Chicago Stroke Trials Consortium

芝加哥中风试验联盟

• 批准号: 9756475
• 负责人: Shyam Prabhakaran
• 金额: $ 31.48万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756475
• 关键词: Academic Medical Centers; Acute; Adult; Agreement; Area; Award; Blood Vessels; Brain hemorrhage; Caring; Cause of Death; Chicago; Child; Clinical; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Community Hospitals; County; Development; Disease; Education; Elderly; Emergency Care; Emergency Medicine; Enrollment; Ensure; Environment; Faculty; Fostering; Funding; Future; Geography; Growth and Development function; Hospitals; Illinois; Individual; Industry; Infrastructure; Institutes; Institutional Review Boards; International; Intervention; Lead; Leadership; Medical Research; Medical center; Mentors; Mentorship; National Institute of Neurological Disorders and Stroke; Network Infrastructure; Neurology; Neurosciences; Outcome; Patient Recruitments; Patients; Pediatric Hospitals; Pediatric Neurology; Peer Review; Population; Prevention; Prevention approach; Prevention trial; Principal Investigator; Procedures; Process; Recording of previous events; Recovery; Rehabilitation therapy; Research; Research Personnel; Resources; Role; Sample Size; Site; Societies; Standardization; Stroke; Stroke prevention; System; Time; Training; Training Programs; Translational Research; Translations; United States; United States National Institutes of Health; Universities; Veterans; Wisconsin; Work; acute stroke; aging population; base; career; clinical biomarkers; cohesion; cooking; cost; data management; disability; effective therapy; experience; improved; innovation; medical schools; metropolitan; multidisciplinary; neuroimaging; neurological rehabilitation; neuroprotection; neurosurgery; novel strategies; patient population; phase III trial; programs; recruit; response; statistics; stroke patient; stroke rehabilitation; stroke therapy; stroke trials; telerehabilitation; validation studies; working group

Stroke is a leading cause of death and disability in the United States. Despite scientific and technological advances, there has been limited translation into clinical outcome benefits for stroke patients. Since 2013, a cohesive and integrated Stroke Trials Network has been working to develop breakthrough stroke treatments with an emphasis on rapid execution of clinical trials with sufficient sample sizes, robust enrollment, timely completion, and rigorous and uniform infrastructure across sites. This application is in response to the recent NINDS request for Regional Coordinating Stroke Centers (RCC) in the NINDS Stroke Trials Network (PAR-17-276). The Chicago Stroke Trials Consortium (CSTC) led by the RCC at Northwestern University (NU) has been an integral part of the NIH StrokeNet. In this renewal application, we expand our network to include 12 centers in the Chicago and Milwaukee metropolitan areas: Northwestern Memorial Hospital, Lurie Children's Hospital, Shirley Ryan Ability Lab, (all part of NU's McGaw Medical Center), the University of Chicago, Rush University Medical Center, Loyola University Chicago, University of Illinois at Chicago, Medical College of Wisconsin, the Hektoen Institute for Medical Research/John H. Stroger, Jr. Hospital of Cook County, Central Dupage Hospital, Northwest Community Hospital, and Edward Hines, Jr. VA Hospital. We have enlisted institutional support including agreements to utilize a federated institutional review board process (central IRB) and master trial agreements to ensure rapid implementation of future trials from each of our participating sites. The RCC aims to combine resources, diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients spanning from children to elderly and from acute treatment to rehabilitation. The CSTC will participate in acute stroke, rehabilitation, and prevention trials, and has expertise from investigators in vascular neurology, neurosurgery, neurocritical care, neuroradiology, interventional neuroradiology, neurorehabilitation, pediatric neurology, and emergency medicine. The amassed investigators have backgrounds in all aspects of stroke research and leadership roles in many recently completed and ongoing NIH and industry-sponsored trials. The consortium has a combined geographic referral base encompassing almost 10 million people and has a history of collaboration in clinical and scientific endeavors. Drawing from the vast geographic reach of our hospitals, their resources and investigators, and substantial contributions to StrokeNet during the initial award period, the CSTC is uniquely qualified to continue to deliver a diverse stroke patient population, provide consolidated multi-disciplinary and multi-institutional expertise and leadership for StrokeNet trials, and ensure mentoring for trainees and junior faculty seeking academic careers in stroke.

在美国，中风是导致死亡和残疾的主要原因。尽管科学和技术 随着研究的进展，将其转化为对中风患者的临床结果益处的研究有限。自2013年以来， 具有凝聚力和综合性的中风试验网络一直致力于开发突破性的中风治疗方法 强调快速执行临床试验，具有足够的样本量、稳健的登记、及时 完成，以及跨站点的严格和统一的基础设施。 此应用程序是对最近NINDS关于区域协调卒中中心的请求的响应 (RCC)在NINDS卒中试验网络(PAR-17-276)中。芝加哥卒中试验联盟(CSTC)领导 西北大学(NU)的RCC一直是NIH StrokeNet的组成部分。在这次更新中 应用程序，我们将我们的网络扩展到芝加哥和密尔沃基大都市区的12个中心： 西北纪念医院，Lurie儿童医院，Shirley Ryan能力实验室，(都是NU的McGaw的一部分 医学中心)，芝加哥大学，拉什大学医学中心，洛约拉大学芝加哥， 伊利诺伊大学芝加哥分校，威斯康星医学院，Hektoen医学院 研究/小约翰·H·斯特罗格库克县医院，西北社区中心杜邦医院 医院，和小爱德华·海因斯。退伍军人医院。我们已经争取到机构支持，包括达成协议 利用联合机构审查委员会流程(中央IRB)和主要试验协议，确保快速 从我们的每个参与站点实施未来的试验。RCC的目标是整合资源， 拥有中风专业知识的多元化教职员工，并可接触到来自不同种族的中风患者 从儿童到老年人，从急性治疗到康复。CSTC将参加急性中风， 康复和预防试验，并拥有血管神经学、神经外科、 神经危重护理、神经放射学、介入神经放射学、神经康复、儿科神经病学 急救医学。聚集的研究人员在中风研究的各个方面都有背景， 在许多最近完成和正在进行的NIH和行业赞助的试验中发挥领导作用。该财团 拥有一个涵盖近1000万人的综合地理推荐基础，并拥有 在临床和科学工作中的合作。从我们医院广阔的地理范围来看， 他们的资源和调查人员，以及在最初获奖期间对StrokeNet的重大贡献， CSTC是唯一有资格继续为多样化的中风患者群体提供综合服务的机构 StrokeNet试验的多学科和多机构专业知识和领导能力，并确保指导 寻求中风学术生涯的实习生和初级教员。