Transport Phenomena in the Lymphatic System

淋巴系统中的运输现象

• 批准号: 8744545
• 负责人: JAMES E MOORE
• 金额: $ 64.19万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8744545
• 关键词: Affect; Animal Model; Antigens; Back; Behavior; Bibliography; Blood Circulation; Businesses; Caliber; Cancer Patient; Cardiovascular Diseases; Cause of Death; Cell physiology; Cells; Characteristics; Communication; Complex; Computer Simulation; Contracts; Coupled; Data; Development; Disease; Elements; Exhibits; Fluid Balance; Foreign Bodies; Funding; Goals; Health; High Endothelial Venule; Human; Immune; Immune system; Immunity; Inflammation; Injury; Intercellular Fluid; Laws; Leukocytes; Liquid substance; Lymph; Lymph Node Dissections; Lymphatic; Lymphatic System; Lymphatic vessel; Lymphedema; Malignant Neoplasms; Mechanics; Modeling; Movement; Muscle; Muscle Cells; Neoplasm Metastasis; Obesity; Operative Surgical Procedures; Patients; Performance; Physiological; Physiology; Positioning Attribute; Procedures; Process; Publications; Pump; Research; Resistance; Resolution; Role; Route; Series; Site; Smooth Muscle; Solid; Striated Muscles; Structure; System; Tissues; Trauma; Venous system; Work; antigen processing; base; cell behavior; disability; electric impedance; improved; insight; lymph nodes; lymphatic circulation; model development; multi-scale modeling; neoplastic cell; network models; pathogen; physical model; physical property; pressure; prevent; public health relevance; research study; skills

DESCRIPTION (provided by applicant): The lymphatic system performs many crucial functions in health, gathering approximately 6 liters/day of interstitial fluid and returning it tothe venous system. As this fluid is filtered, undesirable elements such as tumor cells and foreign pathogens are normally destroyed in lymph nodes. This system is also part of the primary transport mechanism for the immune system. Lymphedema, a debilitating disease, for which there is no known cure, affects a large number of cancer patients who have undergone lymph node dissection, as well as trauma victims. The lymphatic system is also the major transport route for metastases of the most deadly cancers. Understanding and modeling the transport of lymph remains a challenge. Much of the pumping work comes from the contraction of lymphatic vessel smooth muscle, with valves preventing backflow. We are developing a multi-scale network model of the lymphatic circulation based on a combination of physical laws, material descriptions, and models of active cellular processes. Goals of this iterative model development process are to gain a better understanding of normal lymphatic function as well as multiple diseases.

描述（由申请人提供）：淋巴系统在健康中执行许多关键功能，收集约6升/天的组织液并将其返回静脉系统。当这种液体被过滤时，诸如肿瘤细胞和外来病原体等不需要的元素通常在淋巴结中被破坏。该系统也是免疫系统的主要运输机制的一部分。淋巴水肿是一种使人衰弱的疾病，目前还没有治愈方法，影响了大量接受淋巴结清扫术的癌症患者以及创伤患者。淋巴系统也是最致命癌症转移的主要运输途径。理解和模拟淋巴的运输仍然是一个挑战。大部分泵送工作来自淋巴管平滑肌的收缩，瓣膜防止回流。我们正在开发一个多尺度的淋巴循环网络模型的基础上结合物理定律，材料的描述，和活跃的细胞过程的模型。这种迭代模型开发过程的目标是更好地了解正常淋巴功能以及多种疾病。