Epstein Barr virus antisense transcription

描述：B细胞的重新激活对EB病毒(EBV)的生命周期至关重要，它 在放大艾滋病患者的病毒滴度方面起到了作用。被认为是EBV基因的全套 参与病毒复制的基因主要由大约80-90个蛋白质编码基因组成。这些病毒蛋白在病毒生产中扮演着非常不同的角色，包括在DNA复制、RNA转录、分子运输、病毒粒子组装、病毒出口、宿主关闭等方面的角色。更不用说作为病毒组件的角色了；这两个组件形成了病毒结构，以及那些参与诱导新感染后立即产生快速信号反应的组件。我们假设，除了这组已知的蛋白质编码基因外，EBV还编码一组以前不为人知的长非编码转录本，最终将发现它们在病毒复制中发挥着同样不同的功能。从概念上讲，这将是重要的，因为它将改变纹理和我们大多数人如何可视化重新激活过程的细节。从实际的角度来看，它将 给我们一类新的分子靶点，可能会提供应用替代治疗方法来对抗EBV。

DESCRIPTION: Reactivation in B-cells is critical for the Epstein Barr virus (EBV) life cycle and it plays a role in amplifying viral titers in AIDS patients. The repertoire of EBV genes thought to be involved in viral replication consists primarily of approximately 80-90 protein-coding genes. These viral proteins play very diverse roles in virus production including roles in DNA replication, RNA transcription, molecular trafficking, virion assembly, viral egress, host shut-off etc. This is not to mention roles as viron components; both components that form the virus architecture as well as those that are involved in inducing the rapid signaling responses immediately following new infection. We hypothesize that in addition to this group of known protein coding genes, EBV encodes a previously unappreciated group of long non-coding transcripts that will ultimately be found to play an equally diverse set of functions in virus replication. Conceptually this would be important because it would change the texture and the details of how most of us visualize the reactivation process. From a practical standpoint, it would give us a new class of molecular targets that may offer the application of alternative therapeutic approaches against EBV.