Texas NeuroAIDS Research Center

德克萨斯神经艾滋病研究中心

• 批准号: 10353375
• 负责人: BENJAMIN B. GELMAN
• 金额: $ 126.51万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10353375
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Age; Aging; Applications Grants; Automobile Driving; Autopsy; Basic Science; Biological Assay; Biological Markers; Biological Specimen Banks; Blood specimen; Brain; Censuses; Cerebrospinal Fluid; Certification; Characteristics; Chemicals; Clinic; Clinic Visits; Clinical; Clinical Data; Clinical Sciences; Cognition Disorders; Communities; Data; Data Coordinating Center; Diagnosis; Elderly; Ensure; Equipment and supply inventories; Evaluation; Frequencies; Future; Gender; Gene Expression; Goals; HIV; HIV Infections; HIV Seronegativity; HIV-associated neurocognitive disorder; Health; Human; Immunologics; Immunosuppression; Impairment; Individual; Information Management; Informed Consent; Investigation; Investigator-Initiated Research; Lead; Longitudinal cohort; Measurement; Measures; National NeuroAids Tissue Consortium; Neurologic; Neurologic Dysfunctions; Neurologic Examination; Neuropsychological Tests; Neuropsychology; Participant; Pathologic; Pathology; Patient Self-Report; Patients; Persons; Population; Procedures; Prognosis; Protocols documentation; Reaction Time; Reporting; Research; Research Personnel; Resources; Risk; Schedule; Site; Specimen; Spinal Puncture; Standardization; Structure; Substance abuse problem; Surveys; System; Testing; Texas; Time; Tissue Banks; Tissues; Training; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Viral; Viral Load result; Viral reservoir; Virus Replication; Visit; age related; base; clinical research site; clinically relevant; cohort; data resource; distributed data; gulf coast; high risk; human tissue; in vivo; innovation; latent HIV reservoir; mortality; neuroAIDS; neurocognitive disorder; neuropathology; older patient; operation; programs; quality assurance; recruit; repository; response; substance use; synergism; therapeutic target; tissue resource

Abstract The National NeuroAIDS Tissue Consortium (NNTC) is a collaborative tissue and data resourcing program in which the Texas NeuroAIDS Research Center (TNRC; B. Gelman, PI) has participated since inception in 1998. The NNTC's purpose is to collect and distribute critical clinical data and tissue specimens from longitudinally- tracked HIV-infected individuals at high risk for HIV-associated neurocognitive disorders (HAND), to support innovative and transformative investigator-initiated research in the NeuroAIDS community-at-large. The NNTC patient cohort is unique because it is the sole pathology-focused longitudinal cohort in the HIV field. The consortium has helped to heightened the relevancy of research overall in the field. Beyond supplying tissue specimens the TNRC provides researchers access to relevant in vivo biomarkers, viral loads, gene expression data, neuropathological changes, and associated HAND cognitive status. This enables clinical and basic science-level researchers to incorporate these critical measures into investigations of the mechanisms driving HAND, HIV-associated pathological effects of HIV infection, or potential HAND therapeutic targets. In past cycles the NNTC has supported hundreds of research reports and grant applications, and would continue to do that into the future. The broad aim of the current TNRC application is to continue the cooperative agreement with other Clinical sites and the NIH, to provide such resources derived from locally-recruited (Texan) HIV patients, and to focus this local resource to address changing and future resource needs of the NeuroAIDS community. The TNRC patient cohort will focus in the future on the aging of the HIV population in the USA, which could inform about how age influences HIV-associated neuropsychological and neurological dysfunction. TNRC will emphasize providing tissue specimens to define the characteristics of the latent HIV reservoirs in the deep body compartments of virally suppressed people. Application for continued support to operate the Texan NNTC clinic site addresses all aspects of the general operating procedures of the TNRC. We describe recruiting practices, neuropsychological evaluations, substance use surveys, neuromedical protocols, autopsy procedure, and specimen repository management. We present proposed strategies to contribute to consortium-wide goals and to obtain synergy with the other units of the NNTC. Continued operation of NNTC and the TNRC will have a lasting and positive impact on the search for remedies for HAND, CNS aging, CNS latent HIV reservoirs and many other HIV-associated pathological conditions.

摘要 国家神经艾滋病组织联盟（NNTC）是一个合作组织和数据资源计划， 德克萨斯神经艾滋病研究中心（TNRC; B. Gelman，PI）自1998年成立以来一直参与。 NNTC的目的是从纵向收集和分发关键临床数据和组织标本- 跟踪HIV相关神经认知障碍（HAND）高危HIV感染者，以支持 在NeuroAIDS社区中开展创新和变革性的研究。NNTC 患者队列是独特的，因为它是HIV领域唯一以病理学为重点的纵向队列。的 联合会帮助提高了该领域整体研究的相关性。除了提供组织 TNRC为研究人员提供了相关的体内生物标志物，病毒载量，基因表达 数据、神经病理学变化和相关的HAND认知状态。这使得临床和基础 科学水平的研究人员将这些关键措施纳入驱动机制的调查 HAND、HIV感染的HIV相关病理效应或潜在HAND治疗靶点。过去 NNTC已经支持了数百份研究报告和拨款申请，并将继续这样做 把它带到未来目前TNRC申请的主要目的是继续合作协议 与其他临床研究中心和NIH合作，提供来自当地招募（德克萨斯州）HIV的此类资源 病人，并集中这一当地资源，以解决不断变化的和未来的资源需求的神经艾滋病 社区TNRC患者队列将在未来关注美国艾滋病毒人口的老龄化， 这可以告诉我们年龄是如何影响HIV相关的神经心理和神经功能障碍的。 TNRC将强调提供组织标本，以确定潜伏的HIV储存库的特征， 病毒被抑制的人的身体深处。申请继续资助 德克萨斯州NNTC临床研究中心解决了TNRC一般操作程序的所有方面。我们描述 招募实践、神经心理学评估、物质使用调查、神经医学协议、尸检 程序和标本库管理。我们提出了拟议的战略， 实现集团范围内的目标，并与NNTC的其他单位取得协同作用。NNTC的继续运行 TNRC将对寻找HAND，CNS老化，CNS 潜伏的HIV储库和许多其它HIV相关的病理状况。