Determinants of Pulmonary Endothelial Cell Function Conf

描述（由申请人提供）：新出现的证据表明，肺大血管内皮细胞和微血管内皮细胞起源于不同的胚胎学（如表观遗传）起源，并且这些细胞在胚胎、胎儿和成人生活中保持分化。因此，宏观和微血管内皮细胞的表型受表观遗传和环境因素的双重控制。细胞表型的表观遗传和环境控制之间的相互作用知之甚少，并且这种表型调节的临床意义直到最近才被考虑。因此，本申请寻求资金支持2004年格罗弗肺循环会议，题为“肺内皮细胞功能的遗传和环境决定因素”，以评估内皮细胞表型的表观遗传和环境调节之间的相互作用。具体而言，2004年格罗弗会议旨在为内皮细胞和血管生物学专家提供一个论坛，以严格解决：(1)宏观和微血管内皮细胞的表观遗传起源；(2)通过激活表型不同的内皮细胞中独特的信号网络来控制细胞功能；(3)内皮细胞可塑性；(4)内皮作为医学上的治疗靶点。本次会议的会议记录将作为一本特别的图书版本散发，由Futura出版。我们要求为演讲者提供部分旅费和住宿费。2004年格罗弗会议将是这个系列的第12次会议，代表了肺循环方面历史最悠久的会议，并将在科罗拉多州锡代利亚的失落谷牧场举行。与以前的形式一样，将给予同等的时间进行介绍和讨论，以优化该领域专家之间的科学交流。在本次会议结束时，作为已发表报告的一部分，我们将确定肺血管生物学未来需要研究的领域。

DESCRIPTION (provided by applicant): Emerging evidence intimates that lung macro- and microvascular endothelial cells arise from distinct embryological (e.g. epigenetic) origins and, further, that these cells remain differentiated throughout embryonic, fetal and adult life. Thus, macro- and microvascular endothelial cell phenotype is controlled by both epigenetic and environmental factors. Interplay between epigenetic and environmental control of cell phenotype is poorly understood, and the clinical implications of such phenotype regulation have only recently been considered. Thus, this application seeks funding to support the 2004 Grover Conference on the Pulmonary Circulation, entitled Genetic and Environmental Determinants of Pulmonary Endothelial Cell Function, to assess the interplay between epigenetic and environmental regulation of endothelial cell phenotype. Specifically, the 2004 Grover Conference seeks to provide a forum for experts in endothelial cell and vascular biology to rigorously address: (1) The epigenetic origin of macro- and microvascular endothelial cells; (2) Control of cell function through activation of unique signaling networks in phenotypically distinct endothelia; (3) Endothelial cell plasticity; and, (4) Endothelium as a therapeutic target in medicine. Proceedings from this meeting will be disseminated as a special book edition, published by Futura. We request funding for partial support of travel and lodging for speakers. The 2004 Grover Conference will be the 12th in this series, representing the longest-standing conference on the Pulmonary Circulation, and will be held at the Lost Valley Ranch in Sedalia, Colorado. As in earlier formats, equal time will be given to presentation and discussion to optimize scientific interchange among experts in the field. At the conclusion of this meeting and as part of the published report, we will have identified areas of need for future investigation in lung vascular biology.