德克萨斯州神经艾滋病研究中心-猫眼课题宝

德克萨斯州神经艾滋病研究中心

批准号：

8657114

负责人：

BENJAMIN B. GELMAN

金额：

$113.99万

依托单位：

UNIVERSITY OF TEXAS MED BR GALVESTON

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-05-01 至 2018-04-30

来源：

https://reporter.nih.gov/project-details/8657114

关键词：

AIDS neuropathy AIDS/HIV problem Address Adherence Aging Agreement Alcohol or Other Drugs use Applications Grants Authorization documentation Automobile Driving Autopsy Award Basic Science Biological Assay Biological Markers Blood specimen Boxing Brain Budgets Censuses Central Nervous System Diseases Cerebrospinal Fluid Certification Characteristics Chemicals Client Clinic Clinic Visits Clinical Clinical Data Clinical Sciences Cognition Disorders Collaborations Collection Communities Confidential Information Cost Allocation Country Data Data Coordinating Center Development Diagnosis Direct Costs Disclosure Disease Ensure Equipment and supply inventories Evaluation Face Facilities and Administrative Costs Frequencies Funding Future Gender Gene Expression Goals Government Grant HIV HIV Infections Hematoxylin and Eosin Staining Method Highly Active Antiretroviral Therapy Immunosuppression Income Individual Information Management Informed Consent Institution Instruction Investigation Investigator-Initiated Research Investments Lead Life Mails Measures Mediation Medical Methods Names Neurocognitive Neurologic Neurologic Examination Neuropsychological Tests Neuropsychology Participant Pathology Patient Self-Report Patients Play Policies Population Principal Investigator Procedures Protocols documentation Quality Control Recruitment Activity Reporting Research Research Personnel Research Support Resources Role Schedule Site Source Specimen Spinal Puncture Structure Surveys Telephone Texas Time Tissues Training United States National Institutes of Health Viral Load result Virus Replication Visit Wages base clinical research site cohort cost expedited review high risk human old age (65+)improved in vivo innovation interest mortality neuropathology neuropsychological novel strategies operation outcome forecast peer programs public health relevance quality assurance racial and ethnic repository response therapeutic target

中文摘要

翻译

描述（由申请人提供）：国家神经艾滋病组织联盟（NNTC）是一个集体组织和数据资源计划，德克萨斯神经艾滋病研究中心（TNRC； B. Gelman， PI）自1998年成立以来一直作为贡献站点参与其中。NNTC的目的是收集和分发关键的临床数据和组织标本，这些数据和组织标本来自纵向追踪的hiv相关神经认知障碍（HAND）高危hiv感染者，以支持神经艾滋病社区的创新和变革性研究者发起的研究。除了提供组织标本外，NNTC还为研究人员提供了相关的体内生物标志物、病毒载量、基因表达数据、神经病理变化和相关的HAND认知状态。这使得临床和基础科学水平的研究人员能够将这些关键措施纳入驱动HAND的机制，HIV相关的HIV感染病理效应或潜在的HAND治疗靶点的研究中。TNRC申请的广泛目标是继续提供来自当地招募的（德克萨斯）HIV队列的资源，并进一步开发这种当地资源和NNTC的集体力量，以解决HAART时代神经艾滋病社区当前变化和未来的资源需求。TNRC网站特别侧重于充分开发其研究价值的资源收集和利用策略。申请继续支持诊所的运作，涉及一般操作程序的各个方面。包括招募实践、神经心理学评估、物质使用调查、神经医学协议、尸检程序和标本库管理。提出了有助于实现联盟目标并与NNTC其他单位取得协同效应的策略。TNRC的持续运作将对寻找治疗HAND、中枢神经系统老化和其他HIV相关病理状况的方法产生持久和积极的影响。

英文摘要

DESCRIPTION (provided by applicant): The National NeuroAIDS Tissue Consortium (NNTC) is a collective tissue and data resourcing program in which the Texas NeuroAIDS Research Center (TNRC; B. Gelman, PI) has continuously participated as a contributing site since Inception In 1998. The NNTC's purpose Is to collect and distribute critical clinical data and tissue specimens from longitudinally-tracked HIV-infected Individuals at high risk for HIV-associated neurocognitive disorders (HAND) to support Innovative and transformative Investigator-Initiated research In the NeuroAIDS community at large. Beyond supplying tissue specimens the NNTC provides researchers access to relevant in vivo biomarkers, viral loads, gene expression data, neuropathological changes, and associated HAND cognitive status. This enables clinical and basic science-level researchers to incorporate these critical measures Into Investigations of the mechanisms driving HAND, HIV-associated pathological effects of HIV Infection, or potential HAND therapeutic targets. The broad aim of the TNRC application is to continue to provide such resources derived from locally-recruited (Texan) HIV cohorts and to further develop this local resource and the collective strength of the NNTC in addressing the currently changing and future resource needs of the NeuroAIDS community In the HAART era. The TNRC site focuses particularly on resource collection and utilization strategies that fully exploit their research value. The application for continued support to operate the clinic site addresses all aspects of the general operating procedures. Included are recruiting practices, neuropsychological evaluations, substance use surveys, neuromedical protocols, autopsy procedure, and specimen repository management. Strategies to contribute to consortium goals and obtain synergy with the other units of the NNTC are proposed. Continued operation of TNRC will have a lasting and positive impact on the search for remedies for HAND, CNS aging, and other HIV- associated pathological conditions.

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