IGF::OT::IGF Conference support for GAME-ON Steering commitee meeting

国家癌症研究所(NCI)流行病学和基因组研究计划(EGRP)位于癌症控制和人口科学部(DCCPS)，其使命是资助人类人口研究，以了解癌症的原因和相关结果。该计划促进跨学科合作以及资源和技术的开发和使用，以促进癌症研究及其翻译，作为临床和公共卫生干预的基础。肿瘤学中的遗传关联机制(GAME-ON)是由EGRP资助的研究的一个很好的例子。 GAME-ON由流行病学家、基础科学家和临床医生组成的五个多学科团队组成，他们合作研究与乳腺癌、结肠癌、卵巢癌、前列腺癌和肺癌的易感性有关的基因组区域。GAME-ON将通过复制先前的发现，更好地定位参与癌症易感性的基因组区域，并揭开遗传变异的功能后果以及环境因素如何影响遗传效应，从而迅速从最初的癌症GWA取得有希望的线索，以便为将这些发现转化为临床和预防应用奠定基础。由于一些原因，规定的面对面会议是必要的，例如建立内部结构和政策、讨论和规划协作项目以及及早报告尚未公布的研究成果。

The mission of the National Cancer Institute’s (NCI) Epidemiology and Genomics Research Program (EGRP), in the Division of Cancer Control and Population Science (DCCPS), is to fund research in human populations in order to understand the causes of cancer and related outcomes. The Program fosters interdisciplinary collaborations and the development and use of resources and technologies to advance cancer research and its translation to serve as the basis for clinical and public health interventions. The Genetic Association mechanisms in Oncology (GAME-ON), a Cancer Post-GWAS Initiative, is a great example of the research funded by EGRP. GAME-ON consists of five multidisciplinary teams of epidemiologists, basic scientists, and clinicians who are collaborating to investigate genomic regions that have been implicated in susceptibility to breast, colon, ovarian, prostate, and lung cancer. GAME-ON will rapidly move forward promising leads from initial cancer GWAS by replicating prior findings, better pinpointing genomic regions involved in cancer susceptibility, and unraveling the functional consequences of genetic variants and how environmental factors may influence the genetic effect, in order to set the stage for translating these findings into clinical and prevention applications. The mandated in-person meetings are essential for a number of reasons, such as establishment of internal structures and policies, discussion and planning of collaborative projects and early reporting of yet unpublished research results.