德克萨斯州神经艾滋病研究中心-猫眼课题宝

德克萨斯州神经艾滋病研究中心

批准号：

8657114

负责人：

BENJAMIN B. GELMAN

金额：

$113.99万

依托单位：

UNIVERSITY OF TEXAS MED BR GALVESTON

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-05-01 至 2018-04-30

来源：

https://reporter.nih.gov/project-details/8657114

关键词：

AIDS neuropathy AIDS/HIV problem Address Adherence Aging Agreement Alcohol or Other Drugs use Applications Grants Authorization documentation Automobile Driving Autopsy Award Basic Science Biological Assay Biological Markers Blood specimen Boxing Brain Budgets Censuses Central Nervous System Diseases Cerebrospinal Fluid Certification Characteristics Chemicals Client Clinic Clinic Visits Clinical Clinical Data Clinical Sciences Cognition Disorders Collaborations Collection Communities Confidential Information Cost Allocation Country Data Data Coordinating Center Development Diagnosis Direct Costs Disclosure Disease Ensure Equipment and supply inventories Evaluation Face Facilities and Administrative Costs Frequencies Funding Future Gender Gene Expression Goals Government Grant HIV HIV Infections Hematoxylin and Eosin Staining Method Highly Active Antiretroviral Therapy Immunosuppression Income Individual Information Management Informed Consent Institution Instruction Investigation Investigator-Initiated Research Investments Lead Life Mails Measures Mediation Medical Methods Names Neurocognitive Neurologic Neurologic Examination Neuropsychological Tests Neuropsychology Participant Pathology Patient Self-Report Patients Play Policies Population Principal Investigator Procedures Protocols documentation Quality Control Recruitment Activity Reporting Research Research Personnel Research Support Resources Role Schedule Site Source Specimen Spinal Puncture Structure Surveys Telephone Texas Time Tissues Training United States National Institutes of Health Viral Load result Virus Replication Visit Wages base clinical research site cohort cost expedited review high risk human old age (65+)improved in vivo innovation interest mortality neuropathology neuropsychological novel strategies operation outcome forecast peer programs public health relevance quality assurance racial and ethnic repository response therapeutic target

中文摘要

翻译

描述(由申请人提供)：国家神经艾滋病组织联盟(NNTC)是一个集体组织和数据资源计划，德克萨斯州神经艾滋病研究中心(TNRC；B.Gelman，PI)自1998年开始一直作为贡献网站参与其中。NNTC的目的是收集和分发纵向跟踪的艾滋病毒感染者的关键临床数据和组织标本，这些人是艾滋病毒相关神经认知障碍(HAND)的高危人群，以支持研究人员在整个神经艾滋病社区发起的创新和变革性研究。除了提供组织样本外，NNTC还为研究人员提供了相关的体内生物标记物、病毒载量、基因表达数据、神经病理变化和相关的手认知状态。这使得临床和基础科学水平的研究人员能够将这些关键措施纳入到驱动手的机制、艾滋病毒感染的艾滋病毒相关病理效应或潜在的手治疗目标的调查中。TNRC申请的广泛目标是继续提供从当地招募的(德克萨斯人)艾滋病毒队列中获得的此类资源，并进一步发展这一当地资源和NNTC在解决HAART时代神经艾滋病社区目前不断变化的和未来的资源需求方面的集体力量。该网站特别侧重于充分利用其研究价值的资源收集和利用战略。要求继续支持诊所现场运营的申请涉及一般操作程序的所有方面。包括招募实践、神经心理评估、物质使用调查、神经医学方案、尸检程序和标本存储库管理。提出了促进联合体目标并与全国过渡委员会其他单位实现协同增效的战略。TNRC的持续运作将对寻找治疗手部、中枢神经系统老化和其他艾滋病毒相关病理疾病的药物产生持久和积极的影响。

英文摘要

DESCRIPTION (provided by applicant): The National NeuroAIDS Tissue Consortium (NNTC) is a collective tissue and data resourcing program in which the Texas NeuroAIDS Research Center (TNRC; B. Gelman, PI) has continuously participated as a contributing site since Inception In 1998. The NNTC's purpose Is to collect and distribute critical clinical data and tissue specimens from longitudinally-tracked HIV-infected Individuals at high risk for HIV-associated neurocognitive disorders (HAND) to support Innovative and transformative Investigator-Initiated research In the NeuroAIDS community at large. Beyond supplying tissue specimens the NNTC provides researchers access to relevant in vivo biomarkers, viral loads, gene expression data, neuropathological changes, and associated HAND cognitive status. This enables clinical and basic science-level researchers to incorporate these critical measures Into Investigations of the mechanisms driving HAND, HIV-associated pathological effects of HIV Infection, or potential HAND therapeutic targets. The broad aim of the TNRC application is to continue to provide such resources derived from locally-recruited (Texan) HIV cohorts and to further develop this local resource and the collective strength of the NNTC in addressing the currently changing and future resource needs of the NeuroAIDS community In the HAART era. The TNRC site focuses particularly on resource collection and utilization strategies that fully exploit their research value. The application for continued support to operate the clinic site addresses all aspects of the general operating procedures. Included are recruiting practices, neuropsychological evaluations, substance use surveys, neuromedical protocols, autopsy procedure, and specimen repository management. Strategies to contribute to consortium goals and obtain synergy with the other units of the NNTC are proposed. Continued operation of TNRC will have a lasting and positive impact on the search for remedies for HAND, CNS aging, and other HIV- associated pathological conditions.

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