BIOSTATISTICS/BIOINFORMATICS CORE

生物统计学/生物信息学核心

• 批准号: 8729250
• 负责人: STEPHANIE R LAND
• 金额: $ 24.58万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8729250
• 关键词: Area; Bioinformatics; Biological Markers; Biometry; Blood Banks; Cancer Patient; Clinical; Clinical Data; Clinical Trials; Communication; Comprehensive Cancer Center; Confidentiality of Patient Information; Data; Data Analyses; Data Collection; Databases; Development; Disease; Ensure; Evaluation; Funding; Goals; In Vitro; Institution; Laboratories; Lead; Lung; Malignant neoplasm of lung; Manuscripts; Modeling; Participant; Patients; Pilot Projects; Progress Reports; Reproduction spores; Research; Research Design; Research Personnel; Research Project Grants; Resources; Sampling; Specimen; Techniques; Texas; Tissue Banking; Tissue Banks; Tissues; Translations; Universities; University of Pittsburgh Cancer Institute; Validation; Work; Writing; abstracting; base; career; data sharing; design; experience; improved; in vivo; meetings; member; research study; response

This Core brings together biostatisticians and bioinformaticians who are experienced in the scientific areas covered by the SPORE and who are already close collaborators with SPORE lead investigators. The Specific Aims of the Biostatistics and Bioinformatics Core are 1. To contribute statistical expertise to the design and perform the analysis of data from in vitro and in vivo experiments and clinical trials proposed in the SPORE, in developmental research projects, and by career trainees funded by this SPORE; 2. To work with the Project and Core investigators, including the Clinical Core and Tissue and Blood Bank Core, to ensure that data collection and database development are appropriate for the requisite statistical analyses while ensuring patient confidentiality and the integrity of all SPORE tissue banks; and to provide PLuSS and other SPORE data for approved research by local researchers and collaborators in other institutions; 3. To collaborate with investigators in writing and preparing progress reports, abstracts, manuscripts, and presentations, and 4. To conduct methodological research motivated by the challenges of SPORE research. To achieve these aims. Core members are fully integrated into the research teams for each study. They maintain frequent communication both within the Core and with other SPORE researchers. The projects of the University of Pittsburgh Lung SPORE are designed to share information and resources. For example, several projects will make use of the same sets of subjects (retrospective UPCI lung cancer patients and PLuSS participants). In addition, the Pittsburgh SPORE has proposed to share data and patient samples with the UCLA Jonnson Comprehensive Cancer Center and the University of Texas - Southwestern. The Core will ensure that resources are used efficiently, and each project builds on the information gained from other Pittsburgh SPORE projects and other institutions. Core D will facilitate the smooth transfer of techniques, data, and patient tissues among projects and institutions, while ensuring patient confidentiality.

该核心汇集了在科学领域经验丰富的生物统计学家和生物信息学家 由 SPORE 覆盖，并且已经是 SPORE 首席调查员的密切合作者。这 生物统计学和生物信息学核心的具体目标是 1. 为生物统计和生物信息学贡献统计专业知识 设计并分析体外和体内实验以及临床试验中提出的数据 SPORE，在发展研究项目中，以及由该 SPORE 资助的职业实习生； 2. 上班 与项目和核心研究人员（包括临床核心、组织和血库核心）合作， 确保数据收集和数据库开发适合必要的统计分析 同时确保患者的机密性和所有 SPORE 组织库的完整性；并提供 PLuSS 和 由当地研究人员和其他机构的合作者批准的研究的其他 SPORE 数据； 3. 到 与研究人员合作撰写和准备进度报告、摘要、手稿和 演讲，以及 4. 以 SPORE 研究的挑战为动力进行方法论研究。 为了实现这些目标。核心成员完全融入每项研究的研究团队。他们 在核心内部以及与其他 SPORE 研究人员保持频繁的沟通。的项目 匹兹堡大学 Lung SPORE 旨在共享信息和资源。例如， 几个项目将使用相同的受试者组（回顾性 UPCI 肺癌患者和 PLuSS 参与者）。此外，匹兹堡 SPORE 还提议共享数据和患者样本 与加州大学洛杉矶分校琼森综合癌症中心和德克萨斯大学西南分校合作。这 核心将确保资源得到有效利用，每个项目都建立在从 其他匹兹堡 SPORE 项目和其他机构。 Core D将促进顺利转移 项目和机构之间的技术、数据和患者组织，同时确保患者机密。