Stroke Trials Network - Regional Coordinating Stroke Centers

中风试验网络 - 区域中风协调中心

• 批准号: 8895098
• 负责人: Shyam Prabhakaran
• 金额: $ 27.47万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8895098
• 关键词: Academic Medical Centers; Acute; Adult; Aging; Agreement; Area; Biological Markers; Blood Vessels; Brain hemorrhage; Caring; Cause of Death; Cessation of life; Chicago; Child; Clinical; Clinical Trials; Collaborations; Conduct Clinical Trials; County; Data; Development; Disease; Elderly; Emergency Medicine; Emergency treatment; Enrollment; Ensure; Environment; Faculty; Fellowship; Fostering; Funding; Future; Growth and Development function; Health; Hospitals; Individual; Industry; Institutes; Institutional Review Boards; International; Ischemic Stroke; Leadership; Medical Research; Mentors; Mentorship; Neurological emergencies; Neurology; Neurorehabilitation; Neurosciences; Outcome; Outcomes Research; Patient Recruitments; Patients; Pediatric Hospitals; Pediatric Neurology; Phase; Phase III Clinical Trials; Plasminogen Activator; Population; Prevention trial; Procedures; Process; Qualifying; Recording of previous events; Recruitment Activity; Registries; Rehabilitation therapy; Research; Research Infrastructure; Research Methodology; Research Personnel; Resources; Role; Sample Size; Science; Seminal; Site; Societies; Stroke; System; Testing; Training Programs; Translations; United States; United States National Institutes of Health; Universities; Work; acute stroke; arm; base; career; cooking; cost; data management; disability; effective therapy; improved; medical schools; metropolitan; nervous system disorder; neurosurgery; patient population; response; stroke rehabilitation; treatment trial

DESCRIPTION (provided by applicant): There is a great need for effective treatments in stroke as the disease is a leading cause of death and disability in the United States. Despite scientific and technological advances, there has been limited translation into clinical outcome benefits for stroke patients. As several recent trials illustrate, a key factor in developing breakthrough stroke treatments is the rapid execution of clinical trials with sufficient sample sizes, robust enrollment, timely completion, and rigorous and uniform infrastructure across sites. This application is in response to the recent NINDS request for Regional Coordinating Stroke Centers (RCC) in the NINDS Stroke Trials Network (RFA-NS-13-011). The Chicago Stroke Trials Consortium (CSTC) led by the RCC at Northwestern University (NU) is a collaborative network of 7 centers in the Chicago metropolitan area: Northwestern Memorial Hospital (NMH), Lurie Children's Hospital (LCH), Rehabilitation Institute of Chicago (RIC) [all part of NU's McGaw Medical Center], the University of Chicago (UC), Rush University Medical Center (RUMC), Loyola University Chicago (LUMC), and the Hektoen Institute for Medical Research/John H. Stroger, Jr. Hospital of Cook County (CCH). We have enlisted institutional support including agreements to utilize a federated institutional review board process (central IRB) and master trial agreements to ensure rapid implementation of future trials from each of our participating sites. The RCC aims to combine resources, diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients spanning from children to elderly and from acute treatment to rehabilitation. The CSTC will participate in acute stroke, rehabilitation, and prevention trials, and has expertise from investigators in vascular neurology, neurosurgery, neurocritical care, neuroradiology, interventional neuroradiology, neurorehabilitation, pediatric neurology, and emergency medicine. The amassed investigators have backgrounds in all aspects of stroke research and leadership roles in many recently completed and ongoing NIH and industry-sponsored trials. The consortium has a combined geographic referral base encompassing almost 10 million people and has a history of collaboration in clinical and scientific endeavors. Drawing from the vast geographic reach of our hospitals and their resources and investigators, the CSTC is uniquely qualified to deliver a diverse stroke patient population, provide consolidated multi-disciplinary and multi-institutional expertise and leadership for network trials, and ensure mentoring for trainees and junior faculty seeking academic careers in stroke.

描述（由申请人提供）：由于中风是美国死亡和残疾的主要原因，因此非常需要有效的治疗方法。尽管科学和技术取得了进步，但对中风患者的临床结局益处的转化有限。正如最近的几项试验所表明的那样，开发突破性中风治疗方法的关键因素是快速执行临床试验，具有足够的样本量，强大的招募，及时完成以及严格和统一的基础设施。 本申请是对NINDS卒中试验网络（RFA-NS-13-011）中的区域协调卒中中心（RCC）的最新NINDS请求的回应。由西北大学（NU）RCC领导的芝加哥卒中试验联盟（CSTC）是一个由芝加哥大都市区的7个中心组成的协作网络：西北纪念医院（NMH），Lurie儿童医院（LCH），芝加哥康复研究所（RIC）[所有NU McGaw医学中心的一部分]，芝加哥大学（UC），拉什大学医学中心（RUMC），洛约拉大学芝加哥（LUMC）和Hektoen医学研究所/John H.小斯特罗格库克县医院（CCH）我们已获得机构支持，包括使用联合机构审查委员会流程（中心IRB）的协议和主试验协议，以确保我们每个参与研究中心的未来试验快速实施。RCC的目标是结合联合收割机资源，多样化的教师与中风的专业知识，并获得从儿童到老年人和从急性治疗到康复中风患者的多民族人口。CSTC将参与急性卒中、康复和预防试验，并拥有血管神经病学、神经外科、神经重症监护、神经放射学、介入神经放射学、神经康复、儿科神经病学和急诊医学研究者的专业知识。这些研究人员具有中风研究各个方面的背景，并在许多最近完成和正在进行的NIH和行业赞助的试验中担任领导角色。该联盟拥有一个涵盖近1000万人的综合地理转诊基础，并在临床和科学工作方面有着合作的历史。从我们的医院及其资源和研究人员的广阔地理范围，CSTC是唯一有资格提供多样化的中风患者人群，提供综合的多学科和多机构的专业知识和领导网络试验，并确保指导学员和初级教师寻求中风学术生涯。