Stroke Trials Network - Regional Coordinating Stroke Centers

描述(申请人提供)：在美国，中风是导致死亡和残疾的主要原因，因此非常需要有效的治疗方法。尽管科学和技术取得了进步，但转化为中风患者临床结果益处的研究有限。正如最近的几项试验所表明的那样，开发突破性中风治疗方法的一个关键因素是快速执行临床试验，这些试验具有足够的样本量、稳健的登记、及时完成以及跨地点严格和统一的基础设施。 此应用程序是为了响应NINDS最近在NINDS卒中试验网络(RFA-NS-13-011)中建立区域协调卒中中心(RCC)的请求。由西北大学(NU)RCC领导的芝加哥卒中试验联盟(CSTC)是由芝加哥大都市区的7个中心组成的合作网络：西北纪念医院(NMH)、Lurie儿童医院(LCH)、芝加哥康复研究所(RIC)[都是NU麦高医学中心的一部分]、芝加哥大学(UC)、拉什大学医学中心(RUMC)、芝加哥洛约拉大学(LUMC)和小约翰·H·斯特罗格/Hektoen医学研究所。库克县医院(CCH)。我们已经争取了机构支持，包括同意利用联邦机构审查委员会程序(中央IRB)和主要试验协议，以确保从我们每个参与地点迅速实施未来的试验。RCC的目标是将资源、具有中风专业知识的不同教师以及接触到从儿童到老年人以及从急性治疗到康复的多民族中风患者群体结合起来。CSTC将参与急性中风、康复和预防试验，并拥有血管神经学、神经外科、神经危重护理、神经放射学、介入性神经放射学、神经康复、儿科神经病学和急诊医学方面的研究人员的专业知识。聚集的研究人员在中风研究的方方面面都有背景，并在许多最近完成和正在进行的NIH和行业赞助的试验中担任领导角色。该联盟拥有一个涵盖近1000万人的综合地理转诊基础，并在临床和科学努力方面有合作的历史。凭借我们医院广阔的地理范围及其资源和研究人员，CSTC是唯一有资格为多样化的中风患者群体提供服务的机构，为网络试验提供综合的多学科和多机构的专业知识和领导能力，并确保为寻求中风学术生涯的实习生和初级教员提供指导。

DESCRIPTION (provided by applicant): There is a great need for effective treatments in stroke as the disease is a leading cause of death and disability in the United States. Despite scientific and technological advances, there has been limited translation into clinical outcome benefits for stroke patients. As several recent trials illustrate, a key factor in developing breakthrough stroke treatments is the rapid execution of clinical trials with sufficient sample sizes, robust enrollment, timely completion, and rigorous and uniform infrastructure across sites. This application is in response to the recent NINDS request for Regional Coordinating Stroke Centers (RCC) in the NINDS Stroke Trials Network (RFA-NS-13-011). The Chicago Stroke Trials Consortium (CSTC) led by the RCC at Northwestern University (NU) is a collaborative network of 7 centers in the Chicago metropolitan area: Northwestern Memorial Hospital (NMH), Lurie Children's Hospital (LCH), Rehabilitation Institute of Chicago (RIC) [all part of NU's McGaw Medical Center], the University of Chicago (UC), Rush University Medical Center (RUMC), Loyola University Chicago (LUMC), and the Hektoen Institute for Medical Research/John H. Stroger, Jr. Hospital of Cook County (CCH). We have enlisted institutional support including agreements to utilize a federated institutional review board process (central IRB) and master trial agreements to ensure rapid implementation of future trials from each of our participating sites. The RCC aims to combine resources, diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients spanning from children to elderly and from acute treatment to rehabilitation. The CSTC will participate in acute stroke, rehabilitation, and prevention trials, and has expertise from investigators in vascular neurology, neurosurgery, neurocritical care, neuroradiology, interventional neuroradiology, neurorehabilitation, pediatric neurology, and emergency medicine. The amassed investigators have backgrounds in all aspects of stroke research and leadership roles in many recently completed and ongoing NIH and industry-sponsored trials. The consortium has a combined geographic referral base encompassing almost 10 million people and has a history of collaboration in clinical and scientific endeavors. Drawing from the vast geographic reach of our hospitals and their resources and investigators, the CSTC is uniquely qualified to deliver a diverse stroke patient population, provide consolidated multi-disciplinary and multi-institutional expertise and leadership for network trials, and ensure mentoring for trainees and junior faculty seeking academic careers in stroke.