Stroke Trials Network - Regional Coordinating Stroke Centers

中风试验网络 - 区域中风协调中心

• 批准号: 8739698
• 负责人: Shyam Prabhakaran
• 金额: $ 38.37万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739698
• 关键词: Academic Medical Centers; Acute; Adult; Aging; Agreement; Area; Biological Markers; Blood Vessels; Brain hemorrhage; Caring; Cause of Death; Cessation of life; Chicago; Child; Clinical; Clinical Trials; Collaborations; Conduct Clinical Trials; County; Data; Development; Disease; Elderly; Emergency Medicine; Emergency treatment; Enrollment; Ensure; Environment; Faculty; Fellowship; Fostering; Funding; Future; Growth and Development function; Hospitals; Individual; Industry; Institutes; Institutional Review Boards; International; Ischemic Stroke; Leadership; Medical Research; Mentors; Mentorship; Neurological emergencies; Neurology; Neurorehabilitation; Neurosciences; Outcome; Outcomes Research; Patient Recruitments; Patients; Pediatric Hospitals; Pediatric Neurology; Phase; Phase III Clinical Trials; Plasminogen Activator; Population; Prevention; Procedures; Process; Qualifying; Recording of previous events; Recruitment Activity; Registries; Rehabilitation therapy; Research; Research Infrastructure; Research Methodology; Research Personnel; Resources; Role; Sample Size; Science; Seminal; Site; Societies; Stroke; System; Testing; Training Programs; Translations; United States; United States National Institutes of Health; Universities; Work; acute stroke; arm; base; career; cooking; cost; data management; disability; effective therapy; improved; medical schools; metropolitan; nervous system disorder; neurosurgery; patient population; public health relevance; response; stroke rehabilitation; treatment trial

DESCRIPTION (provided by applicant): There is a great need for effective treatments in stroke as the disease is a leading cause of death and disability in the United States. Despite scientific and technological advances, there has been limited translation into clinical outcome benefits for stroke patients. As several recent trials illustrate, a key factor in developing breakthrough stroke treatments is the rapid execution of clinical trials with sufficient sample sizes, robust enrollment, timely completion, and rigorous and uniform infrastructure across sites. This application is in response to the recent NINDS request for Regional Coordinating Stroke Centers (RCC) in the NINDS Stroke Trials Network (RFA-NS-13-011). The Chicago Stroke Trials Consortium (CSTC) led by the RCC at Northwestern University (NU) is a collaborative network of 7 centers in the Chicago metropolitan area: Northwestern Memorial Hospital (NMH), Lurie Children's Hospital (LCH), Rehabilitation Institute of Chicago (RIC) [all part of NU's McGaw Medical Center], the University of Chicago (UC), Rush University Medical Center (RUMC), Loyola University Chicago (LUMC), and the Hektoen Institute for Medical Research/John H. Stroger, Jr. Hospital of Cook County (CCH). We have enlisted institutional support including agreements to utilize a federated institutional review board process (central IRB) and master trial agreements to ensure rapid implementation of future trials from each of our participating sites. The RCC aims to combine resources, diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients spanning from children to elderly and from acute treatment to rehabilitation. The CSTC will participate in acute stroke, rehabilitation, and prevention trials, and has expertise from investigators in vascular neurology, neurosurgery, neurocritical care, neuroradiology, interventional neuroradiology, neurorehabilitation, pediatric neurology, and emergency medicine. The amassed investigators have backgrounds in all aspects of stroke research and leadership roles in many recently completed and ongoing NIH and industry-sponsored trials. The consortium has a combined geographic referral base encompassing almost 10 million people and has a history of collaboration in clinical and scientific endeavors. Drawing from the vast geographic reach of our hospitals and their resources and investigators, the CSTC is uniquely qualified to deliver a diverse stroke patient population, provide consolidated multi-disciplinary and multi-institutional expertise and leadership for network trials, and ensure mentoring for trainees and junior faculty seeking academic careers in stroke.

描述（由申请人提供）：由于中风是美国死亡和残疾的主要原因，因此对有效治疗中风的需求很大。尽管科学技术取得了进步，但对中风患者的临床疗效的转化有限。正如最近的几项试验所表明的那样，开发突破性中风治疗的关键因素是临床试验的快速执行，样本量足够，报名人数充足，及时完成，以及各地点严格统一的基础设施。