hypothesis #4 is that a female continence profile can be created to predict the status of continence in women in women clinically and to suggest optimal therapeutic modalities for specific patients. We propose four Specific Aims (SA) to test these Hypotheses: SA #1: To develop a subject- specific electrophysiological pelvic model based periurethral muscle fatigue assessment (UMFA) technique to minimally invasively and quantitatively assess urethral function in women. Primary Hypothesis #1 will be tested. SA #2: To develop a subject-specific biomechanical pelvic model based urethrovaginal support function assessment (USFA) technique to non-invasively and quantitatively assess urethrovaginal support function in women. Primary Hypothesis #2 will be tested. SA #3: To investigate aging effects on urethral function and urethrovaginal support in young/elderly female subjects with/without SUI using the UUFA technique which consists of the UMFA and USFA techniques. Primary Hypothesis #3 will be tested. SA #4: To develop a female SUI profile as a clinical standard of female SUI by utilizing the UUFA technique to quantitatively characterize SUI etiologic factors in urethrovaginal support and urethral function in women. Primary Hypothesis #4 will be tested. At the completion of this project, it is our expectation that we will have established and validated the UUFA technique and the feasibility of its application in clinical studies, and have achieved a better understanding of the contributions of specific changes associated with aging and menopause to these etiologic factors in women.

作为一个重新提交，拟议的五年计划将训练我，并促进我成为一个独立的

项目成果

Pelvic floor dynamics during high-impact athletic activities: A computational modeling study.

• DOI: 10.1016/j.clinbiomech.2016.11.003
• 发表时间: 2017-01
• 期刊: Clinical biomechanics (Bristol, Avon)
• 作者: Dias N;Peng Y;Khavari R;Nakib NA;Sweet RM;Timm GW;Erdman AG;Boone TB;Zhang Y
• 通讯作者: Zhang Y

Functional mapping of the pelvic floor and sphincter muscles from high-density surface EMG recordings.

• DOI: 10.1007/s00192-016-3026-4
• 发表时间: 2016-11
• 期刊: International urogynecology journal
• 影响因子: 1.8
• 作者: Peng Y;He J;Khavari R;Boone TB;Zhang Y
• 通讯作者: Zhang Y