Understanding the interpersonal context of HIV/HCV risk within injecting dyads

了解注射二人组中 HIV/HCV 风险的人际背景

• 批准号: 8731562
• 负责人: Meghan D Morris
• 金额: $ 18.24万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8731562
• 关键词: AIDS prevention; Address; Alcohol or Other Drugs use; Applied Research; Attention; Automobile Driving; Award; Behavior; Cohort Studies; Complex; Data; Development; Dimensions; Drug usage; Drug user; Educational workshop; Epidemiologic Methods; Epidemiologist; Equation; Equipment; Ethics; Evaluation; Exogenous Factors; Foundations; Friends; Funding; Future; Gender; Gossypium; HIV; HIV risk; Hepatitis C; Hepatitis C Incidence; Hepatitis C virus; Heterogeneity; Individual; Injecting drug user; Injection of therapeutic agent; Intervention; Intravenous; Knowledge; Life; Measurement; Measures; Mediating; Mediation; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Modeling; National Institute of Drug Abuse; Pathway interactions; Pharmaceutical Preparations; Play; Population; Positioning Attribute; Prevention Research; Prevention approach; Prevention strategy; Process; Public Health; Reading; Reporting; Research; Research Activity; Research Infrastructure; Research Methodology; Research Personnel; Risk; Risk Behaviors; Risk Reduction; Role; Sampling; San Francisco; Science; Scientist; Sexual Transmission; Shares syringes; Site; Statistical Methods; Sum; Syringes; Techniques; Testing; Training; Training Activity; Trust; United States National Institutes of Health; Water; Work; base; behavior change; career; cohort; disease transmission; efficacy testing; experience; high risk; innovation; intimate behavior; member; novel; pathogen; protective effect; psychologic; public health relevance; risk perception; sex; skills; social; theories; therapy design; transmission process

Project Summary/Abstract The purpose of this Mentored Scientist Research Development Award (K01) is to provide the candidate with mentoring and research experiences that will promote her development as an independent public health researcher with particular methodological expertise in dyadic research methods. Objectives of the training are to develop knowledge and skills in: 1) relationship theory to understand interpersonal dynamics; 2) dyadic study methods including cohort and intervention design; 3) advanced statistical techniques for dyadic data; and 4) ethical conduct of research. Training activities will include didactic courses and specific workshops, directed reading and one-on-one tutorials with mentors, and applied research experience. The candidate will receive mentorship from a Training Committee of internationally renowned experts in the fields of socio-psychological relationship theory, dyadic methods, substance use research, and prevention science for substance using populations. The specific research aims of the proposed K01 are to: 1) measure interpersonal factors and examine their association with high-risk injecting behaviors at the dyad-level; 2) determine the mediating and moderating effects of interpersonal factors on the association between factors exogenous to the dyad and high-risk injecting behaviors; and 3) examine whether changes in levels of interpersonal factors predict high- risk injecting behavior. The research aims will be accomplished by collecting a combination of cross-sectional (n=300 pairs) and longitudinal (n=100 pairs) data from injecting dyads (pairs of individuals who inject drugs together) as part of a multi-site cohort study of HIV and hepatitis C incidence in injection drug users (InC3, PI: Page). The proposed K01 research activities leverage sponsor study infrastructure to pursue questions not posed by the sponsor study by collecting data on interpersonal factors from both members of injecting dyads. Research activities are innovative because they: (1) use a novel measurement scale for interpersonal factors; (2) use dyadic data collected from pairs of individuals who inject together; and (3) will inform dyad-based prevention strategies to reduce intravenous transmission of HIV. Findings from the proposed research will position the candidate to apply for an R34 award to develop, implement, and evaluated a dyad-based risk- reduction intervention targeting interpersonal dynamics within injecting-dyads. The findings generated under the R34 will allow the subsequent submission of an R01 to test the efficacy of a full random control trail for a dyad-based intervention targeting interpersonal factors. In sum, the K01 activities will develop the candidate into a successful independent researcher with a unique methodological skill-set which combines dyadic research methods with her foundation in qualitative and quantitative epidemiological methods.

项目概要/摘要 导师科学家研究发展奖（K01）的目的是为候选人提供 指导和研究经验将促进她作为独立公共卫生人员的发展 在二元研究方法方面具有特定方法论专业知识的研究员。培训的目标是 发展以下方面的知识和技能：1）关系理论，以了解人际动态； 2）二元的 研究方法，包括队列和干预设计； 3）二元数据的先进统计技术；和 4) 研究的道德行为。培训活动将包括教学课程和具体讲习班， 阅读和与导师一对一的辅导，以及应用研究经验。候选人将收到 由社会心理学领域国际知名专家组成的培训委员会提供指导 关系理论、二元方法、物质使用研究和物质使用预防科学 人口。拟议的 K01 的具体研究目标是：1）测量人际因素和 检查它们与二元层面的高风险注射行为的关联； 2）确定中介和 人际因素对二元组外源因素与人际因素之间关联的调节作用 高危注射行为； 3）检查人际因素水平的变化是否预示着高 风险注入行为。研究目标将通过收集横截面的组合来实现 来自注射二人组（注射毒品的个体对）（n=300 对）和纵向（n=100 对）数据 一起）作为注射吸毒者艾滋病毒和丙型肝炎发病率多中心队列研究的一部分（InC3，PI： 页）。拟议的 K01 研究活动利用赞助商研究基础设施来追求不属于以下问题的问题： 由申办者研究通过收集注射二人组双方成员的人际因素数据而提出。 研究活动具有创新性，因为它们：（1）使用一种新颖的人际因素测量量表； (2) 使用从一起注射的成对个体收集的二元数据； (3) 将通知基于二元的 减少艾滋病毒静脉传播的预防策略。拟议研究的结果将 使候选人能够申请 R34 奖项，以开发、实施和评估基于二元的风险- 针对注射二人组内人际动态的减少干预。根据以下结果得出的结果 R34 将允许随后提交 R01 来测试完全随机对照试验的功效 针对人际因素的基于二元的干预。总而言之，K01活动将培养候选人 成为一名成功的独立研究员，拥有独特的方法论技能，结合了二元论 研究方法以定性和定量流行病学方法为基础。