Training in Cell Signaling and Lung Pathobiology

本续签申请请求继续支持“细胞”博士前/短期培训项目 信号传导和肺病理学”，位于南阿拉巴马大学肺生物学中心 医学院。随着我们培训计划的博士前部分通过第一轮的成熟 资金（2004-2009），我们在第二个周期（2009-2014）增加了短期培训以支持夏季 研究经验。鉴于我们的培训取得了成功，在此续签申请中，我们要求继续 支持博士前实习生（6 个名额）和医学生实习生短期暑期研究（4 个名额） 插槽）。培训的研究领域包括肺血管收缩和血管收缩的机制 肺动脉高压重塑、血管和气道平滑肌生物学、肺调节 内皮屏障功能、急性肺损伤、氧化应激中的线粒体功能和信号传导，以及 离子通道参与气道上皮和血管内皮功能。我们的计划，其中 仍然是美国南部仅有的三个提供肺部研究博士前培训的机构之一，将与 由博士指导。玛丽·汤斯利 (Mary Townsley) 和特洛伊·史蒂文斯 (Troy Stevens) 与内部咨询委员会协商， 由杰出的外部顾问进行年度审查。培训计划的总体构建基于 美国国立卫生研究院和其他国家科学领导小组高度重视广泛的跨学科培训。 我们的博士前培训计划的基础设施由跨学科核心课程提供 基础医学博士程序。博士前培训生将获得T32 2-3年的支持。 这些学员致力于肺生物学课程，从项目教师中挑选一位导师，并 完成信号、生物统计学/实验设计和肺方面严格的教学高级课程 生物学/病理学。除了正式的学术课程外，博士前培训生还将参加 研讨会和正在进行的研究期刊俱乐部，以及出色的职业生存技能培训 由肺生物学中心组织。短期学员进入长期井然有序的暑假 医学生研究计划。这些学员将完成为期 10 周的研究项目，重点关注 肺生物学/病理生物学与项目教员之一。暑期培训包括必需的研讨会 系列。我们的培训计划受益于 25 名资金充足、实力雄厚的人的研究和指导专业知识。 来自医学院五个系的合作和国家认可的教师，所有附属 与肺生物学中心。我们的目标是提供一个充满活力的培训环境，让学员做好准备 以便在学术、工业和/或政府生物医学研究场所从事后续职业。

This renewal application requests continued support for the predoctoral/short-term training program in "Cell signaling and lung pathobiology" based in the Center for Lung Biology at the University of South Alabama College of Medicine. As the predoctoral component of our training program matured through the first cycle of funding (2004-2009), we added short-term training in the second cycle (2009-2014) to support summer research experiences. Given our success with training, in this renewal application we request continued support for both predoctoral trainees (6 slots) and medical student trainees in short term summer research (4 slots). Research areas for training include mechanisms underlying pulmonary vasoconstriction and vascular remodeling in pulmonary hypertension, vascular and airway smooth muscle biology, regulation of lung endothelial barrier function, acute lung injury, mitochondrial function and signaling in oxidant stress, and involvement of ion channels in airway epithelium and vascular endothelium function. Our program, which continues to be one of only three in the southern US providing predoctoral training in lung research, will be co- directed by Drs. Mary Townsley and Troy Stevens, in consultation with an Internal Advisory Committee and annual review by distinguished External Advisors. The overall construct of the training program is based upon the strong emphasis by NIH and other national science leadership groups on broad, interdisciplinary training. The infrastructure for our predoctoral training program is provided by an interdisciplinary core curriculum in the Basic Medical Sciences Ph.D. program. Predoctoral trainees will be supported by the T32 for 2-3 years. These trainees commit to the lung biology track, identify a mentor from among the program faculty and complete a rigorous didactic advanced curriculum in signaling, biostatistics/experimental design, and lung biology/pathobiology. In addition to formal academic coursework, predoctoral trainees will participate in seminars and the Research-in-Progress journal club, as well as outstanding career survival skills training organized by the Center for Lung Biology. Short-term trainees enter a long-standing well-organized summer research program for medical students. These trainees will complete a 10-week research project focused on lung biology/pathobiology with one of the program faculty. Summer training includes a required seminar series. Our training program benefits from the research and mentoring expertise of 25 well-funded, highly collaborative and nationally-recognized faculty from five departments in the College of Medicine, all affiliated with the Center for Lung Biology. Our goal is to provide a vibrant training environment that prepares trainees for subsequent careers in academic, industry and/or government biomedical research venues.