Understanding the interpersonal context of HIV/HCV risk within injecting dyads

了解注射二人组中 HIV/HCV 风险的人际背景

• 批准号: 8885785
• 负责人: Meghan D Morris
• 金额: $ 18.27万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8885785
• 关键词: AIDS prevention; Address; Alcohol or Other Drugs use; Applied Research; Attention; Automobile Driving; Award; Behavior; Cohort Studies; Complex; Data; Development; Dimensions; Drug usage; Drug user; Educational workshop; Epidemiologic Methods; Epidemiologist; Equation; Equipment; Ethics; Evaluation; Exogenous Factors; Foundations; Friends; Funding; Future; Gender; Gossypium; HIV; HIV risk; Health; Hepatitis C; Hepatitis C Incidence; Hepatitis C virus; Heterogeneity; Individual; Injecting drug user; Injection of therapeutic agent; Intervention; Intravenous; Knowledge; Life; Measurement; Measures; Mediating; Mediation; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Modeling; National Institute of Drug Abuse; Pathway interactions; Pharmaceutical Preparations; Play; Population; Positioning Attribute; Prevention Research; Prevention approach; Prevention strategy; Process; Public Health; Reading; Reporting; Research; Research Activity; Research Infrastructure; Research Methodology; Research Personnel; Risk; Risk Behaviors; Risk Reduction; Role; Sampling; San Francisco; Science; Scientist; Shares syringes; Site; Statistical Methods; Sum; Syringes; Techniques; Testing; Training; Training Activity; Trust; United States National Institutes of Health; Water; Work; base; behavior change; career; cohort; disease transmission; efficacy testing; experience; high risk; innovation; intimate behavior; member; novel; pathogen; protective effect; psychologic; risk perception; sex; sexual HIV transmission; skills; social; theories; therapy design; transmission process

DESCRIPTION (provided by applicant): The purpose of this Mentored Scientist Research Development Award (K01) is to provide the candidate with mentoring and research experiences that will promote her development as an independent public health researcher with particular methodological expertise in dyadic research methods. Objectives of the training are to develop knowledge and skills in: 1) relationship theory to understand interpersonal dynamics; 2) dyadic study methods including cohort and intervention design; 3) advanced statistical techniques for dyadic data; and 4) ethical conduct of research. Training activities will include didactic courses and specific workshops, directed reading and one-on-one tutorials with mentors, and applied research experience. The candidate will receive mentorship from a Training Committee of internationally renowned experts in the fields of socio-psychological relationship theory, dyadic methods, substance use research, and prevention science for substance using populations. The specific research aims of the proposed K01 are to: 1) measure interpersonal factors and examine their association with high-risk injecting behaviors at the dyad-level; 2) determine the mediating and moderating effects of interpersonal factors on the association between factors exogenous to the dyad and high-risk injecting behaviors; and 3) examine whether changes in levels of interpersonal factors predict high- risk injecting behavior. The research aims will be accomplished by collecting a combination of cross-sectional (n=300 pairs) and longitudinal (n=100 pairs) data from injecting dyads (pairs of individuals who inject drugs together) as part of a multi-site cohort study of HIV and hepatitis C incidence in injection drug users (InC3, PI: Page). The proposed K01 research activities leverage sponsor study infrastructure to pursue questions not posed by the sponsor study by collecting data on interpersonal factors from both members of injecting dyads. Research activities are innovative because they: (1) use a novel measurement scale for interpersonal factors; (2) use dyadic data collected from pairs of individuals who inject together; and (3) will inform dyad-based prevention strategies to reduce intravenous transmission of HIV. Findings from the proposed research will position the candidate to apply for an R34 award to develop, implement, and evaluated a dyad-based risk- reduction intervention targeting interpersonal dynamics within injecting-dyads. The findings generated under the R34 will allow the subsequent submission of an R01 to test the efficacy of a full random control trail for a dyad-based intervention targeting interpersonal factors. In sum, the K01 activities will develop the candidate into a successful independent researcher with a unique methodological skill-set which combines dyadic research methods with her foundation in qualitative and quantitative epidemiological methods.

描述（由申请人提供）：这一指导的科学家研究发展奖（K01）的目的是为候选人提供指导和研究经验，这些经验将促进她作为独立公共卫生研究人员的发展，并具有二元研究方法中特定的方法论专业知识。培训的目标是在以下方面发展知识和技能：1）关系理论以了解人际动态； 2）包括队列和干预设计在内的二元研究方法； 3）二元数据的高级统计技术； 4）研究的道德行为。培训活动将包括教学课程和特定的讲习班，有导师的定向阅读以及带有导师的一对一教程以及应用研究经验。候选人将获得社会心理关系理论，二元方法，药物使用研究和预防科学的国际知名专家培训委员会的指导委员会。提出的K01的具体研究目的是：1）测量人际因素并检查其与二元级别的高风险注射行为的关联； 2）确定人际因素对二元组和高风险注射行为的因素之间关联的介导和调节作用； 3）检查人际关系因素水平的变化是否预测了高风险注射行为。该研究的目的将通过收集横截面（n = 300对）和纵向（n = 100对）数据的组合来实现，从注射二元组（对成对的个体将药物一起注射在一起）作为一部分 注射吸毒者的艾滋病毒和丙型肝炎发病率的多站点队列研究（inc3，pi：page）。拟议的K01研究活动利用赞助商研究基础设施来提出赞助商研究而不是通过收集注射二元组成员的人际关系因素的数据而提出的问题。研究活动具有创新性，因为它们：（1）使用新颖的测量量表来实现人际因素； （2）使用从一起注射的个体成对收集的二元数据； （3）将告知基于二元的预防策略，以减少艾滋病毒的静脉传播。拟议研究的发现将使候选人申请申请R34奖励，以开发，实施和评估针对注射dyads内部人际动态的基于二元的风险降低干预措施。在R34下产生的发现将允许随后提交R01，以测试完全随机控制跟踪的功效，以针对针对人际关系的基于二元组的干预措施。总而言之，K01活动将通过独特的方法学技能设定将候选人发展为成功的独立研究人员，该方法将二元研究方法与她的基础结合在一起，以定性和定量的流行病学方法。