Lymphatic Fluid Flow Modeling with Active Network Components

使用主动网络组件进行淋巴液流动建模

• 批准号: 7687313
• 负责人: JAMES E MOORE
• 金额: $ 68.91万
• 依托单位: TEXAS ENGINEERING EXPERIMENT STATION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7687313
• 关键词: Accounting; Affect; Blood Vessels; Caliber; Cancer Patient; Cell physiology; Cells; Characteristics; Chiroptera; Code; Communication; Data; Development; Disease; Doctor of Philosophy; Edema; Elements; Equilibrium; Event; Excision; Extensible Markup Language; Goals; Health; Immune system; Individual; Intercellular Fluid; Laws; Link; Liquid substance; Literature; Location; Lymph; Lymph Node Dissections; Lymphatic; Lymphatic Endothelial Cells; Lymphatic System; Lymphatic vessel; Lymphedema; Malignant Neoplasms; Mesentery; Modeling; Muscle; Neoplasm Metastasis; Operative Surgical Procedures; Organ; Outcome; Pathologic; Pathology; Performance; Principal Investigator; Process; Proteins; Publications; Pump; Rattus; Research; Route; Running; Signal Transduction; Simulate; Smooth Muscle; Smooth Muscle Myocytes; System; Time; Tissues; Trauma; Venous system; Wing; Work; base; design; fluid flow; insight; lymph flow; lymph nodes; lymphatic circulation; model development; neoplastic cell; network models; pathogen; pressure; prevent; public health relevance; research study; response; solute; three-dimensional modeling

DESCRIPTION (provided by applicant): Summary The lymphatic system performs many crucial functions in health, gathering approximately 4 liters/day of interstitial fluid and returning it to the venous system. As this fluid is filtered, undesirable elements such as tumor cells and foreign pathogens are normally destroyed in lymph nodes. This system is also part of the primary transport mechanism for the immune system. Lymphedema, a debilitating disease for which there is no known cure, affects a large number of cancer patients who have undergone lymph node dissection as well as trauma victims. The lymphatic system is also the major transport route for metastases of the most deadly cancers. Understanding and modeling the transport of lymph remains a challenge. Much of the pumping work comes from the contraction of lymphatic vessel smooth muscle, with valves preventing backflow. We propose to develop a multi-scale network model of the lymphatic circulation based on a combination of physical laws, material descriptions, and models of active cellular processes. Goals of this iterative model development process are to gain a better understanding of normal lymphatic function as well as multiple diseases. PUBLIC HEALTH RELEVANCE: Narrative The lymphatic system is directly involved in Lymhedema, an incurable condition that affects a large percentage of cancer patients who have undergone surgery. It is also involved in the spread of cancer, serving as the principal route of distribution for cancer metastases.

描述（由申请人提供）： 摘要 淋巴系统在健康中发挥着许多重要的功能，每天收集大约 4 升的间质液并将其返回静脉系统。当这种液体被过滤时，肿瘤细胞和外来病原体等不需要的元素通常会在淋巴结中被破坏。该系统也是免疫系统主要运输机制的一部分。淋巴水肿是一种无法治愈的使人衰弱的疾病，影响着大量接受淋巴结清扫术的癌症患者以及创伤受害者。淋巴系统也是最致命癌症转移的主要运输途径。了解和模拟淋巴的运输仍然是一个挑战。大部分泵送工作来自淋巴管平滑肌的收缩，阀门防止回流。我们建议基于物理定律、材料描述和活跃细胞过程模型的组合，开发淋巴循环的多尺度网络模型。该迭代模型开发过程的目标是更好地了解正常淋巴功能以及多种疾病。公共卫生相关性：叙述 淋巴系统直接涉及淋巴水肿，这是一种无法治愈的疾病，影响着大部分接受手术的癌症患者。它还参与癌症的扩散，是癌症转移的主要分布途径。