德克萨斯神经艾滋病研究中心-猫眼课题宝

德克萨斯神经艾滋病研究中心

批准号：

8846672

负责人：

BENJAMIN B. GELMAN

金额：

$114.11万

依托单位：

UNIVERSITY OF TEXAS MED BR GALVESTON

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-05-01 至 2016-02-29

来源：

https://reporter.nih.gov/project-details/8846672

关键词：

AIDS/HIV problem Address Adherence Aging Agreement Alcohol or Other Drugs use Applications Grants Authorization documentation Automobile Driving Autopsy Award Basic Science Biological Assay Biological Markers Blood specimen Boxing Brain Budgets Censuses Cerebrospinal Fluid Certification Characteristics Chemicals Client Clinic Clinic Visits Clinical Clinical Data Clinical Sciences Cognitive Collaborations Collection Communities Confidential Information Cost Allocation Country Data Data Coordinating Center Development Diagnosis Direct Costs Disclosure Ensure Equipment and supply inventories Evaluation Face Facilities and Administrative Costs Frequencies Funding Future Gender Gene Expression Goals Government Grant HIV HIV Infections HIV-associated neurocognitive disorder Health Hematoxylin and Eosin Staining Method Highly Active Antiretroviral Therapy Immunosuppression Income Individual Information Management Informed Consent Institution Instruction Investigation Investigator-Initiated Research Investments Lead Life Measures Mediation Medical Methods Names Neurologic Neurologic Examination Neuropsychological Tests Neuropsychology Participant Pathology Patient Self-Report Patients Play Policies Population Principal Investigator Procedures Protocols documentation Quality Control Recruitment Activity Reporting Research Research Personnel Research Support Resources Role Schedule Site Source Specimen Spinal Puncture Structure Surveys Telephone Texas Time Tissues Training United States National Institutes of Health Viral Load result Virus Replication Visit Wages base clinical research site cohort cost expedited review high risk human old age (65+)improved in vivo innovation interest mortality neuroAIDS neuropathology neuropsychological novel strategies operation outcome forecast peer programs quality assurance racial and ethnic repository response therapeutic target

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DESCRIPTION (provided by applicant): The National NeuroAIDS Tissue Consortium (NNTC) is a collective tissue and data resourcing program in which the Texas NeuroAIDS Research Center (TNRC; B. Gelman, PI) has continuously participated as a contributing site since Inception In 1998. The NNTC's purpose Is to collect and distribute critical clinical data and tissue specimens from longitudinally-tracked HIV-infected Individuals at high risk for HIV-associated neurocognitive disorders (HAND) to support Innovative and transformative Investigator-Initiated research In the NeuroAIDS community at large. Beyond supplying tissue specimens the NNTC provides researchers access to relevant in vivo biomarkers, viral loads, gene expression data, neuropathological changes, and associated HAND cognitive status. This enables clinical and basic science-level researchers to incorporate these critical measures Into Investigations of the mechanisms driving HAND, HIV-associated pathological effects of HIV Infection, or potential HAND therapeutic targets. The broad aim of the TNRC application is to continue to provide such resources derived from locally-recruited (Texan) HIV cohorts and to further develop this local resource and the collective strength of the NNTC in addressing the currently changing and future resource needs of the NeuroAIDS community In the HAART era. The TNRC site focuses particularly on resource collection and utilization strategies that fully exploit their research value. The application for continued support to operate the clinic site addresses all aspects of the general operating procedures. Included are recruiting practices, neuropsychological evaluations, substance use surveys, neuromedical protocols, autopsy procedure, and specimen repository management. Strategies to contribute to consortium goals and obtain synergy with the other units of the NNTC are proposed. Continued operation of TNRC will have a lasting and positive impact on the search for remedies for HAND, CNS aging, and other HIV- associated pathological conditions.

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