Training in Cell Signaling and Lung Pathobiology

此更新申请要求继续支持博士前/短期培训计划“细胞 信号传导和肺病理生物学”，位于南亚拉巴马大学肺生物学中心 医学院。随着我们的培训计划的博士前部分通过第一个周期的成熟， 在第二个周期（2009 - 2014年），我们增加了短期培训，以支持夏季 研究经验。鉴于我们在培训方面取得的成功，在此更新申请中，我们要求继续 为博士前实习生（6个名额）和短期暑期研究医学生实习生（4个名额）提供支助 插槽）。培训的研究领域包括肺血管收缩和血管收缩的潜在机制。 肺动脉高压的重塑，血管和气道平滑肌生物学，肺的调节 内皮屏障功能、急性肺损伤、氧化应激中的线粒体功能和信号传导，以及 气道上皮和血管内皮功能中离子通道的参与。我们的计划， 继续是美国南部仅有的三个提供肺部研究博士前培训的大学之一，将与 由玛丽汤斯利和特洛伊史蒂文斯博士指导，与内部咨询委员会协商， 由杰出的外部顾问进行年度审查。培训计划的总体结构是基于 国家卫生研究院和其他国家科学领导小组对广泛的跨学科培训的高度重视。 我们的博士前培训计划的基础设施是由一个跨学科的核心课程， 基础医学博士程序.博士前学员将由T32支持2-3年。 这些学员致力于肺部生物学轨道，从计划教师中确定导师， 完成信号，生物统计学/实验设计和肺的严格教学高级课程 生物学/病理生物学除了正式的学术课程外，博士前学员还将参加 研讨会和研究进展期刊俱乐部，以及出色的职业生存技能培训 由肺生物学中心组织。短期实习生进入一个长期存在的组织良好的夏季 医学生的研究项目。这些学员将完成一个为期10周的研究项目， 肺生物学/病理生物学与程序的教员之一。暑期培训包括一个必要的研讨会 系列.我们的培训计划受益于25个资金充足，高度专业化的研究和指导 协作和国家认可的教师从五个部门在医学院，所有附属 肺部生物学中心的研究我们的目标是提供一个充满活力的培训环境， 在学术，工业和/或政府生物医学研究场所的后续职业生涯。

This renewal application requests continued support for the predoctoral/short-term training program in "Cell signaling and lung pathobiology" based in the Center for Lung Biology at the University of South Alabama College of Medicine. As the predoctoral component of our training program matured through the first cycle of funding (2004-2009), we added short-term training in the second cycle (2009-2014) to support summer research experiences. Given our success with training, in this renewal application we request continued support for both predoctoral trainees (6 slots) and medical student trainees in short term summer research (4 slots). Research areas for training include mechanisms underlying pulmonary vasoconstriction and vascular remodeling in pulmonary hypertension, vascular and airway smooth muscle biology, regulation of lung endothelial barrier function, acute lung injury, mitochondrial function and signaling in oxidant stress, and involvement of ion channels in airway epithelium and vascular endothelium function. Our program, which continues to be one of only three in the southern US providing predoctoral training in lung research, will be co- directed by Drs. Mary Townsley and Troy Stevens, in consultation with an Internal Advisory Committee and annual review by distinguished External Advisors. The overall construct of the training program is based upon the strong emphasis by NIH and other national science leadership groups on broad, interdisciplinary training. The infrastructure for our predoctoral training program is provided by an interdisciplinary core curriculum in the Basic Medical Sciences Ph.D. program. Predoctoral trainees will be supported by the T32 for 2-3 years. These trainees commit to the lung biology track, identify a mentor from among the program faculty and complete a rigorous didactic advanced curriculum in signaling, biostatistics/experimental design, and lung biology/pathobiology. In addition to formal academic coursework, predoctoral trainees will participate in seminars and the Research-in-Progress journal club, as well as outstanding career survival skills training organized by the Center for Lung Biology. Short-term trainees enter a long-standing well-organized summer research program for medical students. These trainees will complete a 10-week research project focused on lung biology/pathobiology with one of the program faculty. Summer training includes a required seminar series. Our training program benefits from the research and mentoring expertise of 25 well-funded, highly collaborative and nationally-recognized faculty from five departments in the College of Medicine, all affiliated with the Center for Lung Biology. Our goal is to provide a vibrant training environment that prepares trainees for subsequent careers in academic, industry and/or government biomedical research venues.