Epstein Barr virus antisense transcription

Epstein Barr病毒反义转录

• 批准号: 9206435
• 负责人: ERIK K FLEMINGTON
• 金额: $ 37.63万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-18 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9206435
• 关键词: Acquired Immunodeficiency Syndrome; Architecture; B-Lymphocytes; Code; Complex; DNA biosynthesis; DNA sequencing; Fractionation; Genes; Genetic Transcription; Human Herpesvirus 4; Immune Targeting; Immune system; Infection; Life Cycle Stages; Lymphoma; MicroRNAs; Modeling; Molecular; Molecular Target; Northern Blotting; Oncogenic; Pathogenicity; Patients; Phase; Play; Process; Production; Property; Proteins; RNA; Role; Signal Transduction; Texture; Therapeutic; Time; Transcript; Untranslated RNA; Viral; Viral Proteins; Virion; Virus; Virus Replication; public health relevance; response; tool; trafficking; viron

DESCRIPTION: Reactivation in B-cells is critical for the Epstein Barr virus (EBV) life cycle and it plays a role in amplifying viral titers in AIDS patients. The repertoire of EBV genes thought to be involved in viral replication consists primarily of approximately 80-90 protein-coding genes. These viral proteins play very diverse roles in virus production including roles in DNA replication, RNA transcription, molecular trafficking, virion assembly, viral egress, host shut-off etc. This is not to mention roles as viron components; both components that form the virus architecture as well as those that are involved in inducing the rapid signaling responses immediately following new infection. We hypothesize that in addition to this group of known protein coding genes, EBV encodes a previously unappreciated group of long non-coding transcripts that will ultimately be found to play an equally diverse set of functions in virus replication. Conceptually this would be important because it would change the texture and the details of how most of us visualize the reactivation process. From a practical standpoint, it would give us a new class of molecular targets that may offer the application of alternative therapeutic approaches against EBV.

描述：B细胞中的再活化对爱泼斯坦巴尔病毒（EBV）的生命周期至关重要， 在艾滋病患者体内起着放大病毒滴度的作用。EB病毒基因库被认为是 参与病毒复制的基因主要由大约80-90个蛋白质编码基因组成。这些病毒蛋白质在病毒生产中发挥着非常不同的作用，包括DNA复制、RNA转录、分子运输、病毒体组装、病毒外出、宿主关闭等。更不用说作为病毒体组分的作用了;这两种组分形成病毒结构，以及那些参与诱导新感染后立即发生的快速信号反应的组分。我们假设，除了这组已知的蛋白质编码基因，EBV编码一个以前不受重视的长非编码转录本，最终将被发现在病毒复制中发挥同样多样的功能。从概念上讲，这是很重要的，因为它会改变我们大多数人如何想象重新激活过程的结构和细节。从实际的角度来看， 为我们提供了一类新的分子靶点，可能为针对EBV的替代治疗方法提供应用。