Training in Cell Signaling and Lung Pathobiology

此续订申请请求继续支持“Cell”中的博士前/短期培训计划 南阿拉巴马大学肺生物学中心的信号与肺部病理生物学 医学院。随着我们培训计划的博士前部分在第一个周期中成熟 为资助(2004-2009年)，我们在第二个周期(2009-2014年)增加了短期培训，以支持夏季 研究经验。鉴于我们在培训方面取得的成功，在此续订申请中，我们要求继续 支持博士前实习生(6个名额)和医科学生实习生短期暑期研究(4 插槽)。培训的研究领域包括肺血管收缩和血管的潜在机制 肺高压、血管和气道平滑肌生物学、肺调节中的重构 氧化应激中的内皮屏障功能、急性肺损伤、线粒体功能和信号转导 离子通道参与呼吸道上皮和血管内皮细胞功能。我们的节目， 继续是美国南部仅有的三家提供肺部研究博士前培训的机构之一，将与 由玛丽·汤斯利博士和特洛伊·史蒂文斯博士执导，与内部咨询委员会和 杰出外部顾问的年度审查。培训计划的总体结构是基于 美国国立卫生研究院和其他国家科学领导小组对广泛的跨学科培训的强烈重视。 我们的博士前培训计划的基础设施是由 基础医学博士项目。博士前实习生将由T32资助2-3年。 这些受训人员致力于肺部生物学研究，从项目教职员工中寻找导师，并 完成信号、生物统计学/实验设计和肺的严格教学高级课程 生物学/病理生物学。除了正式的学术课程外，博士前实习生还将参加 研讨会和正在进行的期刊俱乐部，以及出色的职业生存技能培训 由肺生物学中心组织。短期实习生进入一个长期组织良好的暑期 医科学生的研究项目。这些受训者将完成一个为期10周的研究项目，重点是 肺部生物学/病理生物学与其中一名项目教员。暑期培训包括必修的研讨会。 系列片。我们的培训计划得益于25家资金雄厚、高度 来自医学院五个系的合作和国家认可的教职员工，所有附属 在肺生物学中心工作。我们的目标是提供一个充满活力的培训环境，为学员做好准备 未来在学术、行业和/或政府生物医学研究场所的职业生涯。

This renewal application requests continued support for the predoctoral/short-term training program in "Cell signaling and lung pathobiology" based in the Center for Lung Biology at the University of South Alabama College of Medicine. As the predoctoral component of our training program matured through the first cycle of funding (2004-2009), we added short-term training in the second cycle (2009-2014) to support summer research experiences. Given our success with training, in this renewal application we request continued support for both predoctoral trainees (6 slots) and medical student trainees in short term summer research (4 slots). Research areas for training include mechanisms underlying pulmonary vasoconstriction and vascular remodeling in pulmonary hypertension, vascular and airway smooth muscle biology, regulation of lung endothelial barrier function, acute lung injury, mitochondrial function and signaling in oxidant stress, and involvement of ion channels in airway epithelium and vascular endothelium function. Our program, which continues to be one of only three in the southern US providing predoctoral training in lung research, will be co- directed by Drs. Mary Townsley and Troy Stevens, in consultation with an Internal Advisory Committee and annual review by distinguished External Advisors. The overall construct of the training program is based upon the strong emphasis by NIH and other national science leadership groups on broad, interdisciplinary training. The infrastructure for our predoctoral training program is provided by an interdisciplinary core curriculum in the Basic Medical Sciences Ph.D. program. Predoctoral trainees will be supported by the T32 for 2-3 years. These trainees commit to the lung biology track, identify a mentor from among the program faculty and complete a rigorous didactic advanced curriculum in signaling, biostatistics/experimental design, and lung biology/pathobiology. In addition to formal academic coursework, predoctoral trainees will participate in seminars and the Research-in-Progress journal club, as well as outstanding career survival skills training organized by the Center for Lung Biology. Short-term trainees enter a long-standing well-organized summer research program for medical students. These trainees will complete a 10-week research project focused on lung biology/pathobiology with one of the program faculty. Summer training includes a required seminar series. Our training program benefits from the research and mentoring expertise of 25 well-funded, highly collaborative and nationally-recognized faculty from five departments in the College of Medicine, all affiliated with the Center for Lung Biology. Our goal is to provide a vibrant training environment that prepares trainees for subsequent careers in academic, industry and/or government biomedical research venues.