Lymphatic Fluid Flow Modeling with Active Network Components

描述(申请人提供)：淋巴系统在健康中发挥着许多重要的功能，每天收集大约4升间质液体，并将其返回静脉系统。当这种液体被过滤时，肿瘤细胞和外来病原体等不良元素通常会在淋巴结内被破坏。这个系统也是免疫系统主要运输机制的一部分。淋巴水肿是一种使人衰弱的疾病，目前还没有已知的治疗方法，它影响着大量接受过淋巴清扫的癌症患者和创伤受害者。淋巴系统也是最致命的癌症转移的主要运输途径。对淋巴运输的理解和建模仍然是一个挑战。大部分泵送工作来自淋巴管平滑肌的收缩，瓣膜可以防止回流。我们建议开发一个基于物理定律、材料描述和活跃细胞过程模型的多尺度网络淋巴循环模型。这个迭代模型开发过程的目标是更好地了解正常淋巴功能以及多种疾病。公共卫生相关性：淋巴系统与淋巴系统直接相关，淋巴水肿是一种无法治愈的疾病，影响到大部分接受过手术的癌症患者。它还参与了癌症的扩散，是癌症转移的主要分布途径。

DESCRIPTION (provided by applicant): Summary The lymphatic system performs many crucial functions in health, gathering approximately 4 liters/day of interstitial fluid and returning it to the venous system. As this fluid is filtered, undesirable elements such as tumor cells and foreign pathogens are normally destroyed in lymph nodes. This system is also part of the primary transport mechanism for the immune system. Lymphedema, a debilitating disease for which there is no known cure, affects a large number of cancer patients who have undergone lymph node dissection as well as trauma victims. The lymphatic system is also the major transport route for metastases of the most deadly cancers. Understanding and modeling the transport of lymph remains a challenge. Much of the pumping work comes from the contraction of lymphatic vessel smooth muscle, with valves preventing backflow. We propose to develop a multi-scale network model of the lymphatic circulation based on a combination of physical laws, material descriptions, and models of active cellular processes. Goals of this iterative model development process are to gain a better understanding of normal lymphatic function as well as multiple diseases. PUBLIC HEALTH RELEVANCE: Narrative The lymphatic system is directly involved in Lymhedema, an incurable condition that affects a large percentage of cancer patients who have undergone surgery. It is also involved in the spread of cancer, serving as the principal route of distribution for cancer metastases.